中性粒细胞来源乳铁蛋白是一种多功能糖蛋白,储存于多形核中性粒细胞的次级颗粒中,并在免疫应答过程中释放。除存在于唾液、泪液、乳汁等外分泌液中之外,中性粒细胞来源的乳铁蛋白在机体固有防御机制中起到关键作用。释放后,它以高亲和力结合游离铁,限制入侵细菌可利用的铁元素,进而发挥强效抑菌与杀菌作用。这种铁螯合作用不仅抑制微生物增殖,还可调节感染部位的炎症反应。此外,中性粒细胞乳铁蛋白可调控肠道铁吸收,参与铁稳态维持,避免铁过载或铁缺乏。
常见研究用途
临床上,中性粒细胞乳铁蛋白水平异常与炎症性疾病、感染及部分自身免疫性疾病相关。其抗菌与免疫调节特性,使其成为治疗感染、炎症性疾病以及维护免疫健康方面极具潜力的候选物质。
常见应用:免疫系统相关研究。
供体原料由完成全套传染病筛查的供应商提供。原料采集前已完成检测,HIV、HBV、HCV 及梅毒均为阴性。
Neutrophil lactoferrin is a multifunctional glycoprotein stored in the secondary granules of polymorphonuclear neutrophils and released during immune responses. In addition to its presence in exocrine secretions such as saliva, tears, and milk, neutrophil-derived lactoferrin plays a pivotal role in the body’s innate defense mechanisms. Upon release, it binds free iron with high affinity, limiting iron availability to invading bacteria and thereby exerting potent bacteriostatic and bactericidal effects. This iron-sequestration not only inhibits microbial growth but also helps modulate inflammatory responses at sites of infection. Furthermore, neutrophil lactoferrin regulates intestinal iron absorption, contributing to iron homeostasis and preventing iron overload or deficiency.
Common research uses
Clinically, altered levels of neutrophil lactoferrin have been associated with inflammatory diseases, infections, and certain autoimmune conditions. Its antimicrobial and immunomodulatory properties make it a promising candidate for therapeutic applications in treating infections, inflammatory disorders, and supporting immune health.
Common uses include immune system research.
Donor material is obtained from suppliers that perform a comprehensive infectious disease screening panel. This material was tested and found negative for HIV, HBV, HCV, and syphilis prior to collection.