Serotonin (5-hydroxytryptamine, 5HT) has a typical tryptamine structure: an ethylamine side chain is attached at the C3 position of the indole ring, and a hydroxyl group is present at C5. The antimigraine drug sumatriptan retains this indole–ethylamine scaffold while extending the C5 position ...
Depression involves multilevel abnormalities in monoaminergic transmission, the balance between glutamate and GABA, regulation of the stress axis, and synaptic plasticity. Different targets separately influence mood, reward, cognition, sleep, and stress responses and together form an ...