ExactAb™,低内毒素,已验证,无动物源,无叠氮钠,无载体,重组 级 提供 ≥95%(SDS-PAGE&SEC-HPLC) 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
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在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
Surzebiclimab (anti-TIM-3) 是一种人源化 IgG1 变体单克隆抗体，抗 T 细胞免疫球蛋白和含粘蛋白结构域 3 (TIM-3)。Surzebiclimab (anti-TIM-3) 与人 Tim-3 细胞外结构域结合具有较高的亲和力 (KD=0.36 nM) 和特异性。Surzebiclimab (anti-TIM-3) 可用于癌症研究。
Surzebiclimab (anti-TIM-3) is a humanized IgG1-variant monoclonal antibody against T-cell immunoglobulin and mucin-domain containing-3 (TIM-3). Surzebiclimab (anti-TIM-3) binds to the extracellular domain of human Tim-3 with high affinity (KD=0.36 nM) and specificity. Surzebiclimab (anti-TIM-3) can be used in research of cancer.
Purity
>95% (SDS-PAGE&SEC)
Endotoxin Level
< 1.0EU/mg
Surzebiclimab (anti-TIM-3) (Ab182869) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood monocytes labelling TIM-3 with Surzebiclimab (anti-TIM-3) (Ab182869) conjugated with biotin (right panel) compared with Human IgG (Biotin) (Ab180314) - Isotype Control (left panel) and detected with SA-PE (rp156150).
Surzebiclimab (anti-TIM-3) (Ab182869) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood monocytes labelling TIM-3 (red) with Surzebiclimab (anti-TIM-3) (Ab182869) conjugated with biotin and detected with SA-PE (rp156150). Blue - Isotype control, Human IgG (Biotin) (Ab180314). Black - Unlabelled control, cells without incubation with primary antibody.
Surzebiclimab (anti-TIM-3) (Ab182869) - ELISA
Immobilized Recombinant Human TIM-3 Protein (rp176703) at 1.0 μg/mL can bind Surzebiclimab (anti-TIM-3) (Ab182869) with the EC50 of 15.3 ng/mL.
Surzebiclimab (anti-TIM-3) (Ab182869) - SEC
The purity of Surzebiclimab (anti-TIM-3) (Ab182869) is more than 95% verified by HPLC.
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
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| 批号(Lot Number) | 证书类型 | 货号 |
|---|---|---|
 ZJ24F0506000 |
分析证书 | Ab182869 |
| ZJ24F0506001 |
分析证书 | Ab182869 |
| ZJ24F0506002 |
分析证书 | Ab182869 |
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