货号 (SKU)

包装规格

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价格

数量

Ab175478-100μg

100μg

现货

Ab175478-1mg

1mg

现货

Ab175478-5mg

5mg

现货

Ab175478-10mg

10mg

期货

基本信息

产品名称	Brazikumab (anti-IL-23), 白细胞介素 23 抑制剂
别名	布雷库单抗 \| 巴西库单抗(抗 IL-23)
英文别名	IL 23 A antibody \| IL 23 antibody \| IL 23 subunit alpha antibody \| IL 23A antibody \| IL 23p19 antibody \| IL-23 subunit alpha antibody \| IL-23-A antibody \| IL-23p19 antibody \| IL12B antibody \| IL23 antibody \| Il23a antibody \| IL23A_HUMAN antibody \| IL23P19
规格或纯度	无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
宿主种属	人(Human)
特异性	IL23A
种属反应性	人(Human)
偶联	Unconjugated
作用类型	抑制剂
作用机制	白细胞介素 23 抑制剂

产品属性

克隆类型	重组抗体
Format	Whole IgG
亚型	Human IgG2
轻链亚型	lambda
SDS-PAGE	29.2 kDa (Light Chain) & 52.3 kDa (Heavy Chain), under reducing conditions; 175.4 kDa, under non-reducing conditions.
纯化方法	Protein A purified
纯度	>95%
物理外观	Liquid
储存缓冲液	Supplied as a 0.22μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂	No
浓度	见COA
储存温度	-80℃储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
CAS编号和信息	1610353-18-8
分子类型	抗体

图片

SEC: Brazikumab (anti-IL-23) (Ab175478)

Brazikumab (anti-IL-23) (Ab175478) - SEC
The purity of Brazikumab (anti-IL-23) (Ab175478) is more than 95% verified by HPLC.

关联靶点（人）

IL23A Tclin 白细胞介素-23 亚基 α(Interleukin-23 subunit alpha) (0 活性数据)

点击查看靶蛋白信息： IL23A

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

安全和危险性（GHS）

SDS英文版

技术规格说明书

技术规格说明书

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

输入批号以搜索分析图谱:

通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

找到5个结果

批号(Lot Number)	证书类型	日期	货号
ZJ24F1012912	分析证书	24-10-25	Ab175478
ZJ24F1012911	分析证书	24-10-25	Ab175478
ZJ24F1012910	分析证书	24-10-25	Ab175478
ZJ23F1202062	分析证书	23-12-20	Ab175478
ZJ23F1202063	分析证书	23-12-20	Ab175478

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参考文献

1. Cua DJ, Sherlock J, Chen Y, Murphy CA, Joyce B, Seymour B, Lucian L, To W, Kwan S, Churakova T et al.. (2003) Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain.. Nature, 421 (6924): (744-8). [PMID:12610626] [10.1021/op500134e]
2. Ahern PP, Izcue A, Maloy KJ, Powrie F. (2008) The interleukin-23 axis in intestinal inflammation.. Immunol Rev, 226 (13): (147-59). [PMID:19161422] [10.1021/op500134e]
3. Parham C, Chirica M, Timans J, Vaisberg E, Travis M, Cheung J, Pflanz S, Zhang R, Singh KP, Vega F et al.. (2002) A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R.. J Immunol, 168 (11): (5699-708). [PMID:12023369] [10.1021/op500134e]
4. Campa M, Mansouri B, Warren R, Menter A. (2016) A Review of Biologic Therapies Targeting IL-23 and IL-17 for Use in Moderate-to-Severe Plaque Psoriasis.. Dermatol Ther (Heidelb), 6 (1): (1-12). [PMID:26714681] [10.1021/op500134e]
5. Oppmann, B B and 24 more authors.. (2000) Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12.. Immunity, [PMID:11114383]
6. Pirhonen, Jaana J, Matikainen, Sampsa S and Julkunen, Ilkka I.. (2002) Regulation of virus-induced IL-12 and IL-23 expression in human macrophages.. Journal of immunology (Baltimore, Md. : 1950), (15): [PMID:12421946]
7. Smits, Hermelijn H HH and 8 more authors.. (2004) Commensal Gram-negative bacteria prime human dendritic cells for enhanced IL-23 and IL-27 expression and enhanced Th1 development.. European journal of immunology, [PMID:15114670]
8. Schnurr, Max M and 5 more authors.. (2005) Extracellular nucleotide signaling by P2 receptors inhibits IL-12 and enhances IL-23 expression in human dendritic cells: a novel role for the cAMP pathway.. Blood, (15): [PMID:15486065]
9. Fedele, Giorgio G and 5 more authors.. (2005) Bordetella pertussis-infected human monocyte-derived dendritic cells undergo maturation and induce Th1 polarization and interleukin-23 expression.. Infection and immunity, [PMID:15731058]
10. Vanden Eijnden, Serge S, Goriely, Stanislas S, De Wit, Dominique D, Goldman, Michel M and Willems, Fabienne F.. (2006) Preferential production of the IL-12(p40)/IL-23(p19) heterodimer by dendritic cells from human newborns.. European journal of immunology, [PMID:16342235]
11. Piskin, Gamze G, Sylva-Steenland, Regien M R RM, Bos, Jan D JD and Teunissen, Marcel B M MB.. (2006) In vitro and in situ expression of IL-23 by keratinocytes in healthy skin and psoriasis lesions: enhanced expression in psoriatic skin.. Journal of immunology (Baltimore, Md. : 1950), (1): [PMID:16424222]
12. Langowski, John L JL and 9 more authors.. (2006) IL-23 promotes tumour incidence and growth.. Nature, (27): [PMID:16688182]
13. Vaknin-Dembinsky, Adi A, Balashov, Konstantin K and Weiner, Howard L HL.. (2006) IL-23 is increased in dendritic cells in multiple sclerosis and down-regulation of IL-23 by antisense oligos increases dendritic cell IL-10 production.. Journal of immunology (Baltimore, Md. : 1950), (15): [PMID:16751425]
14. Wilson, Nicholas J NJ and 15 more authors.. (2007) Development, cytokine profile and function of human interleukin 17-producing helper T cells.. Nature immunology, [PMID:17676044]
15. Lupardus, Patrick J PJ and Garcia, K Christopher KC.. (2008) The structure of interleukin-23 reveals the molecular basis of p40 subunit sharing with interleukin-12.. Journal of molecular biology, (17): [PMID:18680750]
16. Papp, K K and 12 more authors.. (2015) Tildrakizumab (MK-3222), an anti-interleukin-23p19 monoclonal antibody, improves psoriasis in a phase IIb randomized placebo-controlled trial.. The British journal of dermatology, [PMID:26042589]
17. Bloch, Yehudi and 11 more authors.. (2018) Structural Activation of Pro-inflammatory Human Cytokine IL-23 by Cognate IL-23 Receptor Enables Recruitment of the Shared Receptor IL-12Rβ1.. Immunity, (16): [PMID:29287995]
18. Haugh, Isabel M; Preston, Allie K; Kivelevitch, Dario N and Menter, Alan M.. (2018) Risankizumab: an anti-IL-23 antibody for the treatment of psoriasis.. Drug design, development and therapy, [PMID:30518998]
19. Machado, Álvaro Á and Torres, Tiago T.. (2018) Spotlight on risankizumab and its potential in the treatment of plaque psoriasis: evidence to date.. Psoriasis (Auckland, N.Z.), [PMID:30519540]
20. Sun, Rui and Abraham, Clara.. (2020) IL23 Promotes Antimicrobial Pathways in Human Macrophages, Which Are Reduced With the IBD-Protective IL23R R381Q Variant.. Cellular and molecular gastroenterology and hepatology, [PMID:32474165]
21. Glassman, Caleb R and 10 more authors.. (2021) Structural basis for IL-12 and IL-23 receptor sharing reveals a gateway for shaping actions on T versus NK cells.. Cell, (18): [PMID:33606986]

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Brazikumab (anti-IL-23), 白细胞介素 23 抑制剂

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关联靶点（人）

安全和危险性（GHS）

技术规格说明书

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参考文献

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Brazikumab (anti-IL-23), 白细胞介素 23 抑制剂

库存信息

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库存信息

基本信息

产品属性

图片

关联靶点（人）

安全和危险性（GHS）

技术规格说明书

质检证书（CoA,COO,BSE/TSE 和分析图谱)

相关产品

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参考文献

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