Tisotumab (anti-F3)

    应用:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
功能和特点
  • 宿主种属: 人(Human)
  • 种属反应性: 人(Human), 食蟹猴(Cynomolgus monkey)
  • 亚型: Human IgG1
  • 偶联: Unconjugated
有货

库存信息

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库存信息

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库存信息

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库存信息

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货号 (SKU) 包装规格 是否现货 价格 数量
Ab176310-100μg
100μg 现货 Stock Image
Ab176310-1mg
1mg 现货 Stock Image
Ab176310-5mg
5mg 现货 Stock Image
Ab176310-10mg
10mg 期货 Stock Image

基本信息

产品名称 Tisotumab (anti-F3)
别名 替索妥单抗 | 替雷利珠单抗 | 替索单抗 | 替索单抗 (抗 F3)
英文别名 CD142 antibody | CD142 antigen antibody | Coagulation factor III (thromboplastin tissue factor) antibody | Coagulation factor III antibody | F3 antibody | FLJ17960 antibody | TF antibody | TF_HUMAN antibody | TFA antibody | Thromboplastin antibody | Tissu
规格或纯度 无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
宿主种属 人(Human)
特异性 F3
种属反应性 人(Human),食蟹猴(Cynomolgus monkey)
偶联 Unconjugated

产品属性

克隆类型 重组抗体
Format Whole IgG
亚型 Human IgG1
轻链亚型 kappa
SDS-PAGE 27.1 kDa (Light Chain) & 51.7 kDa (Heavy Chain), under reducing conditions; 184.7 kDa, under non-reducing conditions.
纯化方法 Protein A purified
纯度 >95%
物理外观 Liquid
储存缓冲液 Supplied as a 0.22 μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂 No
浓度 见COA
储存温度 -80℃储存,避免反复冻融
运输条件 超低温冰袋运输
稳定性与储存 在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
CAS编号和信息 1418628-81-5
分子类型 抗体

图片

Tisotumab (anti-F3) (Ab176310) - Flow Cytometry
Flow Cytometry analysis of A431 cells labelling F3 (red) with Tisotumab (anti-F3) (Ab176310). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Tisotumab (anti-F3) (Ab176310) - SEC
The purity of Tisotumab (anti-F3) (Ab176310) is more than 95% verified by HPLC.

关联靶点(人)

F3 Tclin 组织因子(Tissue factor) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)

作用机制

作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献

安全和危险性(GHS)

技术规格说明书

质检证书(CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):
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找到5个结果

批号(Lot Number) 证书类型 日期 货号
ZJ23F1101847 分析证书 25-09-09 Ab176310
ZJ23F1101848 分析证书 25-09-09 Ab176310
ZJ24F0911527 分析证书 24-09-30 Ab176310
ZJ24F0911526 分析证书 24-09-30 Ab176310
ZJ24F0911528 分析证书 24-09-30 Ab176310

参考文献

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10. Zhang X, Glunz PW, Johnson JA, Jiang W, Jacutin-Porte S, Ladziata V, Zou Y, Phillips MS, Wurtz NR, Parkhurst B, Rendina AR, Harper TM, Cheney DL, Luettgen JM, Wong PC, Seiffert D, Wexler RR, Priestley ES..  (2016)  Discovery of a Highly Potent, Selective, and Orally Bioavailable Macrocyclic Inhibitor of Blood Coagulation Factor VIIa-Tissue Factor Complex..  J Med Chem,  59  (15): (7125-7137).  [PMID:27455395] [10.1021/acs.jmedchem.6b00469]
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