Cyclophilin A Mouse mAb

Name: Cyclophilin A Mouse mAb
SKU: Ab183902
Availability: InStock

货号: Ab183902

COA

有货

级别和纯度: 无动物源 ? 无载体 ? ExactAb™ ? 无叠氮钠 ? 已验证 ? 高性能 ? PBS Only ? ≥95%(SDS-PAGE) 1.0 mg/mL

应用

ELISA, Flow Cytometry, WB

宿主种属

小鼠(Mouse)

种属反应性

人(Human), 大鼠(Rat), 小鼠(Mouse)

亚型

Mouse IgG1

克隆号

EF01/4D12

偶联

Unconjugated

规格

库存

价格

数量

10μl

Ab183902-10μl

现货

¥299.90

50μL

Ab183902-50μl

现货

¥524.90

100μL

Ab183902-100μl

现货

¥749.90

1ml

Ab183902-1ml

现货

¥3,939.90

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概述规格储存与运输图片应用技术文档高级数据关联靶点（人）质检证书（CoA,COO,BSE/TSE 和分析图谱) 技术文档和文章溶液计算器

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为什么选择此级别

ExactAb™,PBS Only,已验证,无动物源,无叠氮钠,无载体,高性能级提供 ≥95%(SDS-PAGE) 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。

🌡

储存与运输

-20°C储存,避免反复冻融。超低温运输。请查阅批次 COA 获取详细规格。

📋

质量文档

SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。

📚

文献证明

在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。

概述

Mouse anti Human Cyclophilin A Antibody, clone EF01/4D12, could be used for WB, Flow Cytometry, ELISA and so on.

规格

产品名称

Cyclophilin A Mouse mAb

别名

英文别名

规格或纯度

无动物源,无载体,ExactAb™,无叠氮钠,已验证,高性能,PBS Only,≥95%(SDS-PAGE),1.0 mg/mL

生化机理

Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation; Activates endothelial cells (ECs) in a pro-inflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM. Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2. Negatively regulates MAP3K5/ASK1 kinase activity, autophosphorylation and oxidative stress-induced apoptosis mediated by MAP3K5/ASK1. Necessary for the assembly of TARDBP in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and regulates TARDBP binding to RNA UG repeats and TARDBP-dependent expression of HDAC6, ATG7 and VCP which are involved in clearance of protein aggregates. Plays an important role in platelet activation and aggregation. Regulates calcium mobilization and integrin ITGA2B:ITGB3 bidirectional signaling via increased ROS production as well as by facilitating the interaction between integrin and the cell cytoskeleton. Binds heparan sulfate glycosaminoglycans. Inhibits replication of influenza A virus (IAV). Inhibits ITCH/AIP4-mediated ubiquitination of matrix protein 1 (M1) of IAV by impairing the interaction of ITCH/AIP4 with M1, followed by the suppression of the nuclear export of M1, and finally reduction of the replication of IAV (Microbial infection) May act as a mediator between human SARS coronavirus nucleoprotein and BSG/CD147 in the process of invasion of host cells by the virus (Microbial infection) Stimulates RNA-binding ability of HCV NS5A in a peptidyl-prolyl cis-trans isomerase activity-dependent manner.

宿主种属

小鼠(Mouse)

特异性

Human Cyclophilin A

种属反应性

人(Human),大鼠(Rat),小鼠(Mouse)

预测反应种属

Chlorocebus aethiops,Macaca mulatta,Pan paniscus,Pan troglodytes,Piliocolobus tephrosceles,Pongo pygmaeus,Pygathrix nigripes,Rhinopithecus roxellana,Symphalangus syndactylus

免疫原

Recombinant protein corresponding to Human Cyclophilin A

阳性对照

WB: HeLa, K562, HepG2, A549, Jurkat, A431and NIH/3T3 whole cell lysates; Mouse brain and Rat brain tissue Flow Cytometry: HeLa cells

偶联

Unconjugated

克隆类型

单克隆抗体

Format

Whole IgG

轻链亚型

kappa

纯化方法

Protein A purified

浓度

1.0 mg/mL

分子类型

抗体

产品线

生物产品

储存与运输

储存缓冲液

PBS, pH 7.2

储存条件

-20°C储存,避免反复冻融

运输条件

超低温运输

稳定性与储存

Store at 4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.

图片

Western Blot: Cyclophilin A Mouse mAb (Ab183902)

Cyclophilin A Mouse mAb (Ab183902) - Western Blot
All lanes: Cyclophilin A Mouse Antibody (Ab183902) at 1/10000 dilution
Samples: Lysates at 20 µg per lane
Secondary: Goat Anti-Mouse IgG H&L (HRP) (Ab179001) at 1/20000 dilution
Predicted band size: 18 kDa
Observed band size: 17 kDa
Exposure time: 60.0 s

Western Blot: Cyclophilin A Mouse mAb (Ab183902)

Flow Cytometry: Cyclophilin A Mouse mAb (Ab183902)

Cyclophilin A Mouse mAb (Ab183902) - Flow Cytometry
Flow Cytometry analysis of HeLa cells stained with Cyclophilin A Mouse mAb (Ab183902) (Red) at 5 μg/mL for 1 hour at 4°C. Cells were fixed and permeabilized with 100% methanol. The Goat Anti-Mouse IgG H&L (PE) (Ab179006) was used as the secondary antibody. Unlabeled sample (Black) was used as a negative control. Mouse IgG1-kappa, anti-E8L (Ab213557) was used as an isotype control (Blue).

应用

应用名称

稀释比例

1/1000 - 1/20000

Flow Cytometry

1/200 - 1/3000

技术文档

📋 安全数据表 (SDS)

全面的危险、操作、储存及法规合规文件。

下载 SDS →

✅ 分析证书 (COA)

批次质量数据。输入批号以获取对应 COA。

查询 COA →

📊 产品数据表

产品规格和应用的快速参考摘要。

查看数据表 →

🔬 规格说明书

该级别的完整质量属性和验收标准。

查看规格说明 →

高级数据

关联靶点（人）

PPIA Tclin 肽基脯氨酰顺反异构酶A(Peptidyl-prolyl cis-trans isomerase A) (0 活性数据)

点击查看靶蛋白信息： PPIA

活性类型	活性值-log(M)	作用机制	期刊	参考文献(PubMed IDs)

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

输入批号以搜索分析图谱:

通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

找到7个结果

批号(Lot Number)	证书类型	货号
ZJ26F0838552	分析证书	Ab183902
ZJ26F0838551	分析证书	Ab183902
ZJ26F0838550	分析证书	Ab183902
ZJ26F0838549	分析证书	Ab183902
ZJ25F0319960	分析证书	Ab183902
ZJ25F0319959	分析证书	Ab183902
ZJ25F0319958	分析证书	Ab183902

技术文档和文章

内参抗体的类型、选择原则与实验应用

目录：技术文章

探索主题:

内参抗体 Loading control 多重检测参考蛋白蛋白归一化亚细胞分馏

Types, Selection Principles, and Experimental Applications of Loading Control Antibodies

目录：技术文章

探索主题:

Loading control Subcellular Fractionation Multiplex detection loading control antibodies reference proteins protein normalization

溶液计算器

摩尔浓度计算器

计算溶液所需的质量、体积或浓度。

质量

浓度

体积

分子量

g/mol

稀释计算器

计算配制储备溶液所需的稀释度。

浓度1（C1）

体积 1 (V1)

浓度 2 (C2)

体积 2 (V2)

复溶计算器

复溶计算器允许您快速计算试剂的体积，以复溶小瓶。只需输入试剂的质量和目标浓度，计算器将确定其余部分。

体积（添加到小瓶中）

质量（小瓶）

所需的复溶浓度

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Cyclophilin A Mouse mAb

储存与运输

质量文档

文献证明

概述

规格

技术文档

📋 安全数据表 (SDS)

✅ 分析证书 (COA)

📊 产品数据表

🔬 规格说明书

高级数据

摩尔浓度计算器

稀释计算器

复溶计算器

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