胰岛素(Insulin)(人)

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为什么选择此级别

冻干粉,重组级提供 ≥95%(HPLC) 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。

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储存与运输

-20°C储存。超低温运输。请查阅批次 COA 获取详细规格。

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质量文档

SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。

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文献证明

在色谱分析、有机合成和交叉偶联反应领域已被 74 篇同行评审文献引用。

概述

无血清培养基补充剂（如胰岛素）对于常用哺乳动物细胞系的长期生长至关重要。当培养基中缺少胰岛素时，细胞形态和生长速度可能会受到干扰。重组人胰岛素已用在培养基中的间充质干细胞的成脂诱导。它已被用作气道上皮细胞的细胞培养基中的补充剂。它已用于细胞分化、GLUT4（4 型葡萄糖转运蛋白）易位测定的培养基中，并通过表面等离振子共振研究胰岛素与胰岛素受体的相互作用。

重组人胰岛素（rHu）在功能和结构上与天然人序列相同。由两个多肽链组成的激素，rHu 胰岛素的 A 链（21 个氨基酸）和 B 链（30 个氨基酸）通过半胱氨酸残基之间的二硫键共价连接。这种经基因工程改造的人胰岛素是全序列分子，通过重组 DNA 技术在面包酵母中生产。

产品介绍

人胰岛素是由胰岛β细胞分泌的一种多肽激素。胰岛素在许多细胞活动中发挥重要作用:如促进糖和氨基酸转运，提高合成代谢降低分解代谢，刺激细胞生长等等。胰岛素是无血清哺乳动物细胞培养基中的普遍添加物质。人胰岛素为由含有可高效表达人胰岛素基因的大肠杆菌，经发酵、分离、高度纯化、结晶和干燥制成。人胰岛素为51个氨基酸残基组成的蛋白质，分子量5808Da。

使用方法

使用之前溶解，一般用盐酸溶液(10mM)制成每 1ml中含胰岛素 1~2mg的溶液。

用途

仅用于R&D, 不可以用于临床治疗和服用

产品优势

无动物源性：生产,无外源性的病毒污染,生产过程不使用任何动物源原料。

质量稳定：批量生产,可保证稳定连续的批次生产;产品批次间无差异,质量稳定。

纯度高：比活高;宿主蛋白残留小于生物制品限度要求。

冻干粉:：易于储存和运输。

应用

无血清培养基补充剂（如胰岛素）对于常用哺乳动物细胞系的长期生长至关重要。当培养基中缺少胰岛素时，细胞形态和生长速度可能会受到干扰。

重组人胰岛素已用在培养基中的间充质干细胞的成脂诱导。

它已被用作气道上皮细胞的细胞培养基中的补充剂。

它已用于细胞分化、GLUT4（4 型葡萄糖转运蛋白）易位测定的培养基中，并通过表面等离振子共振研究胰岛素与胰岛素受体的相互作用

Insulin, recombinant human (rHu) is identical in function and structure to the native human sequence. A hormone consisting of two polypeptide chains, rHu Insulin′s A-chain (21 amino acids) and B-chain (30 amino acids) are covalently linked by disulfide bonds between cysteine residues. This genetically engineered human insulin is a full sequence molecule producted by recombinant DNA technology in baker′s yeast.

Product description

Human insulin is a polypeptide hormone secreted by pancreatic β-cells. Insulin plays a crucial role in numerous cellular activities, such as promoting the transport of glucose and amino acids, enhancing anabolism and reducing catabolism, stimulating cell growth, and more. Insulin is a common additive in serum-free mammalian cell culture media. Human insulin is produced through fermentation, separation, high-level purification, crystallization, and drying from Escherichia coli containing a gene that efficiently expresses human insulin. Human insulin is a protein consisting of 51 amino acid residues, with a molecular weight of 5808 Da.

Usage

Before use, dissolve it in a solution made with hydrochloric acid solution (10mM) to obtain a concentration of 1~2mg insulin per 1ml.

Purpose

It is only for R&D purposes and cannot be used for clinical treatment or consumption

Advantages and Specific

No animal-derived sources: The production process is free from exogenous viral contamination and does not utilize any animal-derived raw materials.

Stable quality: Mass production ensures stable and continuous batch production; there is no difference between product batches, and the quality remains stable.

High purity: high specific activity; host protein residuals are below the limit requirements for biological products.

Freeze-dried powder: Easy to store and transport.

Application

Serum-free medium supplements such as insulin are essential for long-term growth of commonly used mammalian cell lines. When insulin is absent from media, cell may exhibit disturbances in morphology and growth rate.

Recombinant Human Insulin has been used in the media for adipogenic induction of mesenchymal stem cells.

It has been used as a supplement in the cell culture media of airway epithelial cells.

It has been used in the culture media for differentiation of cells, GLUT4 (glucose transporter type 4) translocation assay and to study interaction of insulin with insulin receptor via surface plasmon resonance.

规格

产品名称

胰岛素(Insulin)(人)

规格或纯度

重组,冻干粉,≥95%(HPLC),大肠杆菌表达

生化机理

由胰岛β-细胞所产生的二链多肽激素。其分子量为~5800 Da。α链和β链是由两个链间二硫键所连接的。α链含有一个链间二硫键。胰岛素可调节细胞对葡萄糖、氨基酸和脂肪酸的摄取、利用和储存，并抑制糖原、蛋白质和脂肪的分解。

CAS编号和信息

11061-68-0

分子类型

肽

储存与运输

物理形态

固体

浓度

大肠杆菌表达

储存条件

-20°C储存

运输条件

超低温运输

技术文档

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质检证书（CoA,COO,BSE/TSE 和分析图谱)

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技术文档和文章

细胞培养中动物源血清、功能化血清及非动物源培养补充体系的选择策略

目录：技术文章

探索主题:

细胞培养动物源血清功能化血清非动物源培养体系无血清培养化学限定培养基 xeno-free 培养补充体系

Selection Strategies for Animal-Derived Serum, Functionalized Serum, and Non-Animal-Derived Culture Supplementation Systems in Cell Culture

目录：技术文章

探索主题:

cell culture xeno-free Animal-Derived Serum Functionalized Serum Non-Animal-Derived Culture System Serum-Free Culture Chemically Defined Medium Culture Supplementation System

糖尿病动物模型建立与评价方法

目录：技术文章

探索主题:

糖尿病动物造模 STZ诱导模型四氧嘧啶模型高脂饮食模型 HFD+STZ模型 NOD小鼠 db/db小鼠 ZDF大鼠

Establishment and Evaluation Methods of Diabetic Animal Models

目录：技术文章

探索主题:

diabetic animal modeling STZ-induced model alloxan model high-fat diet model HFD+STZ model NOD mice db/db mice ZDF rats

Endocrinology/Hormones（内分泌与激素）在代谢调控、生殖功能与疾病研究中的应用

目录：技术文章

探索主题:

Hormones 胰岛素 HPA轴 GPCR 内分泌激素 Endocrinology 甲状腺激素类固醇激素性激素

Applications of Endocrinology/Hormones in Metabolic Regulation, Reproductive Function, and Disease Research

目录：技术文章

探索主题:

Hormones Insulin HPA axis GPCR Endocrinology thyroid hormone steroid hormone sex hormone

多肽药物的分子特征、主要类型与开发策略

目录：技术文章

探索主题:

靶向递送多肽药物激素肽天然活性肽多肽疫苗多肽药物偶联物细胞穿透肽多肽修饰

Molecular Characteristics, Major Types, and Development Strategies of Peptide Drugs

目录：技术文章

探索主题:

targeted delivery Peptide Drugs Peptide Hormones Natural Bioactive Peptides Peptide Vaccines Peptide-Drug Conjugates Cell-Penetrating Peptides Peptide Modification

Amylin receptor靶向减重：受体组成、作用机制与代表药物

目录：技术文章

探索主题:

减重 Amylin receptor Amylin Calcitonin receptor RAMP Cagrilintide Pramlintide

Amylin Receptor-Targeted Weight Loss: Receptor Composition, Mechanisms of Action, and Representative Drugs

目录：技术文章

探索主题:

weight loss Amylin receptor Amylin Calcitonin receptor RAMP Cagrilintide Pramlintide

ActRIIA/ActRIIB在减重中的肌肉保护与脂肪调控

目录：技术文章

探索主题:

ActRIIB Activin A ActRIIA Myostatin Bimagrumab 骨骼肌体成分

ActRIIA/ActRIIB in Weight Loss: Muscle Preservation and Adipose Regulation

目录：技术文章

探索主题:

ActRIIB Activin A ActRIIA Myostatin Bimagrumab skeletal muscle body composition

新兴减脂靶点：INHBE/Activin E–ALK7信号轴

目录：技术文章

探索主题:

脂解 INHBE Activin E ALK7 ACVR1C 内脏脂肪肝—脂肪轴

Emerging Fat-Loss Target: The INHBE/Activin E–ALK7 Signaling Axis

目录：技术文章

探索主题:

Lipolysis INHBE Activin E ALK7 ACVR1C visceral fat liver–adipose axis

此产品的引用文献

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引用文献

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