Abrilumab (anti-Integrin a4b7 (ITGA4&ITGB7)) is a fully human monoclonal antibody directed against α4β7. Abrilumab (anti-Integrin a4b7 (ITGA4&ITGB7)) selectively binds the α4β7 integrin heterodimer. Abrilumab (anti-Integrin a4b7 (ITGA4&ITGB7)) can be used for the research of inflammatory bowel disease (IBD).
269C wild type antibody | Antigen CD49D, alpha 4 subunit of VLA 4 receptor antibody | CD49 antigen like family member D antibody | CD49 antigen-like family member D antibody | CD49d antibody | IA4 antibody | Integrin alpha 4 antibody | Integrin alpha 4 su
ITGA4: Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells.
ITGB7: Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT). Integrin alpha-4/beta-7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract. Interacts also with VCAM1 and fibronectin, an extracellular matrix component. It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Interactions involves the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin. Binds to HIV-1 gp120, thereby allowing the virus to enter GALT, which is thought to be the major trigger of AIDS disease. Interaction would involve a tripeptide L-D-I in HIV-1 gp120. Integrin alpha-E/beta-7 (HML-1) is a receptor for E-cadherin.
宿主种属
人(Human)
特异性
Integrin a4b7 (ITGA4&ITGB7)
种属反应性
人(Human)
偶联
Unconjugated
作用类型
抑制剂
作用机制
Integrin alpha-4/beta-7 抑制剂
克隆类型
重组抗体
Format
Whole IgG
亚型
Human IgG2SA
轻链亚型
kappa
纯化方法
Protein A purified
浓度
见COA
CAS编号和信息
1342290-43-0
分子类型
抗体
产品线
生物产品
储存与运输
储存缓冲液
Supplied as a 0.22 μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂
No
储存条件
-80℃储存,避免反复冻融
运输条件
特低温运输
稳定性与储存
在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
图片
Abrilumab (anti-Integrin α4β7) (Ab182732) - Flow Cytometry Flow Cytometry analysis of human peripheral blood lymphocytes labelling Integrin α4β7 with Abrilumab (anti-Integrin α4β7) (Ab182732) conjugated with biotin (right panel) compared with Human IgG (Biotin) (Ab180314) - Isotype Control (left panel) and detected with SA-PE (rp156150).
Abrilumab (anti-Integrin α4β7) (Ab182732) - Flow Cytometry Flow Cytometry analysis of human peripheral blood lymphocytes labelling Integrin α4β7 (red) with Abrilumab (anti-Integrin α4β7) (Ab182732) conjugated with biotin and detected with SA-PE (rp156150). Blue - Isotype control, Human IgG (Biotin) (Ab180314). Black - Unlabelled control, cells without incubation with primary antibody.
Abrilumab (anti-Integrin α4β7) (Ab182732) - Flow Cytometry Flow Cytometry analysis of Jurkat cells labelling Integrin α4β7 (red) with Abrilumab (anti-Integrin α4β7) (Ab182732) at 1.0 μg/mL for 1 hour at 4°C. Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Abrilumab (anti-Integrin α4β7) (Ab182732) - Flow Cytometry Flow Cytometry analysis of THP-1 cells labelling Integrin α4β7 (red) with Abrilumab (anti-Integrin α4β7) (Ab182732) at 1.0 μg/mL for 1 hour at 4°C. Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Abrilumab (anti-Integrin α4β7) (Ab182732) - ELISA Immobilized Recombinant Human Integrin alpha 4 beta 7 (ITGA4&ITGB7) Heterodimer protein at 2.0 μg/mL can bind Abrilumab (anti-Integrin α4β7) (Ab182732) with the EC50 of 4.74 ng/mL.
Abrilumab (anti-Integrin α4β7) (Ab182732) - SEC The purity of Abrilumab (anti-Integrin α4β7) (Ab182732) is more than 95% verified by HPLC.
ZJ24F1114367
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