Vobramitamab (anti-CD276)

CAS: 2490556-50-6 货号: Ab182976
有货
级别和纯度: 无动物源 ? 无动物源(Animal Free)—— 不含动物源成分生产,降低污染风险。适用于避免动物源材料的生物制造和培养。 无载体 ? 无载体(Carrier Free)—— 不含添加的载体蛋白/稳定剂。当载体(如 BSA)会干扰偶联或敏感检测时使用。 重组 ? 重组(Recombinant)—— 通过重组表达生产,序列确定、批次稳定。适用于来源明确、无动物源的可重现蛋白。 ExactAb™ ? ExactAb™ —— 阿拉丁强调精准和验证质量的抗体系列。适用于可靠、特异性经验证的抗体应用。 低内毒素 ? 低内毒素级 —— 内毒素降至受控低水平。适用于高内毒素会造成干扰的敏感生物工作。 无叠氮钠 ? 无叠氮(Azide Free)—— 不含叠氮化钠防腐剂。适用于叠氮有毒或有抑制作用的偶联、细胞工作或检测。 已验证 ? 已验证级 —— 发布前在特定应用中确认性能。当需要试剂按声称工作的书面保证时使用。 ≥95%(SDS-PAGE&SEC-HPLC) 见COA
应用
Animal Model, ELISA, Flow Cytometry, Functional Assay
宿主种属
人(Human)
种属反应性
人(Human)
亚型
Human IgG1
偶联
Unconjugated
★
规格
库存
价格
数量
100μg
Ab182976-100μg
现货 Stock Image
¥539.90
1mg
Ab182976-1mg
现货 Stock Image
¥2,699.90
5mg
Ab182976-5mg
现货 Stock Image
¥6,749.90
10mg
Ab182976-10mg
期货 Stock Image
¥14,399.90
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为什么选择此级别

ExactAb™,低内毒素,已验证,无动物源,无叠氮钠,无载体,重组 级 提供 ≥95%(SDS-PAGE&SEC-HPLC) 纯度,适用于对基线干扰要求严格的色谱和分析工作流程。

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储存与运输

-80℃储存,避免反复冻融。特低温运输 。请查阅批次 COA 获取详细规格。

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质量文档

SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。

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文献证明

在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。

概述

Vobramitamab (anti-CD276) 是人源 B7-H3 单克隆抗体 (mAb)。Vobramitamab (anti-CD276) 通过可切割的连接物与前药 seco-DUBA 结合,形成抗体-药物偶联物 (ADC) MGC018。

Vobramitamab (anti-CD276) is a humanized B7-H3 monoclonal antibody (mAb). Vobramitamab (anti-CD276) conjugated with prodrug seco-DUBA via a cleavable linker, to form antibody-drug conjugate (ADC), the MGC018.

规格

产品名称
Vobramitamab (anti-CD276)
英文别名
4Ig-B7-H3 antibody | AU016588 antibody | B7 H3 antibody | B7 homolog 3 antibody | B7-H3 antibody | B7H3 antibody | B7RP-2 antibody | CD_antigen=CD276 antibody | CD276 antibody | CD276 antigen antibody | CD276 molecule antibody | CD276_HUMAN antibody | Cos
规格或纯度
无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
生化机理
May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling.
宿主种属
人(Human)
特异性
CD276
种属反应性
人(Human)
偶联
Unconjugated
克隆类型
重组抗体
Format
Whole IgG
亚型
Human IgG1
轻链亚型
kappa
纯化方法
Protein A purified
浓度
见COA
CAS编号和信息
2490556-50-6
分子类型
抗体
产品线
生物产品
储存与运输
储存缓冲液
Supplied as a 0.22μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂
No
储存条件
-80℃储存,避免反复冻融
运输条件
特低温运输
稳定性与储存
在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
图片

Vobramitamab (anti-CD276) (Ab182976) - Flow Cytometry
Flow Cytometry analysis of MCF7 cells labelling CD276 (red) with Vobramitamab (anti-CD276) (Ab182976) at 1.0 μg/mL for 1 hour at 4°C. Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Vobramitamab (anti-CD276) (Ab182976) - ELISA
Immobilized Recombinant Human CD276 protein (rp143912) at 1.0 μg/mL can bind Vobramitamab (anti-CD276) (Ab182976) with the EC50 of 16.75 ng/mL.

Vobramitamab (anti-CD276) (Ab182976) - SEC
The purity of Vobramitamab (anti-CD276) (Ab182976) is more than 95% verified by HPLC.

技术文档

📋 安全数据表 (SDS)

全面的危险、操作、储存及法规合规文件。

下载 SDS →

✅ 分析证书 (COA)

批次质量数据。输入批号以获取对应 COA。

查询 COA →

📊 产品数据表

产品规格和应用的快速参考摘要。

查看数据表 →

🔬 规格说明书

该级别的完整质量属性和验收标准。

查看规格说明 →

高级数据

关联靶点(人)
CD276 Tbio CD276抗原(CD276 antigen) (0 活性数据)
活性类型 活性值-log(M) 作用机制 期刊 参考文献(PubMed IDs)
作用机制
作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献
质检证书(CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:

通过匹配包装上的批号来查找并下载产品的 COA,每批产品都进行了严格的验证,您可放心使用!

找到3个结果

批号(Lot Number) 证书类型 货号
ZJ24F1113694 分析证书 Ab182976
ZJ24F1113695 分析证书 Ab182976
ZJ24F1113696 分析证书 Ab182976
溶液计算器

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