微晶纤维素非常强健且具有化学惰性，因此，是非常理想的载体。 API-分层的微晶纤维素可填充入胶囊或压制成片剂。它们有很紧密的粒度分布，可以更好的控制和提高批次间API释放的一致性。粒度的均一性使封装或压片时的风险最小化，带来更高的API含量均一性。另外，可以在多种浓缩物中运用不同的APIs，并且在一个单位剂量中与丸芯包衣结合。
产品规格参数表
| 货号 | 激光衍射平均粒径（µm） | 体积密度（g/mL） | 主要应用 | | M489093-01 | 15 | max 0.26 | 非常好的等级，给人一种愉悦的口感，掩盖苦味并支持风味。 | | M489093-02 | 65 | 0.26–0.31 | 精细标准 MCC 等级，特别适用于湿法制粒、碾压和滚圆。 非常高的压实性。 | | M489093-03 | 65 | 0.26-0.34 | 质量与 101/50M 级相同，但水分含量非常低 (< 1.5 %)，适用于加工对水敏感的活性物质。 | | M489093-04 | 65 | 0.35-0.46 | 质量与 101 级相同，但增加了堆积密度并改善了流动性能。 | | M489093-05 | 130 | 0.28-0.33 | 中型标准 MCC 等级，适用于大多数可直接压缩的活性物质。 兼具良好的流动性和高压实性。 | | M489093-06 | 130 | 0.30-0.36 | 质量与 102/90M 级相同，但水分含量非常低 (< 1.5 %)，适用于加工水敏感活性物质。 | | M489093-07 | 130 | 0.35-0.50 | 与等级 102/90M 相同的质量，但增加了堆积密度并改善了流动性能。 特别适用于高速压片和加工高密度活性物质。 | | M489093-08 | 170/175 | 0.28-0.34 | 粗略的 DC 级 MCC。 | | M489093-09 | 180 | 0.30-0.36 | 粗级 MCC，结合了良好的压实性和高结合能力以及出色的流动性。 即使在与低浓度的精细活性物质一起使用时，也能以低重量变化提供良好的含量均匀性。 | | M489093-10 | 170 | 0.32-0.40 | 与 12 级质量相同，但水分含量非常低 (<1.5 %)，用于加工水敏感活性物质。 | | M489093-11 | 250 | 0.31-0.37 | 具有出色流动性能的大尺寸 MCC 等级，适用于各种直接压缩配方。 | | M489093-12 | 250 | 0.33-0.40 | 与等级 200/LP200 的质量相同，但水分含量非常低 (<1.5 %)，适用于加工对水敏感的活性物质。 | | M489093-13 | 220 | 0.20-0.37 | 粗粒径微晶纤维素，可压性和粘合性好，流动性佳。即使用于细粒径低含量的活性成分，也能得到含量均匀度好，片重差异小的片剂。 |
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用途
微晶纤维素广泛应用于药物制剂，主要在口服片剂和胶囊中用作稀释剂和粘合剂，不仅可用于湿法制粒也可用于干法直接压片。还有一定的润滑和崩解作用，在片剂制备中非常有用。
优势
微晶纤维素的优势：
1.生物惰性，
2.不溶于水，
3.耐潮耐热，
4.适用于包衣和压片。
Microcrystalline cellulose is very strong and chemically inert, so it is a very ideal carrier. API layered microcrystalline cellulose can be filled into capsules or pressed into tablets. They have a very tight particle size distribution, which can better control and improve the consistency of API release between batches. The uniformity of particle size minimizes the risk of packaging or tablet pressing, resulting in higher uniformity of API content. In addition, different APIs can be used in a variety of concentrates and combined with pellet core coating in a unit dose.
Product specifications
| SKU | Average Particle Size by Laser Diffraction (µm) | Bulk Density (g/mL) | Main Application | | M489093-01 | 15 | max 0.26 | Very fine grade, which gives a pleasant mouth feeling, masks bitter tastes and supports flavors. | | M489093-02 | 65 | 0.26–0.31 | Fine standard MCC grade, especially suited for wet granulation, roller compaction and spheronization. Very high compactibility. | | M489093-03 | 65 | 0.26-0.34 | Same quality as grade 101/50M, but very low moisture content (< 1.5 %) for processing water-sensitive actives. | | M489093-04 | 65 | 0.35-0.46 | Same quality as grade 101, but increased bulk density and improved flow properties. | | M489093-05 | 130 | 0.28-0.33 | Medium size standard MCC grade, suited for the majority of directly compressible actives. Combines good flow and high compactibility. | | M489093-06 | 130 | 0.30-0.36 | Same quality to grades 102/90M, but very low moisture content (< 1.5 %) for processing water-sensitive actives | | M489093-07 | 130 | 0.35-0.50 | Same quality to grade 102/90M, but increased bulk density and improved flow properties. Especially suited for high speed tableting and processing high density actives. | | M489093-08 | 170/175 | 0.28-0.34 | Coarse, DC-grade MCC. | | M489093-09 | 180 | 0.30-0.36 | Coarse grade MCC, combines good compactibility and high binding capacity with outstanding flow. Provides good content uniformity at low weight variation – even when used with low concentrations of fine actives. | | M489093-10 | 170 | 0.32-0.40 | Same quality to grade 12, but very low moisture content (<1.5 %) for processing water-sensitive actives. | | M489093-11 | 250 | 0.31-0.37 | Large size MCC grade with excellent flow properties for a variety of direct compression formulations. | | M489093-12 | 250 | 0.33-0.40 | Same quality to grades 200/LP200, but very low moisture content (<1.5 %) for processing water-sensitive actives. | | M489093-13 | 220 | 0.20-0.37 | Coarse grained microcrystalline cellulose has good compressibility and adhesion, and good fluidity. Even for active ingredients with low content and fine particle size, tablets with good content uniformity and small differences in tablet weight can be obtained. |
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Benefits
1.High compactability,
2.Robust tablets with low friability,
3.High production yields,
4.Practically inert – compatible with most APIs,
5.Created from sustainable organic materials,
6.Contains no additives, impurities, or irradiated components,
7.Advanced carton packaging design for fast NIR identification.
A2416611
危险品化学品经营许可证（带存储）