计算溶液所需的质量、体积或浓度。
Vilobelimab (anti-Complement C5) (Ab182712) - ELISA
Immobilized Human Complement C5 Protein at 2.0 μg/mL can bind Vilobelimab (anti-Complement C5) (Ab182712) with the EC₅₀ of 69.06 ng/mL.
ExactAb™,低内毒素,已验证,无动物源,无叠氮钠,无载体,重组 级 提供 ≥95%(SDS-PAGE&SEC-HPLC) 纯度,适用于对基线干扰要求严格的色谱和分析工作流程。
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在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
Vilobelimab (anti-Complement C5) 是一种单克隆抗 C5a 抗体,过敏毒素 C5a 是一种促炎补体分裂产物,在介导器官功能障碍中起核心作用。Vilobelimab (anti-Complement C5) 可作为一种 C5a 抑制剂,抑制中性粒细胞活化、趋化性,减少炎症信号等,可用于败血症,COVID-19 等相关研究。
Vilobelimab (anti-Complement C5) is a monoclonal anti-C5a antibody to the allergen C5a, a pro-inflammatory complement division product that plays a central role in mediating organ dysfunction. Vilobelimab (anti-Complement C5) acts as a C5a inhibitor, inhibiting neutrophil activation, chemotaxis, and reducing inflammatory signalling, and may be used in studies related to sepsis, COVID-19, etc.
Purity
≥95% (SDS-PAGE&SEC)
Endotoxin Level
≤1.0EU/mg
Protein Function
Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled.
Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. C5a also stimulates the locomotion of polymorphonuclear leukocytes (chemokinesis) and direct their migration toward sites of inflammation (chemotaxis).
Vilobelimab (anti-Complement C5) (Ab182712) - ELISA
Immobilized Human Complement C5 Protein at 2.0 μg/mL can bind Vilobelimab (anti-Complement C5) (Ab182712) with the EC₅₀ of 69.06 ng/mL.
Vilobelimab (anti-Complement C5) (Ab182712) - SEC
The purity of Vilobelimab (anti-Complement C5) (Ab182712) is more than 95% verified by HPLC.
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
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| 批号(Lot Number) | 证书类型 | 货号 |
|---|---|---|
| 分析证书 | Ab182712 | |
| 分析证书 | Ab182712 | |
| 分析证书 | Ab182712 |
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