| 货号 (SKU) | 包装规格 | 是否现货 | 价格 | 数量 |
|---|---|---|---|---|
| Ab179387-100μg |
100μg |
现货  |
| |
| Ab179387-1mg |
1mg |
现货 |
| |
| Ab179387-5mg |
5mg |
现货 |
| |
| Ab179387-10mg |
10mg |
期货 |
|
| 产品名称 | BAY 1158061 (anti-PRLR) |
|---|---|
| 别名 | 泌乳素受体单克隆抗体 |
| 英文别名 | AI987712 antibody | CLONE SPM213 antibody | CPRLP antibody | Delta 4-delta 7/11 truncated prolactin receptor antibody | Delta 4-SF1b truncated prolactin receptor antibody | HPRL antibody | hPRL receptor antibody | hPRLrI antibody | Lactogen receptor antib |
| 规格或纯度 | 无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA |
| 宿主种属 | 人(Human) |
| 特异性 | PRLR |
| 种属反应性 | 人(Human),小鼠(Mouse) |
| 偶联 | Unconjugated |
| 克隆类型 | 重组抗体 |
|---|---|
| Format | Whole IgG |
| 亚型 | Human IgG1 |
| 轻链亚型 | lambda |
| SDS-PAGE | 27.8 kDa (Light Chain) & 50.4 kDa (Heavy Chain), under reducing conditions; 181.7 kDa, under non-reducing conditions. |
| 纯化方法 | Protein A purified |
| 纯度 | >95% |
| 物理外观 | Liquid |
| 储存缓冲液 | Supplied as a 0.22μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0 |
| 防腐剂 | No |
| 浓度 | 见COA |
| 储存温度 | -80℃储存,避免反复冻融 |
| 运输条件 | 超低温冰袋运输 |
| 稳定性与储存 | 在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。 |
| 分子类型 | 抗体 |
BAY 1158061 (anti-PRLR) (Ab179387) - Flow Cytometry
Flow Cytometry analysis of Hela cells labelling PRLR (red) with BAY 1158061 (anti-PRLR) (Ab179387). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
BAY 1158061 (anti-PRLR) (Ab179387) - SEC
The purity of BAY 1158061 (anti-PRLR) (Ab179387) is more than 95% verified by HPLC.
BAY 1158061 (anti-PRLR) (Ab179387) - ELISA
Immobilized T Human PRLR / Prolactin Receptor-his at 2.0 μg/mL can bind BAY 1158061 (anti-PRLR) (Ab179387) with the EC₅₀ of 6.58 ng/mL.
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！
| 批号(Lot Number) | 证书类型 | 日期 | 货号 |
|---|---|---|---|
 ZJ24F0404278 |
分析证书 | 24-04-10 | Ab179387 |
| ZJ24F0404277 |
分析证书 | 24-04-10 | Ab179387 |
| ZJ24F0404276 |
分析证书 | 24-04-10 | Ab179387 |
¥979.90
| 1. Newey PJ, Gorvin CM, Cleland SJ, Willberg CB, Bridge M, Azharuddin M, Drummond RS, van der Merwe PA, Klenerman P, Bountra C et al.. (2013) Mutant prolactin receptor and familial hyperprolactinemia.. N Engl J Med, 369 (21): (2012-20). [PMID:24195502] [10.1021/op500134e] |
| 2. Bogorad RL, Courtillot C, Mestayer C, Bernichtein S, Harutyunyan L, Jomain JB, Bachelot A, Kuttenn F, Kelly PA, Goffin V et al.. (2008) Identification of a gain-of-function mutation of the prolactin receptor in women with benign breast tumors.. Proc Natl Acad Sci USA, 105 (38): (14533-8). [PMID:18779591] [10.1021/op500134e] |
| 3. Boutin, J M JM and 8 more authors.. (1989) Identification of a cDNA encoding a long form of prolactin receptor in human hepatoma and breast cancer cells.. Molecular endocrinology (Baltimore, Md.), [PMID:2558309] |
| 4. Fuh, G G and Wells, J A JA.. (1995) Prolactin receptor antagonists that inhibit the growth of breast cancer cell lines.. The Journal of biological chemistry, (2): [PMID:7768908] |
| 5. Somers, W W, Ultsch, M M, De Vos, A M AM and Kossiakoff, A A AA.. (1994) The X-ray structure of a growth hormone-prolactin receptor complex.. Nature, (1): [PMID:7984244] |
| 6. Hu, Z Z ZZ, Zhuang, L L, Meng, J J, Leondires, M M and Dufau, M L ML.. (1999) The human prolactin receptor gene structure and alternative promoter utilization: the generic promoter hPIII and a novel human promoter hP(N).. The Journal of clinical endocrinology and metabolism, [PMID:10084611] |
| 7. Kline, J B JB, Roehrs, H H and Clevenger, C V CV.. (1999) Functional characterization of the intermediate isoform of the human prolactin receptor.. The Journal of biological chemistry, (10): [PMID:10585417] |
| 8. Hu, Z Z ZZ, Meng, J J and Dufau, M L ML.. (2001) Isolation and characterization of two novel forms of the human prolactin receptor generated by alternative splicing of a newly identified exon 11.. The Journal of biological chemistry, (2): [PMID:11518703] |
| 9. Kline, J Bradford JB, Rycyzyn, Michael A MA and Clevenger, Charles V CV.. (2002) Characterization of a novel and functional human prolactin receptor isoform (deltaS1PRLr) containing only one extracellular fibronectin-like domain.. Molecular endocrinology (Baltimore, Md.), [PMID:12351696] |
| 10. Trott, J F JF, Hovey, R C RC, Koduri, S S and Vonderhaar, B K BK.. (2003) Alternative splicing to exon 11 of human prolactin receptor gene results in multiple isoforms including a secreted prolactin-binding protein.. Journal of molecular endocrinology, [PMID:12580759] |
| 11. Miller, Sommer L SL, DeMaria, Jamie E JE, Freier, David O DO, Riegel, Angela M AM and Clevenger, Charles V CV.. (2005) Novel association of Vav2 and Nek3 modulates signaling through the human prolactin receptor.. Molecular endocrinology (Baltimore, Md.), [PMID:15618286] |
| 12. Walsh, Scott T R ST and Kossiakoff, Anthony A AA.. (2006) Crystal structure and site 1 binding energetics of human placental lactogen.. Journal of molecular biology, (5): [PMID:16546209] |
| 13. Lazzaro, Maribeth A MA and 5 more authors.. (2006) The imitation switch protein SNF2L regulates steroidogenic acute regulatory protein expression during terminal differentiation of ovarian granulosa cells.. Molecular endocrinology (Baltimore, Md.), [PMID:16740656] |
| 14. Ahmed, Tamer A TA and 7 more authors.. (2007) Interleukin-6 inhibits growth hormone-mediated gene expression in hepatocytes.. American journal of physiology. Gastrointestinal and liver physiology, [PMID:17395896] |
| 15. Pujianto, Dwi Ari DA, Curry, Benjamin J BJ and Aitken, R John RJ.. (2010) Prolactin exerts a prosurvival effect on human spermatozoa via mechanisms that involve the stimulation of Akt phosphorylation and suppression of caspase activation and capacitation.. Endocrinology, [PMID:20032052] |
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