计算溶液所需的质量、体积或浓度。
| 活性类型 | Relation | Activity value | Units | Action Type | 期刊 | PubMed Id | doi | Assay Aladdin ID |
|---|
提供 ≥98%(HPLC) 纯度,适用于对基线干扰要求严格的色谱和分析工作流程。
避光,-20°C储存,充氩。超低温运输 。请查阅批次 COA 获取详细规格。
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在色谱分析、有机合成和交叉偶联反应领域已被 14 篇同行评审文献引用。
离子霉素游离酸是一类对钙离子具有选择性的抗生素型离子载体,可将钙离子从水相萃取至有机相。同时它可作为阳离子转运载体,协助阳离子跨越溶剂阻隔层完成跨膜转运。 研究表明,该物质也能结合镁、锶、钡等离子,但结合亲和力远弱于钙离子。离子霉素游离酸由球丛链霉菌(Streptomyces conglobatus)发酵产生。 在科研领域,它是提升细胞内钙离子浓度的经典工具试剂,也常被用于质膜钙离子跨膜转运机制相关研究。 相较于经典钙离子载体 A23187,离子霉素作为钙离子转运载体的作用效果更强、钙选择性更优;除用于生物膜钙离子转运研究外,该试剂还可诱导胚胎皮层神经元发生凋亡性退变。
Ionomycin free acid is an antibiotic selective calcium ionophore, which can extract calcium ions from aqueous phase to organic phase. In addition, Ionomycin free acid acts as a transport carrier, which helps transport cations across solvent barriers. Studies indicate that this antibiotic can transport other ions such as Mg, Sr, and Ba with a weaker affinity. It is known that Ionomycin free acid is produced by Streptomyces conglobatus. Furthermore, Ionomycin free acid is a beneficial tool in research to raise intracellular calcium levels. Also this antibiotic can be used to study the calcium transport across the plasma membrane.
Ionomycin is more effective than A23187 as a Ca++ionophore. Ionomycin is used in research on Ca++ transport across biological membranes; Ionomycin induces apoptotic degeneration of embryonic cortical neurons
分类树(Taxonomy Tree)
| 界(kingdom) | 有机化合物 |
|---|---|
| 超类(Superclass) | 脂质和脂质样分子 |
| 类(Class) | 异戊烯醇脂质 |
| 亚类(Subclass) | 萜烯苷 |
| 中间层级节点(Intermediate Tree Nodes) | 暂无 |
| 直接上位类(Direct Parent) | 二萜苷 |
| 其他上位类(Alternative Parents) | 极长链脂肪酸 二萜类化合物 杂环脂肪酸 羟基脂肪酸 甲基支链脂肪酸 不饱和脂肪酸 丙烯酰化合物 乙烯基酸 烯酮类 四氢呋喃 酮类 仲醇 羧酸 二烷基醚 烯醇 多元醇 一元羧酸及其衍生物 氧环化合物 碳氢化合物衍生物 有机氧化物 |
| 分子骨架(Molecular Framework) | 脂肪族杂单环化合物 |
| 取代基(Substituents) | 丙烯酰基基团 - 羟基苯甲酸酯 - 脂肪族杂单环化合物 - α,β-不饱和酮 - 支链脂肪酸 - 羰基 - 羧酰胺基 - 羧酸衍生物 - 二烷基醚 - 二萜苷 - 二萜类化合物 - 乙烯醇 - 酮 - 乙醚 - 脂肪酸 - 脂肪酰基 - 杂环脂肪酸 - 烃衍生物 - 羟基脂肪酸 - 酮 - 甲基-支链脂肪酸 - 单羧酸或其衍生物 - 有机氧化物 - 有机氧化合物 - 有机杂环化合物 - 有机氧化合物 - 氧杂环 - 多醇 - 醛基 - 四氢呋喃 - 不饱和脂肪酸 - 维拉诺烷、阿提烷、粗疣烷或赫 - 乙烯基羧酸 |
| 描述(Description) | 该化合物属于二萜苷类有机化合物。这类二萜类化合物中,异戊二烯单元发生了糖基化反应。 |
| 外部描述符(External Descriptors) | cyclic ether - enol - polyunsaturated fatty acid - very long-chain fatty acid |
| 作用机制 | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | 参考文献 |
|---|
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| 批号(Lot Number) | 证书类型 | 货号 |
|---|---|---|
| 分析证书 | I139530 | |
| 分析证书 | I139530 | |
| 分析证书 | I139530 | |
| 分析证书 | I139530 | |
| 分析证书 | I139530 | |
| 分析证书 | I139530 | |
| 分析证书 | I139530 | |
| 分析证书 | I139530 | |
| 分析证书 | I139530 | |
| 分析证书 | I139530 | |
| 分析证书 | I139530 | |
| 分析证书 | I139530 | |
| 分析证书 | I139530 | |
| 分析证书 | I139530 | |
| 分析证书 | I139530 | |
| 分析证书 | I139530 | |
| 分析证书 | I139530 |
| 1. Xie Li, Yinan Zhang, Lingyan Xu, Aoxue Wang, Yejun Zou, Ting Li, Li Huang, Weicai Chen, Shuning Liu, Kun Jiang, Xiuze Zhang, Dongmei Wang, Lijuan Zhang, Zhuo Zhang, Zeyi Zhang, Xianjun Chen, Wei Jia, Aihua Zhao, Xinfeng Yan, Haimeng Zhou, Linyong Zhu, Xinran Ma, Zhenyu Ju, Weiping Jia, Congrong Wang, Joseph Loscalzo, Yi Yang, Yuzheng Zhao. (2022) Ultrasensitive sensors reveal the spatiotemporal landscape of lactate metabolism in physiology and disease. Cell Metabolism, [PMID:36309010] [10.1016/j.cmet.2022.10.002] |
| 2. Fang Wang, Xiu-Li Zhang, Jing-Ya Yang, Gang Zhou. (2023) Effects of interleukin-23 on the activation of mucosal-associated invariant T cells from oral lichen planus. JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, [PMID:37340721] [10.1177/03000605231180039] |
| 3. Wei Zhong, Leheng Feng, Wei Tian, Hongbo Qu, Haibo Xu, Ke Ning, Li Liu, Wei Liu, Xiaowei Gong, Hong Chen. (2023) SMURF1 inhibits the Th17 and Th17.1 polarization and improves the Treg/Th17 imbalance in systemic lupus erythematosus through the ubiquitination of RORγt. MOLECULAR IMMUNOLOGY, [PMID:37054520] [10.1016/j.molimm.2023.03.024] |
| 4. Jing Zhan, Qian S. Liu, Yuzhu Zhang, Zhendong Sun, Qunfang Zhou, Guibin Jiang. (2023) Silica nanoparticles trigger phosphatidylserine exposure in red blood cells and induce thrombosis risk. ENVIRONMENTAL POLLUTION, [PMID:37031850] [10.1016/j.envpol.2023.121591] |
| 5. Yang Sun, Tiancong Liu, Weiliang Bai. (2022) MAF bZIP Transcription Factor B (MAFB) Protected Against Ovalbumin-Induced Allergic Rhinitis via the Alleviation of Inflammation by Restoring the T Helper (Th) 1/Th2/Th17 Imbalance and Epithelial Barrier Dysfunction. Journal of Asthma and Allergy, [PMID:35250280] [10.2147/JAA.S335560] |
| 6. Wang Aoxue, Zou Yejun, Liu Shuning, Zhang Xiuze, Li Ting, Zhang Lijuan, Wang Ruwen, Xia Yale, Li Xie, Zhang Zhuo, Liu Tiemin, Ju Zhenyu, Wang Ru, Loscalzo Joseph, Yang Yi, Zhao Yuzheng. (2024) Comprehensive multiscale analysis of lactate metabolic dynamics in vitro and in vivo using highly responsive biosensors. Nature Protocols, [PMID:38307980] [10.1038/s41596-023-00948-y] |
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