货号 (SKU)

包装规格

是否现货

价格

数量

Ab175463-100μg

100μg

现货

Ab175463-1mg

1mg

现货

Ab175463-5mg

5mg

现货

Ab175463-10mg

10mg

期货

基本信息

产品名称	Basiliximab (anti-IL-2Ra), 白细胞介素-2 受体亚基 α 抗体
别名	巴利昔单抗 \| 巴利昔单抗(抗 IL-2Ra)
英文别名	Interleukin 2 receptor alpha chain antibody \| CD25 antibody \| CD25 antigen antibody \| IDDM10 antibody \| IL 2 receptor alpha subunit antibody \| IL-2 receptor subunit alpha antibody \| IL-2-RA antibody \| IL-2R subunit alpha antibody \| IL2 RA antibody \| IL2 R
规格或纯度	无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
宿主种属	人(Human)
特异性	IL2RA
种属反应性	人(Human),恒河猴(Rhesus monkey)
偶联	Unconjugated
作用类型	抑制剂
作用机制	白细胞介素-2 受体亚基 α 抗体

AI解读

产品属性

克隆类型	重组抗体
Format	Whole IgG
亚型	Human IgG1
轻链亚型	kappa
SDS-PAGE	27.3 kDa (Light Chain) & 50.8 kDa (Heavy Chain), under reducing conditions; 178.1 kDa, under non-reducing conditions.
纯化方法	Protein A purified
纯度	>95%
物理外观	Liquid
储存缓冲液	Supplied as a 0.22μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂	No
浓度	见COA
储存温度	-80℃储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
CAS编号和信息	179045-86-4
分子类型	抗体

图片

ELISA: Basiliximab (anti-IL-2Ra) (Ab175463)

Basiliximab (anti-IL-2Ra) (Ab175463) - ELISA
Immobilized Human IL-2Ra/CD25-his at 2.0 μg/mL can bind Basiliximab (anti-IL-2Ra) (Ab175463) with the EC₅₀ of 2.65 ng/mL.

SEC: Basiliximab (anti-IL-2Ra) (Ab175463)

Basiliximab (anti-IL-2Ra) (Ab175463) - SEC
The purity of Basiliximab (anti-IL-2Ra) (Ab175463) is more than 95% verified by HPLC.

关联靶点（人）

IL2RA Tclin 白细胞介素-2 受体亚基 α(Interleukin-2 receptor subunit alpha) (0 活性数据)

点击查看靶蛋白信息： IL2RA

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

IL2RA Tclin Interleukin-2 receptor alpha chain (2 活性数据)

点击查看靶蛋白信息： IL2RA

活性类型	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

技术规格说明书

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C of A & Other Certificates(BSE/TSE, COO):

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找到3个结果

批号(Lot Number)	证书类型	日期	货号
ZJ24F0303747	分析证书	24-03-29	Ab175463
ZJ24F0303746	分析证书	24-03-29	Ab175463
ZJ24F0303745	分析证书	24-03-29	Ab175463

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参考文献

1. Kiyokawa, T T and 8 more authors.. (1989) Cytotoxicity of interleukin 2-toxin toward lymphocytes from patients with adult T-cell leukemia.. Cancer research, (15): [PMID:2786749]
2. Leonard, W J WJ and 7 more authors.. (1985) Structure of the human interleukin-2 receptor gene.. Science (New York, N.Y.), (8): [PMID:2996141]
3. Ishida, N N and 7 more authors.. (1985) Molecular cloning and structure of the human interleukin 2 receptor gene.. Nucleic acids research, (11): [PMID:2999698]
4. Cross, S L SL and 5 more authors.. (1987) Regulation of the human interleukin-2 receptor alpha chain promoter: activation of a nonfunctional promoter by the transactivator gene of HTLV-I.. Cell, (10): [PMID:3030566]
5. Miedel, M C MC, Hulmes, J D JD, Weber, D V DV, Bailon, P P and Pan, Y C YC.. (1988) Structural analysis of recombinant soluble human interleukin-2 receptor. Primary structure, assignment of disulfide bonds and core IL-2 binding structure.. Biochemical and biophysical research communications, (15): [PMID:3134887]
6. Leonard, W J WJ and 9 more authors.. (1984) Molecular cloning and expression of cDNAs for the human interleukin-2 receptor.. Nature, [PMID:6090948]
7. Nikaido, T T and 8 more authors.. (1984) Molecular cloning of cDNA encoding human interleukin-2 receptor.. Nature, [PMID:6090949]
8. Bamborough, P P, Hedgecock, C J CJ and Richards, W G WG.. (1994) The interleukin-2 and interleukin-4 receptors studied by molecular modelling.. Structure (London, England : 1993), (15): [PMID:7529123]
9. Krouwels, F H FH and 5 more authors.. (1996) Glucocorticosteroids affect functions of airway- and blood-derived human T-cell clones, favoring the Th1 profile through two mechanisms.. American journal of respiratory cell and molecular biology, [PMID:8600944]
10. Berard, J L JL, Velez, R L RL, Freeman, R B RB and Tsunoda, S M SM.. (1999) A review of interleukin-2 receptor antagonists in solid organ transplantation.. Pharmacotherapy, [PMID:10512062]
11. Deloukas, P P and 135 more authors.. (2004) The DNA sequence and comparative analysis of human chromosome 10.. Nature, (27): [PMID:15164054]
12. Wang, Xinquan X, Rickert, Mathias M and Garcia, K Christopher KC.. (2005) Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors.. Science (New York, N.Y.), (18): [PMID:16293754]
13. Garcia, C D CD and 5 more authors.. Plasmapheresis for recurrent posttransplant focal segmental glomerulosclerosis.. Transplantation proceedings, [PMID:16908318]
14. and Turturro, Francesco F.. (2007) Denileukin diftitox: a biotherapeutic paradigm shift in the treatment of lymphoid-derived disorders.. Expert review of anticancer therapy, [PMID:17187516]
15. and Waldmann, Thomas A.. (2007) Anti-Tac (daclizumab, Zenapax) in the treatment of leukemia, autoimmune diseases, and in the prevention of allograft rejection: a 25-year personal odyssey.. Journal of clinical immunology, [PMID:17216565]
16. and Waldmann, T A TA.. (2007) Daclizumab (anti-Tac, Zenapax) in the treatment of leukemia/lymphoma.. Oncogene, (28): [PMID:17530023]
17. Lowe, Christopher E CE and 12 more authors.. (2007) Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes.. Nature genetics, [PMID:17676041]
18. Duvic, Madeleine M and Talpur, Rakhshandra R.. (2008) Optimizing denileukin diftitox (Ontak) therapy.. Future oncology (London, England), [PMID:18684057]
19. Goudy, Kevin K and 18 more authors.. (2013) Human IL2RA null mutation mediates immunodeficiency with lymphoproliferation and autoimmunity.. Clinical immunology (Orlando, Fla.), [PMID:23416241]
20. Bezrodnik, L L, Caldirola, M S MS, Seminario, A G AG, Moreira, I I and Gaillard, M I MI.. (2014) Follicular bronchiolitis as phenotype associated with CD25 deficiency.. Clinical and experimental immunology, [PMID:24116927]
21. Chen, X X, Ji, Z L ZL and Chen, Y Z YZ.. (2002) TTD: Therapeutic Target Database.. Nucleic acids research, (1): [PMID:11752352]

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Basiliximab (anti-IL-2Ra), 白细胞介素-2 受体亚基 α 抗体

库存信息

库存信息

库存信息

库存信息

基本信息

AI解读

产品属性

图片

关联靶点（人）

作用机制

技术规格说明书

质检证书（CoA,COO,BSE/TSE 和分析图谱)

相关文档

可替换产品

参考文献

溶液计算器

摩尔浓度计算器

稀释计算器

复溶计算器

Basiliximab (anti-IL-2Ra), 白细胞介素-2 受体亚基 α 抗体

库存信息

库存信息

库存信息

库存信息

基本信息

AI解读

产品属性

图片

关联靶点（人）

作用机制

技术规格说明书

质检证书（CoA,COO,BSE/TSE 和分析图谱)

相关文档

相关产品

可替换产品

参考文献

溶液计算器

摩尔浓度计算器

稀释计算器

复溶计算器