货号 (SKU)

包装规格

是否现货

价格

数量

Ab175677-100μg

100μg

现货

Ab175677-1mg

1mg

现货

Ab175677-5mg

5mg

现货

Ab175677-10mg

10mg

期货

基本信息

产品名称	Tigatuzumab (anti-TNFRSF10B), 死亡受体 5 抗体
别名	替加组单抗 \| 替加珠单抗(抗 TNFRSF10B)
英文别名	Fas like protein antibody \| Apoptosis inducing protein TRICK2A/2B antibody \| Apoptosis inducing receptor TRAIL R2 antibody \| CD262 antibody \| CD262 antigen antibody \| Cytotoxic TRAIL receptor 2 antibody \| Death domain containing receptor for TRAIL/Apo 2L
规格或纯度	无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
宿主种属	人(Human)
特异性	TNFRSF10B
种属反应性	人(Human),食蟹猴(Cynomolgus monkey)
偶联	Unconjugated
作用类型	激动剂
作用机制	死亡受体 5 抗体

AI解读

产品属性

克隆类型	重组抗体
Format	Whole IgG
亚型	Human IgG1
轻链亚型	kappa
SDS-PAGE	26.3 kDa (Light Chain) & 49.8 kDa (Heavy Chain), under reducing conditions; 177.0 kDa, under non-reducing conditions.
纯化方法	Protein A purified
纯度	>95%
物理外观	Liquid
储存缓冲液	Supplied as a 0.22 μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂	No
浓度	见COA
储存温度	-80℃储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
CAS编号和信息	918127-53-4
分子类型	抗体

图片

ELISA: Tigatuzumab (anti-TNFRSF10B) (Ab175677)

Tigatuzumab (anti-TNFRSF10B) ( Ab175677 ) - ELISA
Immobilized Human TNFRSF10B/TRAILR2/CD262-Fc at 2.0 μg/mL can bind Tigatuzumab (anti-TNFRSF10B) (Ab175677) with the EC₅₀ of 15.36 ng/mL.

SEC: Tigatuzumab (anti-TNFRSF10B) (Ab175677)

Tigatuzumab (anti-TNFRSF10B) (Ab175677) - SEC
The purity of Tigatuzumab (anti-TNFRSF10B) (Ab175677) is more than 95% verified by HPLC.

关联靶点（人）

TNFRSF10B Tbio 肿瘤坏死因子受体超家族成员 10B(Tumor necrosis factor receptor superfamily member 10B) (0 活性数据)

点击查看靶蛋白信息： TNFRSF10B

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

作用机制

作用机制	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	参考文献

技术规格说明书

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找到3个结果

批号(Lot Number)	证书类型	日期	货号
ZJ24F0404181	分析证书	24-04-07	Ab175677
ZJ24F0404180	分析证书	24-04-07	Ab175677
ZJ24F0404179	分析证书	24-04-07	Ab175677

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参考文献

1. Ohtsuki T, Kikuchi H, Koyano T, Kowithayakorn T, Sakai T, Ishibashi M.. (2009) Death receptor 5 promoter-enhancing compounds isolated from Catimbium speciosum and their enhancement effect on TRAIL-induced apoptosis.. Bioorg Med Chem, 17 (18): (6748-6754). [PMID:19682913] [10.1016/j.bmc.2009.07.041]
2. Kikuchi H, Ohtsuki T, Koyano T, Kowithayakorn T, Sakai T, Ishibashi M.. (2010) Activity of mangosteen xanthones and teleocidin a-2 in death receptor expression enhancement and tumor necrosis factor related apoptosis-inducing ligand assays.. J Nat Prod, 73 (3): (452-455). [PMID:19788289] [10.1021/np900404e]
3. Sheridan, J P JP and 12 more authors.. (1997) Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors.. Science (New York, N.Y.), (8): [PMID:9242611]
4. Screaton, G R GR and 5 more authors.. (1997) TRICK2, a new alternatively spliced receptor that transduces the cytotoxic signal from TRAIL.. Current biology : CB, (1): [PMID:9285725]
5. Walczak, H H and 11 more authors.. (1997) TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL.. The EMBO journal, (1): [PMID:9311998]
6. MacFarlane, M M and 5 more authors.. (1997) Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL.. The Journal of biological chemistry, (10): [PMID:9325248]
7. Wu, G S GS and 14 more authors.. (1997) KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene.. Nature genetics, [PMID:9326928]
8. Schneider, P P and 5 more authors.. (1997) Characterization of two receptors for TRAIL.. FEBS letters, (27): [PMID:9373179]
9. Chaudhary, P M PM and 5 more authors.. (1997) Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-kappaB pathway.. Immunity, [PMID:9430227]
10. Arai, T T and 5 more authors.. (1998) Genomic organization and mutation analyses of the DR5/TRAIL receptor 2 gene in colorectal carcinomas.. Cancer letters, (27): [PMID:10072170]
11. Mongkolsapaya, J J and 6 more authors.. (1999) Structure of the TRAIL-DR5 complex reveals mechanisms conferring specificity in apoptotic initiation.. Nature structural biology, [PMID:10542098]
12. Hymowitz, S G SG and 7 more authors.. (1999) Triggering cell death: the crystal structure of Apo2L/TRAIL in a complex with death receptor 5.. Molecular cell, [PMID:10549288]
13. Hillman, R Tyler RT, Green, Richard E RE and Brenner, Steven E SE.. (2004) An unappreciated role for RNA surveillance.. Genome biology, [PMID:14759258]
14. Yamaguchi, Hirohito H and Wang, Hong-Gang HG.. (2004) CHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cells.. The Journal of biological chemistry, (29): [PMID:15322075]
15. Nusbaum, Chad C and 75 more authors.. (2006) DNA sequence and analysis of human chromosome 8.. Nature, (19): [PMID:16421571]
16. Maddipatla, Sreeram S, Hernandez-Ilizaliturri, Francisco J FJ, Knight, Joy J and Czuczman, Myron S MS.. (2007) Augmented antitumor activity against B-cell lymphoma by a combination of monoclonal antibodies targeting TRAIL-R1 and CD20.. Clinical cancer research : an official journal of the American Association for Cancer Research, (1): [PMID:17671142]
17. Sun, M M, Song, L L, Li, Y Y, Zhou, T T and Jope, R S RS.. (2008) Identification of an antiapoptotic protein complex at death receptors.. Cell death and differentiation, [PMID:18846110]
18. Smith, Wendell W and 17 more authors.. (2013) Human cytomegalovirus glycoprotein UL141 targets the TRAIL death receptors to thwart host innate antiviral defenses.. Cell host & microbe, (13): [PMID:23498957]
19. Nemčovičová, Ivana; Benedict, Chris A and Zajonc, Dirk M.. (2013) Structure of human cytomegalovirus UL141 binding to TRAIL-R2 reveals novel, non-canonical death receptor interactions.. PLoS pathogens, [PMID:23555243]
20. Newson, Joshua P M and 11 more authors.. (2019) Salmonella Effectors SseK1 and SseK3 Target Death Domain Proteins in the TNF and TRAIL Signaling Pathways.. Molecular & cellular proteomics : MCP, [PMID:30902834]
21. Pan, G G and 5 more authors.. (1997) An antagonist decoy receptor and a death domain-containing receptor for TRAIL.. Science (New York, N.Y.), (8): [PMID:9242610]

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Tigatuzumab (anti-TNFRSF10B), 死亡受体 5 抗体

库存信息

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基本信息

AI解读

产品属性

图片

关联靶点（人）

作用机制

技术规格说明书

质检证书（CoA,COO,BSE/TSE 和分析图谱)

相关文档

可替换产品

参考文献

溶液计算器

摩尔浓度计算器

稀释计算器

复溶计算器

Tigatuzumab (anti-TNFRSF10B), 死亡受体 5 抗体

库存信息

库存信息

库存信息

库存信息

基本信息

AI解读

产品属性

图片

关联靶点（人）

作用机制

技术规格说明书

质检证书（CoA,COO,BSE/TSE 和分析图谱)

相关文档

相关产品

可替换产品

参考文献

溶液计算器

摩尔浓度计算器

稀释计算器

复溶计算器