Margetuximab (anti-HER2), erb-b2 受体酪氨酸激酶 2 抗体

CAS: 1350624-75-7 货号: Ab170524
有货
级别和纯度: 无动物源 ? 无动物源(Animal Free)—— 不含动物源成分生产,降低污染风险。适用于避免动物源材料的生物制造和培养。 无载体 ? 无载体(Carrier Free)—— 不含添加的载体蛋白/稳定剂。当载体(如 BSA)会干扰偶联或敏感检测时使用。 重组 ? 重组(Recombinant)—— 通过重组表达生产,序列确定、批次稳定。适用于来源明确、无动物源的可重现蛋白。 ExactAb™ ? ExactAb™ —— 阿拉丁强调精准和验证质量的抗体系列。适用于可靠、特异性经验证的抗体应用。 低内毒素 ? 低内毒素级 —— 内毒素降至受控低水平。适用于高内毒素会造成干扰的敏感生物工作。 无叠氮钠 ? 无叠氮(Azide Free)—— 不含叠氮化钠防腐剂。适用于叠氮有毒或有抑制作用的偶联、细胞工作或检测。 已验证 ? 已验证级 —— 发布前在特定应用中确认性能。当需要试剂按声称工作的书面保证时使用。 ≥95%(SDS-PAGE&SEC-HPLC) 见COA
应用
Animal Model, ELISA, Flow Cytometry, Functional Assay
宿主种属
人(Human)
种属反应性
人(Human), 小鼠(Mouse)
亚型
Human IgG1
偶联
Unconjugated
★
规格
库存
价格
数量
100μg
Ab170524-100μg
现货 Stock Image
¥764.90
1mg
Ab170524-1mg
现货 Stock Image
¥3,824.90
5mg
Ab170524-5mg
现货 Stock Image
¥7,649.90
10mg
Ab170524-10mg
期货 Stock Image
¥18,999.90
请输入您要添加的产品数量

概述

Margetuximab是一种嵌合抗 HER2 单克隆抗体,具有优化的 Fc 结构域,EC50 为 39.33 ng/mL。Margetuximab 可用于转移性 HER2 阳性乳腺癌研究。

Margetuximab is a chimeric anti-HER2 monoclonal antibody optimized Fc domain, with an EC50 value of 39.33 ng/mL. Margetuximab can be used for researching metastatic HER2-positive breast cancer.
Purity
>95% (SDS-PAGE&SEC)
Endotoxin Level
< 1.0 EU/mg

规格

产品名称
Margetuximab (anti-HER2), erb-b2 受体酪氨酸激酶 2 抗体
别名
玛格妥昔单抗|Margetuximab(抗 HER2)
英文别名
Verb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog antibody|C erb B2/neu protein antibody|CD340 antibody|CD340 antigen antibody|Cerb B2/neu protein antibody|CerbB2 antibody|Erb b2 receptor tyrosine kinase 2 antibody|ErbB-2 proto-oncogene antibody|ERBB2 antibody|HER 2 antibody|HER 2/NEU antibody|HER2 antibody|Herstatin antibody|Human epidermal growth factor receptor 2 antibody|Metastatic lymph node gene 19 protein antibody|MLN 19 antibody|MLN19 antibody|NEU antibody|NEU proto oncogene antibody|Neuro/glioblastoma derived oncogene homolog antibody|Neuroblastoma/glioblastoma derived oncogene homolog antibody|NGL antibody|p185erbB2 antibody|Proto-oncogene c-ErbB-2 antibody|Proto-oncogene Neu antibody|Receptor tyrosine-protein kinase erbB-2 antibody|TKR1 antibody|Tyrosine kinase type cell surface receptor HER2 antibody|Tyrosine kinase-type cell surface receptor HER2 antibody|V erb b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog) antibody|V erb b2 avian erythroblastic leukemia viral oncogene homolog 2 antibody|V erb b2 avian erythroblastic leukemia viral oncoprotein 2 antibody|V erb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) antibody|V erb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog antibody|Verb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) antibody|CD340 antigen|CD340|c-erb B2/neu protein|EGFR2|ErbB2|HER2|HER-2|HER2EC 2.7.10.1|herstatin|Metastatic lymph node gene 19 protein|MLN 19|MLN19|Neu Oncogene|NEUHER-2/neu|neuroblastoma/glioblastoma derived oncogene homolog|NGL|NGLTKR1|p185erbB2|Proto-oncogene c-ErbB-2|Proto-oncogene Neu|TKR1|Tyrosine kinase-type cell surface receptor HER2|v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2(neuro/glioblastoma derived oncogene homolog)|v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastomaderived oncogene homolog (avian)
规格或纯度
无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
宿主种属
人(Human)
特异性
ErbB2
应用
ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR)
种属反应性
人(Human),小鼠(Mouse)
偶联
Unconjugated
作用类型
抑制剂
作用机制
erb-b2 受体酪氨酸激酶 2 抗体
抗体类型
Primary antibody
克隆类型
重组抗体
Format
Whole IgG
亚型
Human IgG1
轻链亚型
kappa
纯化方法
Protein A purified
纯度
>95%
来源
CHO supernatant
浓度
见COA
CAS编号和信息
1350624-75-7
分子类型
抗体
产品线
生物产品
储存与运输
物理外观
Liquid
储存缓冲液
Supplied as a 0.22 μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂
No
储存条件
-80℃储存,避免反复冻融
运输条件
特低温运输
稳定性与储存
在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
图片

Margetuximab (anti-HER2) (Ab170524) - Flow Cytometry
Flow Cytometry analysis of MCF-7 cells labelling HER2 (red) with Margetuximab (anti-HER2) (Ab170524). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Margetuximab (anti-HER2) (Ab170524) - SEC
The purity of Margetuximab (anti-HER2) (Ab170524) is more than 95% verified by HPLC.

高级数据

关联靶点(人)
ERBB2 Tclin 受体酪氨酸蛋白激酶 erbB-2(Receptor tyrosine-protein kinase erbB-2) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
ERBB2 Tclin Receptor protein-tyrosine kinase erbB-2 (7851 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ERBB2 Tclin Epidermal growth factor receptor and ErbB2 (HER1 and HER2) (186 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ERBB2 Tclin Epidermal growth factor receptor (487 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
ERBB2 Tclin FASN/HER2 (2 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
作用机制
作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献
质检证书(CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:

通过匹配包装上的批号来查找并下载产品的 COA,每批产品都进行了严格的验证,您可放心使用!

找到4个结果

批号(Lot Number) 证书类型 货号
ZJ24F0911488ZJ24F0911488 分析证书 Ab170524
ZJ24F0911489ZJ24F0911489 分析证书 Ab170524
ZJ23F1001271ZJ23F1001271 分析证书 Ab170524
ZJ23F1001272ZJ23F1001272 分析证书 Ab170524
溶液计算器

相关产品

Pertuzumab (anti-HER2)-19552,用于ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR)各种应用,>95%,erb-b2 受体酪氨酸激酶 2 抗体
Trastuzumab (anti-HER2)-19552,>95%,erb-b2 受体酪氨酸激酶 2 抗体
Goat Anti-Human IgG H&L (HRP)-19553,用于WB,ELISA,IHC各种应用
Mouse Anti-Human IgG Antibody-19553,用于ELISA,CLIA各种应用
Mouse Anti-Human IgG H&L (HRP)-19553,用于ELISA各种应用
Mouse Anti-Human IgM Antibody-19553,用于ELISA各种应用
Human IgG-19554,>95%
Goat Anti-Human IgG Antibody-19553,用于ELISA,CLIA,LFAs,WB and other immunoassay methods各种应用,≥ 95%
Mouse Anti-Human IgA H&L Antibody-19553
Goat Anti-Human IgG (HRP)-19553
Goat Anti-Human IgG (Biotin)-19553
Goat Anti-Human IgG (APC)-19553
Goat Anti-Human IgG (Cy5)-19553
Goat Anti-Human IgG (TRITC)-19553
Goat Anti-Human IgG (PE)-19553
Goat Anti-Human IgG (FITC)-19553
Mouse Anti-Human IgE epsilon chain Antibody-19553
Goat Anti-Human IgG Fc Antibody-19553
Gancotamab (anti-HER2)-19552,受体蛋白-酪氨酸激酶 erbB-2 结合剂的结合剂
Human IgG2-Kappa-19554
Human IgG3-kappa-19554
Human IgG1-kappa, anti-Spike RBD-19554
Human IgG4-kappa-19554
Goat Anti-Human IgG (AF647)-19553
Goat Anti-Human IgG (AF405)-19553
Human IgG (FITC)-19554
Human IgG (APC)-19554
Human IgG1(P331S/E430G)-kappa, anti-HEL-19554
Human IgG (PE)-19554
Human IgG1(D265A/N297A)-kappa, anti-HEL-19554
Human IgG1(K409R/E356D/M358L)-kappa, anti-HEL-19554
Human IgG1(P329G/E356D/M358L)-kappa, anti-HEL-19554
Human IgG1(F405L)-kappa, anti-HEL-19554
Human IgG1(N297Q)-kappa, anti-HEL-19554
Human IgG (Biotin)-19554
Human IgG1(N297S)-kappa, anti-HEL-19554
Human IgG1(E233A/L235A)-kappa, anti-HEL-19554
Human IgG1(K214R/N297A)-kappa, anti-HEL-19554
Human IgG1(K214R/L234A/L235A)-kappa, anti-HEL-19554
Human IgG1(N297A/E356D/M358L)-kappa, anti-HEL-19554
Human IgG1(L234F/L235E)-kappa, anti-HEL-19554
Human IgG1(D265A)-kappa, anti-HEL-19554
Human IgG1(K214R/L234F/L235E/P331S)-kappa, anti-HEL-19554
Human IgG1(K214R/E356D/M358L)-kappa, anti-HEL-19554
Human IgG1(L234A/L235A/G237A)-kappa, anti-HEL-19554
Human IgG1(L234A/L235A/F405L)-kappa, anti-HEL-19554
Human IgG1(D270N)-kappa, anti-HEL-19554
Human IgG4(S228P)-kappa, anti-HEL-19554
Human IgG1(N297A)-kappa, anti-HEL-19554
Human IgG4(S228P/L235E/P329G)-kappa, anti-HEL-19554
Human IgG1-lambda1, anti-Spike RBD-19554
Human IgG1-lambda2, anti-Spike RBD-19554
Disitamab (anti-ERBB2)-19552
Timigutuzumab (anti-ERBB2)-19552
Goat Anti-Human IgG (AF555)-19553
Coprelotamab (anti-ERBB2)-19552
Human IgG1-kappa (AF647), anti-Spike RBD-19554
Human IgG1-kappa (AF405), anti-Spike RBD-19554
Human IgG1-kappa (APC), anti-Spike RBD-19554
Human IgG1-kappa (Biotin), anti-Spike RBD-19554
Human IgG1-kappa (AF700), anti-Spike RBD-19554
Human IgG1-kappa (FITC), anti-Spike RBD-19554
Human IgG1-kappa (AF555), anti-Spike RBD-19554
Centrose patent anti-dysadherin (anti-Dysadherin)-19552
Human IgG (AF647)-19554
Human IgG (AF488)-19554
Human IgG (AF700)-19554
Human IgG (AF405)-19554
Goat Anti-Human IgG (AF488)-19553
Goat Anti-Human IgG Fc (Cy5)-19553
Goat Anti-Human IgG Fc (AF555)-19553
Goat Anti-Human IgG Fc (TRITC)-19553
Goat Anti-Human IgG Fc (AF700)-19553
Goat Anti-Human IgG Fc (AF405)-19553
Goat Anti-Human IgG Fc (Biotin)-19553
Goat Anti-Human IgG Fc (AF647)-19553
Goat Anti-Human IgG Fc (FITC)-19553
Human IgG (AF555)-19554