Rabbit anti Human MEF2A Antibody, Recombinant, could be used for WB, IF/ICC and so on. Application: WB: 1/500-1/2000 IF/ ICC: 1/50-1/200 Protein Function: Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation.
规格
产品名称
Recombinant MEF2A Antibody
规格或纯度
重组, ExactAb™, 已验证, PBS Only, 无载体, 无叠氮钠, 见COA
生化机理
Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation.
宿主种属
兔(Rabbit)
特异性
MEF2A
种属反应性
人(Human),大鼠(Rat),小鼠(Mouse)
免疫原
A synthetic peptide derived from human MEF2A (AA 471-489)
阳性对照
WB: Mouse brain lysates. IF/ICC: MCF-7, HeLa cells.