ExactAb™,低内毒素,已验证,无动物源,无叠氮钠,无载体,重组 级 提供 ≥95%(SDS-PAGE&SEC-HPLC) 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
-80℃储存,避免反复冻融。特低温运输 。请查阅批次 COA 获取详细规格。
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
Dalotuzumab (anti-IGF1R) 是一种靶向 IGF-1R 的重组人源化单克隆抗体 (IgG1 型)。Dalotuzumab (anti-IGF1R) 通过抑制 IGF-1 和 IGF-2 介导的肿瘤细胞增殖、IGF-1R 自体磷酸化和 Akt 磷酸化而发挥作用。Dalotuzumab (anti-IGF1R) 还可诱导细胞凋亡和周期停滞。Dalotuzumab (anti-IGF1R) 与其他抗癌活性分子（如他汀类活性分子）共同使用，可增强 Dalotuzumab (anti-IGF1R) 的体外和体内抗肿瘤活性。
Dalotuzumab (anti-IGF1R) is a recombinant humanized monoclonal antibody (IgG1 type) targeting IGF-1R. Dalotuzumab (anti-IGF1R) acts by inhibiting IGF-1- and IGF-2-mediated tumor cell proliferation, IGF-1R autophosphorylation, and Akt phosphorylation. Dalotuzumab (anti-IGF1R) also induces apoptosis and cycle arrest. Dalotuzumab (anti-IGF1R) in combination with other anticancer agents such as statins can enhance the antitumor activity of Dalotuzumab (anti-IGF1R) in vitro and in vivo.
Dalotuzumab (anti-IGF1R) (Ab183419) - Flow Cytometry
Flow Cytometry analysis of A549 cells labelling IGF1R (red) with Dalotuzumab (anti-IGF1R) (Ab183419). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Dalotuzumab (anti-IGF1R) (Ab183419) - Flow Cytometry
Flow Cytometry analysis of MCF-7 cells labelling IGF1R (red) with Dalotuzumab (anti-IGF1R) (Ab183419). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Dalotuzumab (anti-IGF1R) (Ab183419) - Flow Cytometry
Flow Cytometry analysis of HeLa cells labelling IGF1R (red) with Dalotuzumab (anti-IGF1R) (Ab183419). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Dalotuzumab (anti-IGF1R) (Ab183419) - SEC
The purity of Dalotuzumab (anti-IGF1R) (Ab183419) is more than 95% verified by HPLC.
Dalotuzumab (anti-IGF1R) (Ab183419) - ELISA
Immobilized Recombinant Human AVItag His-IGF1R-Sino protein at 2.0 μg/mL can bind Dalotuzumab (anti-IGF1R) (Ab183419) with the EC50 of 1.09 ng/mL.
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！
| 批号(Lot Number) | 证书类型 | 货号 |
|---|---|---|
 ZJ24F0910555 |
分析证书 | Ab183419 |
| ZJ24F0910556 |
分析证书 | Ab183419 |
| ZJ24F0910557 |
分析证书 | Ab183419 |
我们的级别选择指南涵盖了目录中所有的变体的纯度、稳定剂状态和应用适用性。
查看 Animal Free 级别指南 → 查看 Carrier Free 级别指南 → 查看 Recombinant 级别指南 → 查看 Validated 级别指南 → 查看 ExactAb™ 级别指南 → 查看 Low Endotoxin 级别指南 → 查看 Azide Free 级别指南 →
危险品化学品经营许可证（带存储）