基本描述

别名	刀豆素A
英文别名	Concanavalin A
规格或纯度	≥90%
英文名称	Concanavalin A lectin (Con A)
生化机理	刀豆素 A 无血型特异性，但对末端 α-D-甘露糖基和 α-D-葡糖基残基具有亲和力。需要 Ca2+ 和 Mn2+ 离子存在才能显示活性。在 pH 6.5 或更低的条件下解离为二聚体,在 pH 5.8 至 7.0 之间时，以四聚体形式存在,pH 高于 7.0 时，形成更高的聚合体。根据聚合程度不同，可能显示出具有促有丝分裂的活性。琥珀酰化可以生成一?种能够在 pH 高于 5.6 时仍保持二聚体形式的活性二聚体。
储存温度	-20°C储存
运输条件	超低温冰袋运输
产品介绍	Concanavalin A (Con A) lectin is isolated from Jack beans (Canavalia ensiformis) and purified by affinity chromatography. The molecular weight of the lectin is 104 kDa. It has broad applicability and is the most widely used lectin within molecular biology research. Con A binds specifically to α-Mannose, α-Galactose structures found in sugars, glycoproteins and glycolipids . The lectin has been utilized in hormone receptor studies, mitogenic assays and for characterizing normal and malignant cells (cancer cells are readily aggregated by Con A while normal cells are not). Con A can also initiate cell division (mitogenesis) principally acting on T-lymphocytes . Immobilized Con A has been used in affinity chromatography purifications of a wide variety of glycoproteins and cellular structures. Polyacrylamide gel electrophoresis in SDS of Con A from Jack beans yields three major bands corresponding to molecular weights 27, 13 and 10 kDa. One minor band is visible at 18 kDa. Medicago’s Con A is supplied as a white lyophilized powder from a buffer containing 0.5 mM MnCl2, 0.5 mM CaCl2, no preservatives are added. The identity is determined by SDS-PAGE (Figure 1) and the protein content by spectrophotometry (Figure 2). The lectin is available in vials containing 250 mg or 100 mg lyophilized powder and the product is to be used for laboratory work only.

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名称和识别符

EC号	234-258-2
IUPAC Name	1-[4-azido-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione;4-(dipropylsulfamoyl)benzoic acid
INCHI	InChI=1S/C13H19NO4S.C10H13N5O4/c1-3-9-14(10-4-2)19(17,18)12-7-5-11(6-8-12)13(15)16;1-5-3-15(10(18)12-9(5)17)8-2-6(13-14-11)7(4-16)19-8/h5-8H,3-4,9-10H2,1-2H3,(H,15,16);3,6-8,16H,2,4H2,1H3,(H,12,17,18)
InChi Key	RVSZVJZFCQZYHQ-UHFFFAOYSA-N
Canonical SMILES	CCCN(CCC)S(=O)(=O)C1=CC=C(C=C1)C(=O)O.CC1=CN(C(=O)NC1=O)C2CC(C(O2)CO)N=[N+]=[N-]
Isomeric SMILES	CCCN(CCC)S(=O)(=O)C1=CC=C(C=C1)C(=O)O.CC1=CN(C(=O)NC1=O)C2CC(C(O2)CO)N=[N+]=[N-]
WGK Germany	3
RTECS	GK6890000
PubChem CID	155486958

化学和物理性质

溶解性	溶于水（轻微浑浊）和 PBS（5 mg/mL，轻微浑浊）
敏感性	对湿度敏感
分子量	552.600 g/mol
XLogP3
氢键供体数Hydrogen Bond Donor Count	3
氢键受体数Hydrogen Bond Acceptor Count	11
可旋转键计数Rotatable Bond Count	10
精确质量Exact Mass	552.2 Da
单同位素质量Monoisotopic Mass	552.2 Da
拓扑极表面积Topological Polar Surface Area	176.000 Å²
重原子数Heavy Atom Count	38
形式电荷Formal Charge	0
复杂度Complexity	858.000
同位素原子数Isotope Atom Count	0
定义的原子立体中心计数Defined Atom Stereocenter Count	0
未定义的原子立体中心计数Undefined Atom Stereocenter Count	3
定义的键立体中心计数Defined Bond Stereocenter Count	0
未定义的键立体中心计数Undefined Bond Stereocenter Count	0
所有立体化学键的总数The total count of all stereochemical bonds	0
共价键合单元计数Covalently-Bonded Unit Count	2

安全和危险性（GHS）

象形图	GHS08, GHS07
信号词	Danger
危险声明	H317: 可能引起皮肤过敏反应 H334: 吸入可能引起过敏或哮喘病症状或呼吸困难 H361: 怀疑破坏生育力或未出生的孩子
预防措施声明	P261: 避免吸入灰尘/烟雾/气体/雾/蒸汽/喷雾 P280: 戴防护手套/穿防护服/戴防护眼罩/戴防护面具。 P302+P352: 如皮肤沾染：用水充分清洗。 P321: 特殊处理（请参阅此标签上的...）。 P405: 密闭存放 P501: 将内容物/容器处理到。。。 P284: 如果通风不良，请佩戴呼吸防护装置。 P304+P340: 如误吸入：将人转移到空气新鲜处，保持呼吸舒适体位。 P272: 被污染的工作服不允许离开工作场所 P333+P313: 如发生皮肤刺激或皮疹：求医/就诊。 P362+P364: 脱掉沾污的衣服，清洗后方可重新使用。 P203: 使用前，获取、阅读并遵守所有安全说明。 P318: 如果暴露或担心，请就医。 P342+P316: 如果出现呼吸道症状：立即寻求急救。
WGK Germany	3
RTECS	GK6890000
个人防护装备	dust mask type N95 (US),Eyeshields,Faceshields,Gloves

质检证书（CoA,COO,BSE/TSE 和分析图谱)

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找到19个结果

批号(Lot Number)	证书类型	日期	货号
H2405523	分析证书	24-07-24	C491285
H2405518	分析证书	24-07-24	C491285
H2405517	分析证书	24-07-24	C491285
H2405516	分析证书	24-07-24	C491285
D2425153	分析证书	24-04-12	C491285
D2425155	分析证书	24-04-12	C491285
D2425157	分析证书	24-04-12	C491285
D2425159	分析证书	24-04-12	C491285
D2425281	分析证书	24-04-12	C491285
D2425282	分析证书	24-04-12	C491285
D2425283	分析证书	24-04-12	C491285
B2317545	分析证书	23-02-23	C491285
J2326075	分析证书	22-08-31	C491285
H2223243	分析证书	22-08-31	C491285
H2223242	分析证书	22-08-31	C491285
H2223241	分析证书	22-08-31	C491285
H2223240	分析证书	22-08-31	C491285
G2319036	分析证书	22-08-31	C491285
E2311180	分析证书	22-08-31	C491285

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此产品的引用文献

如何在您的发表作品中引用阿拉丁的产品和网站?

1. Ya Li, Yao Lu, Yang Chen, Pei Zhang, Nengqin Jia. (2023) Fullerene-promoted organic-inorganic hybrid electrochemiluminescence biosensor for sensitive detection of concanavalin A. SENSORS AND ACTUATORS B-CHEMICAL, 393 (134311). [10.1016/j.snb.2023.134311]
2. Tongtong Zhang, Shuai Xu, Xingyu Lin, Jiyang Liu, Kai Wang. (2023) Label-Free Electrochemical Aptasensor Based on the Vertically-Aligned Mesoporous Silica Films for Determination of Aflatoxin B1. Biosensors-Basel, 13 (6): (661). [PMID:37367026] [10.3390/bios13060661]
3. Jinxia ZHU, Hongxiu CHEN, Jianjiao CUI, Xiaorui ZHANG, Guangwei LIU. (2023) Oroxylin A inhibited autoimmune hepatitis-induced liver injury and shifted Treg/Th17 balance to Treg differentiation. EXPERIMENTAL ANIMALS, [PMID:36927981] [10.1538/expanim.22-0171]
4. Zhengge Wang, Chengyu Fu, Yingtao Gao, Zhaoji Wu, Weiqing Chen, Bowen Hu, Siqi Xu, Zhigang Zhang, Peng Yang. (2023) Dual functional antifouling and bactericidal proteinaceous coating. COLLOIDS AND SURFACES B-BIOINTERFACES, 225 (113239). [PMID:36889106] [10.1016/j.colsurfb.2023.113239]
5. Yufang Li, Shu Wang, Haojie Ding, Kang Xiao, Xia Huang. (2023) Quorum sensing-Fe metabolism interplay affects biofouling on reverse osmosis membrane: Evidences from microbial shift and structure alteration. DESALINATION, 551 (116416). [10.1016/j.desal.2023.116416]
6. Haoran Jiang, Xianxin Wen, Xue Zhang, Bingyu Zhang. (2022) Concanavalin A inhibits human liver cancer cell migration by regulating F‑actin redistribution and assembly via MAPK signaling pathway. Oncology Letters, 24 (5): (1-12). [PMID:36276493] [10.3892/ol.2022.13525]
7. Zhaoquan Zheng, Bingyu Wang, Jing Chen, Yan Wang, Ziyue Miao, Cenyao Shang, Qiang Zhang. (2021) Facile synthesis of Antibacterial, Biocompatible, quaternized Poly(ionic liquid)s with pendant saccharides. EUROPEAN POLYMER JOURNAL, 158 (110702). [10.1016/j.eurpolymj.2021.110702]
8. Die Li, Jing Chen, Mei Hong, Yan Wang, David M. Haddleton, Guang-Zhao Li, Qiang Zhang. (2021) Cationic Glycopolymers with Aggregation-Induced Emission for the Killing, Imaging, and Detection of Bacteria. BIOMACROMOLECULES, 22 (5): (2224–2232). [PMID:33909978] [10.1021/acs.biomac.1c00298]
9. Xiu-yan Li, Pin Peng, Wei-kang Wang, Si-yuan Wang, Lei Feng, Yan-chen Zhang, Juan Xu. (2021) Particle electrode materials dependent tetrabromobisphenol A degradation in three-dimensional biofilm electrode reactors. ENVIRONMENTAL RESEARCH, 197 (111089). [PMID:33811867] [10.1016/j.envres.2021.111089]
10. Xia Wang, Jianbo Zhu, Baida Kong, Bingnan He, Lai Wei, Yuanxiang Jin, Yudong Shan, Weitao Wang, Chunqiang Pan, Zhengwei Fu. (2019) C9–13 chlorinated paraffins cause immunomodulatory effects in adult C57BL/6 mice. SCIENCE OF THE TOTAL ENVIRONMENT, 675 (110). [PMID:31026635] [10.1016/j.scitotenv.2019.04.199]
11. Pang Juan, Gao Ziyu, Tan Huaping, Mao Xincheng, Wang Huiming, Hu Xiaohong. (2019) Design, Synthesis, Investigation, and Application of a Macromolecule Photoswitch. Frontiers in Chemistry, 7 [PMID:30873401] [10.3389/fchem.2019.00086]
12. Jianwen Hou, Runhai Chen, Jingchuan Liu, Haozheng Wang, Qiang Shi, Zhirong Xin, Shing-Chung Wong, Jinghua Yin. (2018) Multiple microarrays of non-adherent cells on a single 3D stimuli-responsive binary polymer-brush pattern. Journal of Materials Chemistry B, 6 (29): (4792-4798). [PMID:32254306] [10.1039/C8TB01441H]
13. Xiaojian Li, Yaoguang Wang, Li Shi, Hongmin Ma, Yong Zhang, Bin Du, Dan Wu, Qin Wei. (2017) A novel ECL biosensor for the detection of concanavalin A based on glucose functionalized NiCo2S4 nanoparticles-grown on carboxylic graphene as quenching probe. BIOSENSORS & BIOELECTRONICS, 96 (113). [PMID:28475956] [10.1016/j.bios.2017.04.050]
14. Lu Mengdi, Liang Yuzhang, Qian Siyu, Li Lixia, Jing Zhenguo, Masson Jean-Francois, Peng Wei. (2017) Optimization of Surface Plasmon Resonance Biosensor with Ag/Au Multilayer Structure and Fiber-Optic Miniaturization. Plasmonics, 12 (3): (663-673). [10.1007/s11468-016-0312-4]
15. Shenguang Ge, Lina Zhang, Yan Zhang, Haiyun Liu, Jiadong Huang, Mei Yan, Jinghua Yu. (2015) Electrochemical K-562 cells sensor based on origami paper device for point-of-care testing. TALANTA, 145 (12). [PMID:26459438] [10.1016/j.talanta.2015.05.008]

参考文献

1. Ya Li, Yao Lu, Yang Chen, Pei Zhang, Nengqin Jia. (2023) Fullerene-promoted organic-inorganic hybrid electrochemiluminescence biosensor for sensitive detection of concanavalin A. SENSORS AND ACTUATORS B-CHEMICAL, 393 (134311). [10.1016/j.snb.2023.134311]
2. Tongtong Zhang, Shuai Xu, Xingyu Lin, Jiyang Liu, Kai Wang. (2023) Label-Free Electrochemical Aptasensor Based on the Vertically-Aligned Mesoporous Silica Films for Determination of Aflatoxin B1. Biosensors-Basel, 13 (6): (661). [PMID:37367026] [10.3390/bios13060661]
3. Jinxia ZHU, Hongxiu CHEN, Jianjiao CUI, Xiaorui ZHANG, Guangwei LIU. (2023) Oroxylin A inhibited autoimmune hepatitis-induced liver injury and shifted Treg/Th17 balance to Treg differentiation. EXPERIMENTAL ANIMALS, [PMID:36927981] [10.1538/expanim.22-0171]
4. Zhengge Wang, Chengyu Fu, Yingtao Gao, Zhaoji Wu, Weiqing Chen, Bowen Hu, Siqi Xu, Zhigang Zhang, Peng Yang. (2023) Dual functional antifouling and bactericidal proteinaceous coating. COLLOIDS AND SURFACES B-BIOINTERFACES, 225 (113239). [PMID:36889106] [10.1016/j.colsurfb.2023.113239]
5. Yufang Li, Shu Wang, Haojie Ding, Kang Xiao, Xia Huang. (2023) Quorum sensing-Fe metabolism interplay affects biofouling on reverse osmosis membrane: Evidences from microbial shift and structure alteration. DESALINATION, 551 (116416). [10.1016/j.desal.2023.116416]
6. Haoran Jiang, Xianxin Wen, Xue Zhang, Bingyu Zhang. (2022) Concanavalin A inhibits human liver cancer cell migration by regulating F‑actin redistribution and assembly via MAPK signaling pathway. Oncology Letters, 24 (5): (1-12). [PMID:36276493] [10.3892/ol.2022.13525]
7. Zhaoquan Zheng, Bingyu Wang, Jing Chen, Yan Wang, Ziyue Miao, Cenyao Shang, Qiang Zhang. (2021) Facile synthesis of Antibacterial, Biocompatible, quaternized Poly(ionic liquid)s with pendant saccharides. EUROPEAN POLYMER JOURNAL, 158 (110702). [10.1016/j.eurpolymj.2021.110702]
8. Die Li, Jing Chen, Mei Hong, Yan Wang, David M. Haddleton, Guang-Zhao Li, Qiang Zhang. (2021) Cationic Glycopolymers with Aggregation-Induced Emission for the Killing, Imaging, and Detection of Bacteria. BIOMACROMOLECULES, 22 (5): (2224–2232). [PMID:33909978] [10.1021/acs.biomac.1c00298]
9. Xiu-yan Li, Pin Peng, Wei-kang Wang, Si-yuan Wang, Lei Feng, Yan-chen Zhang, Juan Xu. (2021) Particle electrode materials dependent tetrabromobisphenol A degradation in three-dimensional biofilm electrode reactors. ENVIRONMENTAL RESEARCH, 197 (111089). [PMID:33811867] [10.1016/j.envres.2021.111089]
10. Xia Wang, Jianbo Zhu, Baida Kong, Bingnan He, Lai Wei, Yuanxiang Jin, Yudong Shan, Weitao Wang, Chunqiang Pan, Zhengwei Fu. (2019) C9–13 chlorinated paraffins cause immunomodulatory effects in adult C57BL/6 mice. SCIENCE OF THE TOTAL ENVIRONMENT, 675 (110). [PMID:31026635] [10.1016/j.scitotenv.2019.04.199]
11. Pang Juan, Gao Ziyu, Tan Huaping, Mao Xincheng, Wang Huiming, Hu Xiaohong. (2019) Design, Synthesis, Investigation, and Application of a Macromolecule Photoswitch. Frontiers in Chemistry, 7 [PMID:30873401] [10.3389/fchem.2019.00086]
12. Jianwen Hou, Runhai Chen, Jingchuan Liu, Haozheng Wang, Qiang Shi, Zhirong Xin, Shing-Chung Wong, Jinghua Yin. (2018) Multiple microarrays of non-adherent cells on a single 3D stimuli-responsive binary polymer-brush pattern. Journal of Materials Chemistry B, 6 (29): (4792-4798). [PMID:32254306] [10.1039/C8TB01441H]
13. Xiaojian Li, Yaoguang Wang, Li Shi, Hongmin Ma, Yong Zhang, Bin Du, Dan Wu, Qin Wei. (2017) A novel ECL biosensor for the detection of concanavalin A based on glucose functionalized NiCo2S4 nanoparticles-grown on carboxylic graphene as quenching probe. BIOSENSORS & BIOELECTRONICS, 96 (113). [PMID:28475956] [10.1016/j.bios.2017.04.050]
14. Lu Mengdi, Liang Yuzhang, Qian Siyu, Li Lixia, Jing Zhenguo, Masson Jean-Francois, Peng Wei. (2017) Optimization of Surface Plasmon Resonance Biosensor with Ag/Au Multilayer Structure and Fiber-Optic Miniaturization. Plasmonics, 12 (3): (663-673). [10.1007/s11468-016-0312-4]
15. Shenguang Ge, Lina Zhang, Yan Zhang, Haiyun Liu, Jiadong Huang, Mei Yan, Jinghua Yu. (2015) Electrochemical K-562 cells sensor based on origami paper device for point-of-care testing. TALANTA, 145 (12). [PMID:26459438] [10.1016/j.talanta.2015.05.008]

溶液计算器

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计算溶液所需的质量、体积或浓度。

质量

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分子量

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计算配制储备溶液所需的稀释度。

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所需的复溶浓度

货号 (SKU)	包装规格	是否现货
C491285-25mg	25mg	现货
C491285-100mg	100mg	现货
C491285-250mg	250mg	现货
C491285-1g	1g	现货

刀豆凝集素A(Con A)

库存信息

库存信息

库存信息

库存信息

基本描述

AI解读

名称和识别符

化学和物理性质

安全和危险性（GHS）

质检证书（CoA,COO,BSE/TSE 和分析图谱)

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溶液计算器

摩尔浓度计算器

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