Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions.
Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes.
Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions.
Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils.
Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal.
Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells; PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes.
Modulates bradykinin receptor BDKRB2 activation.
Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in endothelial cells.
Induces susceptibility to atherosclerosis (By similarity).
宿主种属
小鼠(Mouse)
特异性
Human CD31
种属反应性
人(Human)
免疫原
Recombinant protein corresponding to Human CD31
阳性对照
WB: HUVEC, THP-1 and Jurkat whole cell lysates
偶联
Unconjugated
克隆类型
单克隆抗体
Format
Whole IgG
轻链亚型
kappa
纯化方法
Protein A purified
浓度
0.5 mg/mL
分子类型
抗体
产品线
生物产品
储存与运输
储存缓冲液
PBS, pH 7.2
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
Store at 4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
图片
CD31 Mouse mAb (Ab216301) - Western Blot All lanes: CD31 Mouse Antibody (Ab216301) at 1/500 dilution Samples: Lysates at 20 µg per lane Secondary: Goat Anti-Mouse IgG H&L (HRP) (Ab179001) at 1/20000 dilution Predicted band size: 82 kDa Observed band size: 126 kDa Exposure time: 60.0 s
ZJ25F0319323
危险品化学品经营许可证（带存储）