IGN523 (anti-CD98) is a humanized monoclonal antibody targeting CD98. It can be used in patients with relapsed or refractory acute myeloid leukemia (AML).
规格
产品名称
IGN523 (anti-CD98), 4F2hc 抗体
英文别名
Ign523 | solute carrier family 3 (activators of dibasic and neutral amino acidtransport), member 2,4F2 heavy chain antigen | SLC3A2 | NACAE4F2 cell-surface antigen heavy chain | monoclonal 44D7 | MDU1antigen defined by monoclonal 4F2, heavy chain | Lympho
Required for the function of light chain amino-acid transporters. Involved in sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan. Involved in guiding and targeting of LAT1 and LAT2 to the plasma membrane. When associated with SLC7A6 or SLC7A7 acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Required for normal and neoplastic cell growth. When associated with SLC7A5/LAT1, is also involved in the transport of L-DOPA across the blood-brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. When associated with SLC7A5 or SLC7A8, involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Together with ICAM1, regulates the transport activity LAT2 in polarized intestinal cells, by generating and delivering intracellular signals. When associated with SLC7A5, plays an important role in transporting L-leucine from the circulating blood to the retina across the inner blood-retinal barrier.
Post-translational: Phosphorylation on Ser-406; Ser-408 or Ser-410 and on Ser-527 or Ser-531 by ecto-protein kinases favors heterotypic cell-cell interactions.
宿主种属
人(Human)
特异性
SLC3A2
种属反应性
人(Human),食蟹猴(Cynomolgus monkey)
偶联
Unconjugated
作用类型
抗体
作用机制
4F2hc 抗体
克隆类型
重组抗体
Format
Whole IgG
亚型
Human IgG1
轻链亚型
kappa
纯化方法
Protein A purified
浓度
见COA
分子类型
抗体
产品线
生物产品
储存与运输
储存缓冲液
Supplied as a 0.22μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂
No
储存条件
-80℃储存,避免反复冻融
运输条件
特低温运输
稳定性与储存
Store at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle.
图片
IGN523 (anti-CD98) (Ab175559) - Flow Cytometry Flow Cytometry analysis of human peripheral blood lymphocytes labelling CD98 with IGN523 (anti-CD98) (Ab175559) conjugated with biotin (right panel) compared with Human IgG (Biotin) (Ab180314) - Isotype Control (left panel) and detected with SA-PE (rp156150).
IGN523 (anti-CD98) (Ab175559) - Flow Cytometry Flow Cytometry analysis of human peripheral blood lymphocytes labelling CD98 (red) with IGN523 (anti-CD98) (Ab175559) conjugated with biotin and detected with SA-PE (rp156150). Blue - Isotype control, Human IgG (Biotin) (Ab180314). Black - Unlabelled control, cells without incubation with primary antibody.
IGN523 (anti-CD98) (Ab175559) - Flow Cytometry Flow Cytometry analysis of HeLa cells labelling CD98 (red) with IGN523 (anti-CD98) (Ab175559) at 1.0 μg/mL for 1 hour at 4°C. Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
IGN523 (anti-CD98) (Ab175559) - Flow Cytometry Flow Cytometry analysis of MCF7 cells labelling CD98 (red) with IGN523 (anti-CD98) (Ab175559) at 1.0 μg/mL for 1 hour at 4°C. Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
IGN523 (anti-CD98) (Ab175559) - Flow Cytometry Flow Cytometry analysis of K562 cells labelling CD98 (red) with IGN523 (anti-CD98) (Ab175559) at 1.0 μg/mL for 1 hour at 4°C. Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
IGN523 (anti-CD98) (Ab175559) - ELISA Immobilized Recombinant huSLC3A2-ECD-NHis protein at 2.0 μg/mL can bind IGN523 (anti-CD98) (Ab175559) with the EC₅₀ of 3.6 ng/mL.
IGN523 (anti-CD98) (Ab175559) - SEC The purity of IGN523 (anti-CD98) (Ab175559) is more than 95% verified by HPLC.
ZJ24F1113362
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