Induces susceptibility to atherosclerosis (By similarity). Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Prevents phagocyte ingestion of closely apposed viable cells by transmitting 'detachment' signals, and changes function on apoptosis, promoting tethering of dying cells to phagocytes (the encounter of a viable cell with a phagocyte via the homophilic interaction of PECAM1 on both cell surfaces leads to the viable cell's active repulsion from the phagocyte. During apoptosis, the inside-out signaling of PECAM1 is somehow disabled so that the apoptotic cell does not actively reject the phagocyte anymore. The lack of this repulsion signal together with the interaction of the eat-me signals and their respective receptors causes the attachment of the apoptotic cell to the phagocyte, thus triggering the process of engulfment). Isoform Delta15 is unable to protect against apoptosis. Modulates BDKRB2 activation. Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in human umbilical cord vein cells (HUVEC).
宿主种属
兔(Rabbit)
特异性
PECAM1
种属反应性
人(Human)
免疫原
A synthetic peptide derived from human CD31(AA 150-200)
阳性对照
WB: Jurkat and HUVEC cell lysates. IHC: Human kidney tissue.
Recombinant CD31 Antibody (Ab094534) - Western Blot All lanes: Recombinant CD31 Antibody (Ab094534) at 1/1000 dilution Samples: Lysates at 20 µg per lane Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution Predicted band size: 83 kDa Observed band size: 118 kDa Exposure time: 89.0 s
Recombinant CD31 Antibody (Ab094534) - IHC Immunohistochemical analysis of paraffin-embedded human kidney using Recombinant CD31 Antibody (Ab094534). High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.
ZJ24F0910087
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