ExactAb™,低内毒素,已验证,无动物源,无叠氮钠,无载体,重组 级 提供 ≥90%(SDS-PAGE&SEC-HPLC) 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
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在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
atritumab deruxtecan (anti-ERBB3) 是一种抗体-活性分子偶联物 (ADC)，由全人抗 HER3 IgG1 单克隆抗体 Patritumab 通过基于四肽的可裂解接头连接到拓扑异构酶 I 抑制剂有效载荷组成。
Patritumab deruxtecan (anti-ERBB3) is an antibody-drug conjugate (ADC) consisting of a fully human anti-HER3 IgG1 monoclonal antibody Patritumab attached to a topoisomerase I inhibitor payload via a tetrapeptide-based cleavable linker. Patritumab deruxtecan shows anticancer activity.
Purity
>90% (SDS-PAGE&SEC)
Endotoxin Level
< 1.0EU/mg
Patritumab deruxtecan (anti-ERBB3) (Ab183315) - Flow Cytometry
Flow Cytometry analysis of MCF-7 cells labelling ERBB3 (red) with Patritumab deruxtecan (anti-ERBB3) (Ab183315). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Patritumab deruxtecan (anti-ERBB3) (Ab183315) - Flow Cytometry
Flow Cytometry analysis of A431 cells labelling ERBB3 (red) with Patritumab deruxtecan (anti-ERBB3) (Ab183315). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Patritumab deruxtecan (anti-ERBB3) (Ab183315) - ELISA
Immobilized Recombinant Human ERBB3 protein (rp170123) at 1.0 μg/mL can bind Patritumab deruxtecan (anti-ERBB3) (Ab183315) with the EC₅₀ of 24.89 ng/mL.
Patritumab deruxtecan (anti-ERBB3) (Ab183315) - SEC
The purity of Patritumab deruxtecan (anti-ERBB3) (Ab183315) is more than 95% verified by HPLC.
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
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| 批号(Lot Number) | 证书类型 | 货号 |
|---|---|---|
 ZJ24F1114109 |
分析证书 | Ab183315 |
| ZJ24F1114110 |
分析证书 | Ab183315 |
| ZJ24F1114111 |
分析证书 | Ab183315 |
| ZJ24F0607557 |
分析证书 | Ab183315 |
| ZJ24F0607558 |
分析证书 | Ab183315 |
| ZJ24F0607559 |
分析证书 | Ab183315 |
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