ExactAb™,低内毒素,已验证,无动物源,无叠氮钠,无载体,重组 级 提供 ≥95%(SDS-PAGE&SEC-HPLC) 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
-80℃储存,避免反复冻融。特低温运输 。请查阅批次 COA 获取详细规格。
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在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
XmAb 5592 (anti-BST2) 是一种人源化 Fc 工程抗 HM1.24 抗体，增强了与 FcγRIIIa 和 FcγRIIIa 受体的结合，通过抗体依赖的细胞细胞毒作用 (ADCC) 和抗体依赖的细胞吞噬作用 (ADCP) 增强 HM1.24 特异性多发性骨髓瘤 (MM) 细胞的体外裂解。
XmAb 5592 (anti-BST2) is a humanized, Fc-engineered anti-HM1.24 antibody with enhanced binding to FcγRIIIa and FcγRIIa receptors, augments HM1.24-specific multiple myeloma (MM) cells lysis in vitro via antibody-dependent cellular cytotoxicity (ADCC) and antibody dependent cellular phagocytosis (ADCP).
Purity
≥95% (SDS-PAGE&SEC)
Endotoxin Level
≤1.0EU/mg
Protein Function
May be involved in the sorting of secreted proteins (By similarity). May be involved in pre-B-cell growth. Antiretroviral defense protein, that blocks release of retrovirus from the cell surface. Depleted unpon HIV-1 infection by viral VPU protein through 20S proteasome degradation. Depleted upon infection by human Kaposi's sarcoma-associated herpesvirus (KSHV) through ubiquitination and subsequent degradation. May play a role in B-cell activation in rheumatoid arthritis.
XmAb 5592 (anti-BST2) (Ab190137) - Flow Cytometry
Flow Cytometry analysis of HeLa cells labelling BST2 (red) with XmAb 5592 (anti-BST2) (Ab190137). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
XmAb 5592 (anti-BST2) (Ab190137) - SEC
The purity of XmAb 5592 (anti-BST2) (Ab190137) is more than 95% verified by HPLC.
XmAb 5592 (anti-BST2) (Ab190137) - ELISA
Immobilized Recombinant Human BST2/Tetherin protein (rp183660) at 1.0 μg/mL can bind XmAb 5592 (anti-BST2) (Ab190137) with the EC
₅₀
of 18.08 ng/mL.
XmAb 5592 (anti-BST2) (Ab190137) - Flow Cytometry
Flow Cytometry analysis of Jurkat cells labelling BST2 (red) with XmAb 5592 (anti-BST2) (Ab190137). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
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| 批号(Lot Number) | 证书类型 | 货号 |
|---|---|---|
 ZJ24F0910150 |
分析证书 | Ab190137 |
| ZJ24F0910151 |
分析证书 | Ab190137 |
| ZJ24F0910152 |
分析证书 | Ab190137 |
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