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Oportuzumab (anti-EpCAM)
货号:
Ab190146
级别和纯度:
无动物源 ?
无动物源(Animal Free)—— 不含动物源成分生产,降低污染风险。适用于避免动物源材料的生物制造和培养。
无载体 ?
无载体(Carrier Free)—— 不含添加的载体蛋白/稳定剂。当载体(如 BSA)会干扰偶联或敏感检测时使用。
重组 ?
重组(Recombinant)—— 通过重组表达生产,序列确定、批次稳定。适用于来源明确、无动物源的可重现蛋白。
ExactAb™ ?
ExactAb™ —— 阿拉丁强调精准和验证质量的抗体系列。适用于可靠、特异性经验证的抗体应用。
低内毒素 ?
低内毒素级 —— 内毒素降至受控低水平。适用于高内毒素会造成干扰的敏感生物工作。
无叠氮钠 ?
无叠氮(Azide Free)—— 不含叠氮化钠防腐剂。适用于叠氮有毒或有抑制作用的偶联、细胞工作或检测。
已验证 ?
已验证级 —— 发布前在特定应用中确认性能。当需要试剂按声称工作的书面保证时使用。
≥95%(SDS-PAGE&SEC-HPLC)
见COA
应用
Animal Model, ELISA, Flow Cytometry, Functional Assay
种属反应性
人(Human), 小鼠(Mouse)
概述
Oportuzumab (anti-EpCAM) 是一种针对 EpCAM 的人源化单克隆抗体。它在治疗卡介苗难治性膀胱原位癌方面具有潜力。
Oportuzumab (anti-EpCAM) is a humanized monoclonal antibody targeting EpCAM. It exhibits potential in treatment of bacillus Calmette-Guérin refractory carcinoma in situ of the bladder.
规格
产品名称
Oportuzumab (anti-EpCAM)
英文别名
17 1A antibody|323/A3 antibody|Adenocarcinoma associated antigen antibody|Adenocarcinoma-associated antigen antibody|Antigen identified by monoclonal antibody AUA1 antibody|AUA1 antibody|CD326 antibody|CD326 antigen antibody|Cell surface glycoprotein Trop 1 antibody|Cell surface glycoprotein Trop 2 antibody|Cell surface glycoprotein Trop-1 antibody|CO 17A antibody|CO17 1A antibody|CO17A antibody|DIAR5 antibody|EGP 2 antibody|EGP antibody|EGP2 antibody|EGP314 antibody|EGP40 antibody|Ep CAM antibody|Ep-CAM antibody|EPCAM antibody|EpCAM1 antibody|Epithelial cell adhesion molecule antibody|Epithelial Cell Adhesion Molecule Intracellular Domain (EpCAM-ICD) antibody|Epithelial cell surface antigen antibody|Epithelial cellular adhesion molecule antibody|Epithelial glycoprotein 1 antibody|Epithelial glycoprotein 314 antibody|Epithelial glycoprotein antibody|ESA antibody|GA733 1 antibody|GA733 2 antibody|GA733-2 antibody|gastrointestinal tumor-associated antigen 2, 35-KD glycoprotein antibody|gp4 antibody|hEGP 2 antibody|hEGP314 antibody|HNPCC8 antibody|Human epithelial glycoprotein 2 antibody|KS 1/4 antigen antibody|KS1/4 antibody|KSA antibody|Ly74 antibody|Lymphocyte antigen 74 antibody|M1S 1 antibody|M1S2 antibody|M4S1 antibody|Major gastrointestinal tumor associated protein GA733 2 antibody|Major gastrointestinal tumor-associated protein GA733-2 antibody|mEGP314 antibody|Membrane component chromosome 4 surface marker (35kD glycoprotein) antibody|Membrane component, chromosome 4, surface marker 1 antibody|Membrane component, chromosome 4, surface marker antibody|MIC18 antibody|MK 1 antibody|Protein 289A antibody|TACD1 antibody|TACSTD1 antibody|TROP1 antibody|Tumor associated calcium signal transducer 1 antibody|Tumor associated calcium signal transducer 2 precursor antibody|Tumor-associated calcium signal transducer 1 antibody|ACSTD1|antigen identified by monoclonal AUA1|CD326 antigen|CD326|Cell surface glycoprotein Trop-1|chromosome 4, surface marker (35kD glycoprotein)|DIAR5|EGP|EGP-2|EGP314|EGP40|EpCAM|epithelial cell adhesion molecule|Epithelial cell surface antigen|Epithelial glycoprotein 314|Epithelial glycoprotein|ESA|gp40|hEGP314|HNPCC8|KS 1/4 antigen|KSAHEA125|Major gastrointestinal tumor-associated protein GA733-2|MIC18MH99|MOC31|TACST-1|TACSTD1|TROP1|Tumor-associated calcium signal transducer 1CO-17A
规格或纯度
无载体, 重组, ExactAb™, 低内毒素, 无叠氮钠, 已验证, 无动物源, ≥95%(SDS-PAGE&SEC-HPLC), 见COA
生化机理
May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E.
Post-translational: Hyperglycosylated in carcinoma tissue as compared with autologous normal epithelia. Glycosylation at Asn-198 is crucial for protein stability.
储存与运输
储存缓冲液
Supplied as a 0.22μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
稳定性与储存
在 -80℃ 下保存 24 个月。收货后建议分装。避免冷冻/解冻循环。
图片
Flow Cytometry: Oportuzumab (anti-EpCAM) (Ab190146)
Oportuzumab (anti-EpCAM) (Ab190146) - Flow Cytometry Flow Cytometry analysis of MCF7 cells labelling EpCAM (red) with Oportuzumab (anti-EpCAM) (Ab190146 ) at 1.0 μg/mL for 1 hour at 4°C. Goat Anti-Human IgG (PE) (Ab175838 ) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213 ). Black - Unlabelled control, cells without incubation with primary antibody.
SEC: Oportuzumab (anti-EpCAM) (Ab190146)
Oportuzumab (anti-EpCAM) (Ab190146) - SEC The purity of Oportuzumab (anti-EpCAM) (Ab190146 ) is more than 95% verified by HPLC.
ELISA: Oportuzumab (anti-EpCAM) (Ab190146)
Oportuzumab (anti-EpCAM) (Ab190146) - ELISA Immobilized Recombinant Human EpCAM protein (rp170132) at 1.0 μg/mL can bind Oportuzumab (anti-EpCAM) (Ab190146 ) with the EC₅₀ of 39.05 ng/mL.
高级数据
关联靶点(人)
作用机制
作用机制
Action Type
target ID
Target Name
Target Type
Target Organism
Binding Site Name
参考文献
质检证书(CoA,COO,BSE/TSE 和分析图谱)
溶液计算器
常见问题
什么是「无动物源」?
「无动物源」表示该物料经过加工和检测,适用于特种工业加工。规格侧重于影响该应用性能的杂质——例如,电子应用的金属含量、电池应用的粒度、光学应用的折射率,或对水分敏感工艺的水分含量。
什么是「无载体」?
「无载体」表示该物料经过加工和检测,适用于特种工业加工。规格侧重于影响该应用性能的杂质——例如,电子应用的金属含量、电池应用的粒度、光学应用的折射率,或对水分敏感工艺的水分含量。
本产品应如何储存?
请于?80 °C条件下保存。避免反复冻融。建议按单次用量分装保存。
本产品如何运输?
本产品采用干冰配冷袋冷冻运输。收货后请立即拆包,并按上述储存条件保存;处理干冰时请戴隔热手套并保持通风。
如何获取批次专用COA?
每个订单都会随附分析证书(COA),您也可以从账户订单历史中下载。如需订购前的COA,请联系您的客户代表,或使用PDP上的"申请COA"按钮——我们将提供代表性批次的COA。
该抗体已验证对哪些物种有反应性?
已验证的反应性列在PDP和每批次的数据表上。我们针对靶标(Oportuzumab (anti-EpCAM))最常测试的物种进行验证;未经测试的物种可能存在交叉反应性,但不能保证。如有特定物种咨询,请联系技术支持。
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