ExactAb™,低内毒素,已验证,无动物源,无叠氮钠,无载体,重组 级 提供 ≥95%(SDS-PAGE&SEC-HPLC) 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
-80℃储存,避免反复冻融。特低温运输 。请查阅批次 COA 获取详细规格。
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在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
Natalizumab (anti-ITGA4) 是一种重组的人源化 IgG4 单克隆抗体，与 α4β1-整联蛋白 (α4β1-integrin) 结合并阻断其与血管细胞粘附分子 1 (VCAM-1) 的相互作用。Natalizumab (anti-ITGA4) 可用于复发缓解型多发性硬化症和克罗恩氏病的研究。Natalizumab (anti-ITGA4) 也可阻止淋巴细胞进入中枢神经系统，从而防止急性脱髓鞘复发。
Natalizumab (anti-ITGA4) is a recombinant, humanized IgG4 monoclonal antibody, binds to α4β1-integrin and blocks its interaction with vascular cell adhesion molecule-1 (VCAM-1). Natalizumab (anti-ITGA4) can be used for the treatment of relapsing remitting multiple sclerosis and Crohn's disease. Natalizumab (anti-ITGA4) is also the first targeted therapy which blocks an essential mechanism for lymphocyte entry to the CNS and thus prevents acute demyelinating relapses.
Purity
>95% (SDS-PAGE&SEC)
Endotoxin Level
< 1.0EU/mg
Natalizumab (anti-ITGA4) (Ab175611) - Flow Cytometry
Flow Cytometry analysis of Jurkat cells labelling ITGA4 (red) with Natalizumab (anti-ITGA4) (Ab175611). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Natalizumab (anti-ITGA4) (Ab175611) - SEC
The purity of Natalizumab (anti-ITGA4) (Ab175611) is more than 95% verified by HPLC.
Natalizumab (anti-ITGA4) (Ab175611) - Flow Cytometry
Flow Cytometry analysis of Raji cells labelling ITGA4 (red) with Natalizumab (anti-ITGA4) (Ab175611). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Natalizumab (anti-ITGA4) (Ab175611) - Flow Cytometry
Flow Cytometry analysis of U937 cells labelling ITGA4 (red) with Natalizumab (anti-ITGA4) (Ab175611). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Natalizumab (anti-ITGA4) (Ab175611) - Flow Cytometry
Flow Cytometry analysis of HeLa cells labelling ITGA4 (red) with Natalizumab (anti-ITGA4) (Ab175611). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
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通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！
| 批号(Lot Number) | 证书类型 | 货号 |
|---|---|---|
 ZJ24F0606631 |
分析证书 | Ab175611 |
| ZJ24F0606632 |
分析证书 | Ab175611 |
| ZJ24F0606633 |
分析证书 | Ab175611 |
| ZJ25F0319003 |
分析证书 | Ab175611 |
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