ExactAb™,低内毒素,已验证,无动物源,无叠氮钠,无载体,重组 级 提供 ≥95%(SDS-PAGE&SEC-HPLC) 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
-80℃储存,避免反复冻融。特低温运输 。请查阅批次 COA 获取详细规格。
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在色谱分析、有机合成和交叉偶联反应领域已被 1 篇同行评审文献引用。
Abciximab (anti-Integrin αIIbβ3) 是一种小鼠/人嵌合单克隆抗体，是一种糖蛋白 IIb/IIIa (glycoprotein IIb/IIIa) 抑制剂。Abciximab (anti-Integrin αIIbβ3) 通过与糖蛋白 IIb/IIIa、vitronectin 和 Mac-1 受体结合抑制血小板聚集和白细胞粘附。
Abciximab (anti-Integrin αIIbβ3), a chimeric mouse/human monoclonal antibody, is a glycoprotein (GP) IIb/IIIa inhibitor. Abciximab (anti-Integrin αIIbβ3) inhibits platelet aggregation and leucocyte adhesion by binding to the glycoprotein IIb/IIIa, vitronectin and Mac-1 receptors.
Purity
≥95% (SDS-PAGE&SEC)
Endotoxin Level
≤1.0EU/mg
Protein Function
ITGA2B: Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.
ITGB3: Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
Abciximab (anti-Integrin αIIbβ3) (Ab183009) - ELISA
Immobilized Recombinant Human Integrin alpha 2b beta 3(ITGAIIb&ITGB3) Heterodimer protein at 2.0 μg/mL can bind Abciximab (anti-Integrin αIIbβ3) (Ab183009) with the EC₅₀ of 555.4 ng/mL.
Abciximab (anti-Integrin αIIbβ3) (Ab183009) - SEC
The purity of Abciximab (anti-Integrin αIIbβ3) (Ab183009) is more than 95% verified by HPLC.
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| 批号(Lot Number) | 证书类型 | 货号 |
|---|---|---|
 ZJ24F1012015 |
分析证书 | Ab183009 |
| ZJ24F1012016 |
分析证书 | Ab183009 |
| ZJ24F1012017 |
分析证书 | Ab183009 |
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