Rabbit anti Human GSK3 beta Antibody, Recombinant, could be used for WB, IHC and so on.
规格
产品名称
Recombinant GSK3 beta Antibody
规格或纯度
重组,ExactAb™,已验证,高性能,PBS Only,见COA
生化机理
Participates in the Wnt signaling pathway. Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates MUC1 in breast cancer cells, and decreases the interaction of MUC1 with CTNNB1/beta-catenin. Phosphorylates CTNNB1/beta-catenin. Phosphorylates SNAI1. Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. Prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Phosphorylates MACF1 and this phosphorylation inhibits the binding of MACF1 to microtubules which is critical for its role in bulge stem cell migration and skin wound repair.
宿主种属
兔(Rabbit)
特异性
GSK3 beta
种属反应性
人(Human),仓鼠(Hamster),大鼠(Rat),小鼠(Mouse)
免疫原
A synthetic peptide derived from human GSK3 beta (AA 1-13)
阳性对照
WB: Jurkat, HeLa, HEK293, A431, NIH/3T3 and C6 cell lysates. IHC: Human cholangiocarcinoma. IF/ICC: HeLa cells.