| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| Ab176554-100μg |
100μg |
现货  |
| |
| Ab176554-1mg |
1mg |
现货 |
| |
| Ab176554-5mg |
5mg |
现货 |
| |
| Ab176554-10mg |
10mg |
期货 |
|
| 产品名称 | Mogamulizumab (anti-CCR4), C-C 趋化因子受体 4 型交联剂的交联剂 |
|---|---|
| 别名 | 莫格利珠单抗 | 莫格利组单抗 | 莫加莫利珠单抗（抗CCR4） |
| 英文别名 | C C chemokine receptor type 4 antibody | C C CKR 4 antibody | C-C chemokine receptor type 4 antibody | C-C CKR-4 antibody | CC CKR 4 antibody | CC-CKR-4 antibody | CCR 4 antibody | CCR-4 antibody | CCR4 antibody | CCR4_HUMAN antibody | CD194 antibody | Ch |
| 规格或纯度 | 无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA |
| 宿主种属 | 人(Human) |
| 特异性 | CCR4 |
| 种属反应性 | 人(Human) |
| 偶联 | Unconjugated |
| 作用类型 | 交联剂 |
| 作用机制 | C-C 趋化因子受体 4 型交联剂的交联剂 |
| 克隆类型 | 重组抗体 |
|---|---|
| Format | Whole IgG |
| 亚型 | Human IgG1 |
| 轻链亚型 | kappa |
| SDS-PAGE | 27.0 kDa (Light Chain) & 50.8 kDa (Heavy Chain), under reducing conditions; 184.7 kDa, under non-reducing conditions. |
| 纯化方法 | Protein A purified |
| 纯度 | >95% |
| 物理外观 | Liquid |
| 储存缓冲液 | Supplied as a 0.22μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0 |
| 防腐剂 | No |
| 浓度 | 见COA |
| 储存温度 | -80℃储存,避免反复冻融 |
| 运输条件 | 超低温冰袋运输 |
| 稳定性与储存 | 在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。 |
| CAS编号和信息 | 1159266-37-1 |
| 分子类型 | 抗体 |
Mogamulizumab (anti-CCR4) (Ab176554) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling CCR4 with Mogamulizumab (anti-CCR4) (Ab176554) conjugated with biotin (right panel) compared with Human IgG (Ab170213) conjugated with biotin - Isotype Control (left panel) and detected with SA-PE (rp156150).
Mogamulizumab (anti-CCR4) (Ab176554) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling CCR4 (red) with Mogamulizumab (anti-CCR4) (Ab176554) conjugated with biotin and detected with SA-PE (rp156150). Blue - Isotype control, human IgG (Ab170213) conjugated with biotin. Black - Unlabelled control, cells without incubation with primary antibody.
Mogamulizumab (anti-CCR4) (Ab176554) - SEC
The purity of Mogamulizumab (anti-CCR4) (Ab176554) is more than 95% verified by HPLC.
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！
| 批号(Lot Number) | 证书类型 | 日期 | 货号 |
|---|---|---|---|
 ZJ24F1214915 |
分析证书 | 24-12-06 | Ab176554 |
| ZJ24F1214914 |
分析证书 | 24-12-06 | Ab176554 |
| ZJ24F1214913 |
分析证书 | 24-12-06 | Ab176554 |
| ZJ23F1202068 |
分析证书 | 23-12-20 | Ab176554 |
| ZJ23F1202069 |
分析证书 | 23-12-20 | Ab176554 |
| 1. Naya A, Sagara Y, Ohwaki K, Saeki T, Ichikawa D, Iwasawa Y, Noguchi K, Ohtake N.. (2001) Design, synthesis, and discovery of a novel CCR1 antagonist.. J Med Chem, 44 (9): (1429-1435). [PMID:11311066] [10.1021/jm0004244] |
| 2. Kato H, Tsuchiya N, Izumi S, Miyamasu M, Nakajima T, Kawasaki H, Hirai K, Tokunaga K. (1999) New variations of human CC-chemokine receptors CCR3 and CCR4.. Genes Immun, 1 (2): (97-104). [PMID:11196669] [10.1021/op500134e] |
| 3. Imai T, Chantry D, Raport CJ, Wood CL, Nishimura M, Godiska R, Yoshie O, Gray PW. (1998) Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4.. J Biol Chem, 273 (3): (1764-8). [PMID:9430724] [10.1021/op500134e] |
| 4. Campbell JJ, Haraldsen G, Pan J, Rottman J, Qin S, Ponath P, Andrew DP, Warnke R, Ruffing N, Kassam N et al.. (1999) The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells.. Nature, 400 (6746): (776-80). [PMID:10466728] [10.1021/op500134e] |
| 5. Thoma G, Streiff MB, Kovarik J, Glickman F, Wagner T, Beerli C, Zerwes HG. (2008) Orally bioavailable isothioureas block function of the chemokine receptor CXCR4 in vitro and in vivo.. J Med Chem, 51 (24): (7915-20). [PMID:19053768] [10.1021/op500134e] |
| 6. Carter PH, Liu RQ, Foster WR, Tamasi JA, Tebben AJ, Favata M, Staal A, Cvijic ME, French MH, Dell V et al.. (2007) Discovery of a small molecule antagonist of the parathyroid hormone receptor by using an N-terminal parathyroid hormone peptide probe.. Proc Natl Acad Sci USA, 104 (16): (6846-51). [PMID:17428923] [10.1021/op500134e] |
| 7. Antoniu SA. (2010) Mogamulizumab, a humanized mAb against C-C chemokine receptor 4 for the potential treatment of T-cell lymphomas and asthma.. Curr Opin Mol Ther, 12 (6): (770-9). [PMID:21154168] [10.1021/op500134e] |
| 8. Santella 3rd JB, Gardner DS, Duncia JV, Wu H, Dhar M, Cavallaro C, Tebben AJ, Carter PH, Barrish JC, Yarde M et al.. (2014) Discovery of the CCR1 antagonist, BMS-817399, for the treatment of rheumatoid arthritis.. J Med Chem, 57 (18): (7550-64). [PMID:25101488] [10.1021/op500134e] |
| 9. Jackson JJ, Ketcham JM, Younai A, Abraham B, Biannic B, Beck HP, Bui MHT, Chian D, Cutler G, Diokno R et al.. (2019) Discovery of a Potent and Selective CCR4 Antagonist That Inhibits Treg Trafficking into the Tumor Microenvironment.. J Med Chem, 62 (13): (6190-6213). [PMID:31259550] [10.1021/op500134e] |
| 10. Angst D, Gessier F, Janser P, Vulpetti A, Wälchli R, Beerli C, Littlewood-Evans A, Dawson J, Nuesslein-Hildesheim B, Wieczorek G et al.. (2020) Discovery of LOU064 (Remibrutinib), a Potent and Highly Selective Covalent Inhibitor of Bruton's Tyrosine Kinase.. J Med Chem, 63 (10): (5102-5118). [PMID:32083858] [10.1021/op500134e] |
| 11. Lagu B, Gerchak C, Pan M, Hou C, Singer M, Malaviya R, Matheis M, Olini G, Cavender D, Wachter M.. (2007) Potent and selective CC-chemokine receptor-2 (CCR2) antagonists as a potential treatment for asthma.. Bioorg Med Chem Lett, 17 (15): (4382-4386). [PMID:17587570] [10.1016/j.bmcl.2007.01.115] |
| 12. Yokoyama K, Ishikawa N, Igarashi S, Kawano N, Masuda N, Hattori K, Miyazaki T, Ogino S, Orita M, Matsumoto Y, Takeuchi M, Ohta M.. (2008) Potent CCR4 antagonists: synthesis, evaluation, and docking study of 2,4-diaminoquinazolines.. Bioorg Med Chem, 16 (17): (7968-7974). [PMID:18694645] [10.1016/j.bmc.2008.07.062] |
| 13. Merritt JR, Liu J, Quadros E, Morris ML, Liu R, Zhang R, Jacob B, Postelnek J, Hicks CM, Chen W, Kimble EF, Rogers WL, O'Brien L, White N, Desai H, Bansal S, King G, Ohlmeyer MJ, Appell KC, Webb ML.. (2009) Novel pyrrolidine ureas as C-C chemokine receptor 1 (CCR1) antagonists.. J Med Chem, 52 (5): (1295-1301). [PMID:19183043] [10.1021/jm801416q] |
| 14. Li G, Wang D, Sun M, Li G, Hu J, Zhang Y, Yuan Y, Ji H, Chen N, Liu G.. (2010) Discovery and optimization of novel 3-piperazinylcoumarin antagonist of chemokine-like factor 1 with oral antiasthma activity in mice.. J Med Chem, 53 (4): (1741-1754). [PMID:20099827] [10.1021/jm901652p] |
| 15. Laborde E, Macsata RW, Meng F, Peterson BT, Robinson L, Schow SR, Simon RJ, Xu H, Baba K, Inagaki H, Ishiwata Y, Jomori T, Matsumoto Y, Miyachi A, Nakamura T, Okamoto M, Handel TM, Bernard CC.. (2011) Discovery, optimization, and pharmacological characterization of novel heteroaroylphenylureas antagonists of C-C chemokine ligand 2 function.. J Med Chem, 54 (6): (1667-1681). [PMID:21341682] [10.1021/jm1012903] |
| 16. Smethurst CA, Bevan N, Brooks C, Emmons A, Gough PJ, Mookherjee C, Moores K, Peace S, Philp J, Piercy V, Watson SP, Zippoli M.. (2012) In vivo activity of an azole series of CCR2 antagonists.. Bioorg Med Chem Lett, 22 (23): (7252-7255). [PMID:23079519] [10.1016/j.bmcl.2012.09.020] |
| 17. Karlström S, Nordvall G, Sohn D, Hettman A, Turek D, Åhlin K, Kers A, Claesson M, Slivo C, Lo-Alfredsson Y, Petersson C, Bessidskaia G, Svensson PH, Rein T, Jerning E, Malmberg Å, Ahlgen C, Ray C, Vares L, Ivanov V, Johansson R.. (2013) Substituted 7-amino-5-thio-thiazolo[4,5-d]pyrimidines as potent and selective antagonists of the fractalkine receptor (CX3CR1).. J Med Chem, 56 (8): (3177-3190). [PMID:23516963] [10.1021/jm3012273] |
| 18. Skerlj R, Bridger G, Zhou Y, Bourque E, McEachern E, Metz M, Harwig C, Li TS, Yang W, Bogucki D, Zhu Y, Langille J, Veale D, Ba T, Bey M, Baird I, Kaller A, Krumpak M, Leitch D, Satori M, Vocadlo K, Guay D, Nan S, Yee H, Crawford J, Chen G, Wilson T, Carpenter B, Gauthier D, Macfarland R, Mosi R, Bodart V, Wong R, Fricker S, Schols D.. (2013) Design of substituted imidazolidinylpiperidinylbenzoic acids as chemokine receptor 5 antagonists: potent inhibitors of R5 HIV-1 replication.. J Med Chem, 56 (20): (8049-8065). [PMID:24090135] [10.1021/jm401101p] |
| 19. Power, C A CA and 6 more authors.. (1995) Molecular cloning and functional expression of a novel CC chemokine receptor cDNA from a human basophilic cell line.. The Journal of biological chemistry, (18): [PMID:7642634] |
| 20. Imai, T T and 5 more authors.. (1997) The T cell-directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4.. The Journal of biological chemistry, (6): [PMID:9169480] |
| 21. Inngjerdingen, M M, Damaj, B B and Maghazachi, A A AA.. (2000) Human NK cells express CC chemokine receptors 4 and 8 and respond to thymus and activation-regulated chemokine, macrophage-derived chemokine, and I-309.. Journal of immunology (Baltimore, Md. : 1950), (15): [PMID:10754297] |
| 22. Beck, Alain and Reichert, Janice M.. Marketing approval of mogamulizumab: a triumph for glyco-engineering.. mAbs, [PMID:22699226] |
首页
400-620-6333
