产品名称	Ozanezumab (anti-RTN4), 网状结构 4 的抗体
英文别名	Foocen \| Neurite outgrowth inhibitor \| Neuroendocrine-specific protein \| Neuroendocrine-specific protein C homolog \| Nogo protein \| NSP \| Reticulon-5 \| RTN-x
规格或纯度	无载体, 重组, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
生化机理	Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Isoform 2 reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration. Isoform 2 and isoform 3 inhibit BACE1 activity and amyloid precursor protein processing.
宿主种属	人(Human)
特异性	RTN4
应用	ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR)
种属反应性	人(Human)
作用类型	抑制剂
作用机制	网状结构 4 的抗体

AI解读

产品属性

抗体类型	Primary antibody
Format	Whole IgG
亚型	Human IgG1
轻链亚型	kappa
SDS-PAGE	150 kDa
纯化方法	Protein A purified
纯度	>95%
来源	CHO supernatant
物理外观	Liquid
储存缓冲液	Supplied as a 0.22μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂	No
浓度	见COA
储存温度	-80℃储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
CAS编号和信息	1310680-64-8
分子类型	抗体

图片

ELISA: Ozanezumab (anti-RTN4) (Ab170567)

Ozanezumab (anti-RTN4) (Ab170567) - ELISA
Immobilized Recombinant Human NOGO-A(586-785)/RTN4-His protein at 2.0 μg/mL can bind Ozanezumab (anti-RTN4) (Ab170567) with the EC50 of 13.32 ng/mL.

SEC: Ozanezumab (anti-RTN4) (Ab170567)

Ozanezumab (anti-RTN4) (Ab170567) - SEC
The purity of Ozanezumab (anti-RTN4) (Ab170567) is more than 95% verified by HPLC.

关联靶点（人）

RTN4 Tbio 网状结构-4(Reticulon-4) (0 活性数据)

点击查看靶蛋白信息： RTN4

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

技术规格说明书

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

输入批号以搜索分析图谱:

通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

找到3个结果

批号(Lot Number)	证书类型	日期	货号
ZJ25F0116619	分析证书	25-01-07	Ab170567
ZJ25F0116618	分析证书	25-01-07	Ab170567
ZJ25F0116617	分析证书	25-01-07	Ab170567

可替换产品

参考文献

1. Chen MS, Huber AB, van der Haar ME, Frank M, Schnell L, Spillmann AA, Christ F, Schwab ME. (2000) Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1.. Nature, 403 (6768): (434-9). [PMID:10667796] [10.1021/op500134e]
2. Jokic N, Gonzalez de Aguilar JL, Dimou L, Lin S, Fergani A, Ruegg MA, Schwab ME, Dupuis L, Loeffler JP. (2006) The neurite outgrowth inhibitor Nogo-A promotes denervation in an amyotrophic lateral sclerosis model.. EMBO Rep, 7 (11): (1162-7). [PMID:17039253] [10.1021/op500134e]
3. Schmidt ER, Pasterkamp RJ, van den Berg LH. (2009) Axon guidance proteins: novel therapeutic targets for ALS?. Prog Neurobiol, 88 (4): (286-301). [PMID:19523502] [10.1021/op500134e]
4. Schnell L, Schwab ME. (1990) Axonal regeneration in the rat spinal cord produced by an antibody against myelin-associated neurite growth inhibitors.. Nature, 343 (6255): (269-72). [PMID:2300171] [10.1021/op500134e]
5. Caroni P, Schwab ME. (1988) Antibody against myelin-associated inhibitor of neurite growth neutralizes nonpermissive substrate properties of CNS white matter.. Neuron, 1 (1): (85-96). [PMID:3272156] [10.1021/op500134e]
6. Yang J, Yu L, Bi AD, Zhao SY. (2000) Assignment of the human reticulon 4 gene (RTN4) to chromosome 2p14-->2p13 by radiation hybrid mapping.. Cytogenet Cell Genet, 88 (1-2): (101-2). [PMID:10773680] [10.1021/op500134e]
7. GrandPré T, Nakamura F, Vartanian T, Strittmatter SM. (2000) Identification of the Nogo inhibitor of axon regeneration as a Reticulon protein.. Nature, 403 (6768): (439-44). [PMID:10667797] [10.1021/op500134e]
8. Crane EA, Heydenreuter W, Beck KR, Strajhar P, Vomacka J, Smiesko M, Mons E, Barth L, Neuburger M, Vedani A, Odermatt A, Sieber SA, Gademann K.. (2019) Profiling withanolide A for therapeutic targets in neurodegenerative diseases.. Bioorg Med Chem, 27 (12): (2508-2520). [PMID:30929949] [10.1016/j.bmc.2019.03.022]
9. Nagase, T T and 9 more authors.. (1998) Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.. DNA research : an international journal for rapid publication of reports on genes and genomes, (31): [PMID:10048485]
10. Prinjha, R R and 8 more authors.. (2000) Inhibitor of neurite outgrowth in humans.. Nature, (27): [PMID:10667780]
11. Zhang, Q H QH and 20 more authors.. (2000) Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.. Genome research, [PMID:11042152]
12. Tagami, S S, Eguchi, Y Y, Kinoshita, M M, Takeda, M M and Tsujimoto, Y Y.. (2000) A novel protein, RTN-XS, interacts with both Bcl-XL and Bcl-2 on endoplasmic reticulum and reduces their anti-apoptotic activity.. Oncogene, (23): [PMID:11126360]
13. Fournier, A E AE, GrandPre, T T and Strittmatter, S M SM.. (2001) Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration.. Nature, (18): [PMID:11201742]
14. Zhou, Z M ZM and 9 more authors.. (2002) Expression of a novel reticulon-like gene in human testis.. Reproduction (Cambridge, England), [PMID:11866689]
15. Ng, Cherry Ee Lin CE and Tang, Bor Luen BL.. (2002) Nogos and the Nogo-66 receptor: factors inhibiting CNS neuron regeneration.. Journal of neuroscience research, (1): [PMID:11891768]
16. Oertle, Thomas T, Huber, Chantal C, van der Putten, Herman H and Schwab, Martin E ME.. (2003) Genomic structure and functional characterisation of the promoters of human and mouse nogo/rtn4.. Journal of molecular biology, (10): [PMID:12488097]
17. Qi, Bing B and 8 more authors.. (2003) Pro-apoptotic ASY/Nogo-B protein associates with ASYIP.. Journal of cellular physiology, [PMID:12811824]
18. Acevedo, Lisette L and 8 more authors.. (2004) A new role for Nogo as a regulator of vascular remodeling.. Nature medicine, [PMID:15034570]
19. He, Wanxia W and 5 more authors.. (2004) Reticulon family members modulate BACE1 activity and amyloid-beta peptide generation.. Nature medicine, [PMID:15286784]
20. Wan, Dafang D and 24 more authors.. (2004) Large-scale cDNA transfection screening for genes related to cancer development and progression.. Proceedings of the National Academy of Sciences of the United States of America, (2): [PMID:15498874]
21. Miao, Robert Qing RQ and 8 more authors.. (2006) Identification of a receptor necessary for Nogo-B stimulated chemotaxis and morphogenesis of endothelial cells.. Proceedings of the National Academy of Sciences of the United States of America, (18): [PMID:16835300]
22. Murayama, Kiyoko S KS and 5 more authors.. (2006) Reticulons RTN3 and RTN4-B/C interact with BACE1 and inhibit its ability to produce amyloid beta-protein.. The European journal of neuroscience, [PMID:16965550]
23. He, Wanxia W and 6 more authors.. (2006) Mapping of interaction domains mediating binding between BACE1 and RTN/Nogo proteins.. Journal of molecular biology, (27): [PMID:16979658]
24. Budel, Stéphane S and 18 more authors.. (2008) Genetic variants of Nogo-66 receptor with possible association to schizophrenia block myelin inhibition of axon growth.. The Journal of neuroscience : the official journal of the Society for Neuroscience, (3): [PMID:19052207]
25. Hu, Junjie J and 7 more authors.. (2009) A class of dynamin-like GTPases involved in the generation of the tubular ER network.. Cell, (7): [PMID:19665976]
26. Di Lorenzo, Annarita A, Manes, Thomas D TD, Davalos, Alberto A, Wright, Paulette L PL and Sessa, William C WC.. (2011) Endothelial reticulon-4B (Nogo-B) regulates ICAM-1-mediated leukocyte transmigration and acute inflammation.. Blood, (17): [PMID:21183689]
27. Yamamoto, Yasunori Y, Yoshida, Asuka A, Miyazaki, Naoyuki N, Iwasaki, Kenji K and Sakisaka, Toshiaki T.. (2014) Arl6IP1 has the ability to shape the mammalian ER membrane in a reticulon-like fashion.. The Biochemical journal, (15): [PMID:24262037]
28. Urade, Takeshi T, Yamamoto, Yasunori Y, Zhang, Xia X, Ku, Yonson Y and Sakisaka, Toshiaki T.. (2014) Identification and characterization of TMEM33 as a reticulon-binding protein.. The Kobe journal of medical sciences, (6): [PMID:25612671]
29. Christodoulou, Andri A, Santarella-Mellwig, Rachel R, Santama, Niovi N and Mattaj, Iain W IW.. (2016) Transmembrane protein TMEM170A is a newly discovered regulator of ER and nuclear envelope morphogenesis in human cells.. Journal of cell science, (15): [PMID:26906412]
30. Wang, Songyu S, Tukachinsky, Hanna H, Romano, Fabian B FB and Rapoport, Tom A TA.. (2016) Cooperation of the ER-shaping proteins atlastin, lunapark, and reticulons to generate a tubular membrane network.. eLife, (13): [PMID:27619977]
31. Rämö, Olli O and 10 more authors.. (2016) NOGO-A/RTN4A and NOGO-B/RTN4B are simultaneously expressed in epithelial, fibroblast and neuronal cells and maintain ER morphology.. Scientific reports, (27): [PMID:27786289]
32. Lee, Shin-Haw and 18 more authors.. (2020) REEP5 depletion causes sarco-endoplasmic reticulum vacuolization and cardiac functional defects.. Nature communications, (19): [PMID:32075961]

溶液计算器

摩尔浓度计算器

计算溶液所需的质量、体积或浓度。

质量

浓度

体积

分子量

g/mol

稀释计算器

计算配制储备溶液所需的稀释度。

浓度1（C1）

体积 1 (V1)

浓度 2 (C2)

体积 2 (V2)

复溶计算器

复溶计算器允许您快速计算试剂的体积，以复溶小瓶。只需输入试剂的质量和目标浓度，计算器将确定其余部分。

体积（添加到小瓶中）

质量（小瓶）

所需的复溶浓度

Ozanezumab (anti-RTN4), 网状结构 4 的抗体

库存信息

库存信息

库存信息

库存信息

基本信息

AI解读

产品属性

图片

关联靶点（人）

作用机制

技术规格说明书

质检证书（CoA,COO,BSE/TSE 和分析图谱)

相关文档

相关产品

可替换产品

参考文献

溶液计算器

摩尔浓度计算器

稀释计算器

复溶计算器