核糖核酸酶A 来源于牛胰腺

CAS: 9001-99-4 货号: R104906 EC号: 232-646-6 PubChem CID: 9369
有货
级别和纯度: EnzymoPure™ ? EnzymoPure™ —— 阿拉丁的高质量酶解决方案系列。当酶纯度和明确活性决定检测或工艺性能时使用。 ≥ 50 Kunitz units/mg
Accession #
P61823
生物活性
≥ 50 Kunitz units/mg enzyme powder
★
规格
库存
价格
数量
10mg
R104906-10mg
现货 Stock Image
¥69.90
50mg
R104906-50mg
现货 Stock Image
¥199.90
250mg
R104906-250mg
现货 Stock Image
¥599.90
500mg
R104906-500mg
现货 Stock Image
¥999.90
1g
R104906-1g
现货 Stock Image
¥1,699.90
请输入您要添加的产品数量
🧪
为什么选择此级别

EnzymoPure™ 级 ,适用于对基线干扰要求严格的色谱和分析工作流程。

🌡

储存与运输

避光,-20°C储存,干燥,避免反复冻融。超低温运输 。请查阅批次 COA 获取详细规格。

📋

质量文档

SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。

📚

文献证明

在色谱分析、有机合成和交叉偶联反应领域已被 37 篇同行评审文献引用。

概述

核糖核酸酶A (RNase A) 是一种内切核糖核酸酶,在嘧啶核苷酸后裂解单链RNA的磷酸二酯键。它可切割3′磷酸基末端(例如,pG-pG-pC-pA-pG将切割为pG-pG-pCp 和A-pG)。对单链RNA表现出最高活性。RNase A是含有四个二硫键的单链多肽。它与RNase B不同,并非糖蛋白。核糖核酸酶不会水解DNA,因为DNA缺乏形成环状中间体所必需的2′-OH基团。RNase A还可以水解蛋白质样品中的RNA。RNase A可被His12和His119的烷基化抑制并被钾盐和钠盐活化。RNAse在重金属离子存在时受到抑制。此外,RNase也被DNA竞争性抑制。
应用:
RNase A用于去除DNA质粒和基因组DNA制品和蛋白质样品中的RNA,
RNase A还用于RNA序列分析和保护测定,
RNase A已用作计算辅助药物设计的工具,
RNase A为RNA序列分析提供支持,
RNase A水解蛋白质样品中的RNA,
RNase A为DNA纯化提供支持。
生化与生理作用

核糖核酸酶A是一种内切核糖核酸酶,可在嘧啶核苷酸后切割单链RNA。 它在3'磷酸基末端进行攻击。 核糖核酸酶不会水解DNA,因为DNA缺乏形成环状中间体所必需的2′-OH基团。RNA酶还可以水解蛋白质样品中的RNA。 RNase A可被His12和His119的烷基化所抑制并被钾盐和钠盐所活化。

细胞定位:Secreted.

序列相似性:Belongs to the pancreatic ribonuclease family.

RNase A, Ribonuclease A, is an endoribonuclease that cleaves the phosphodiester bonds of single strand RNA after pyrimidine nucleotides. It attacks at the 3′ phosphate end (For example pG-pG-pC-pA-pG will be cleaved to give pG-pG-pCp and A-pG). The highest activity is exhibited with single stranded RNA. RNase A is a single chain polypeptide containing 4 disulfide bridges. In contrast to RNase B, it is not a glycoprotein. Ribonucleases do not hydrolyze DNA, because the DNA lacks 2′-OH groups essential for the formation of cyclic intermediates. RNase A can also hydrolyze RNA from protein samples. RNase A can be inhibited by alkylation of His12 and His119 and activated by potassium and sodium salts. RNAse is inhibited in the presence of heavy metal ions. RNase is also inhibited competitively by DNA.

Application:
RNase A is used to remove RNA from DNA plasmid and genomic DNA preparations and protein samples.
RNase A is also used in RNA sequence analysis and protection assays.
RNase A has been used as a tool for computer-aided drug design.
RNase A supports the analysis of RNA sequences.
RNase A hydrolyze RNA contained in protein samples.
Purification of DNA is supported by RNase A.

Biochem/physiol Actions
Ribonuclease A is an endoribonuclease that cleaves single stranded RNA after pyrimidine nucleotides. It attacks at the 3′ phosphate end. Ribonucleases do not hydrolyze DNA, because the DNA lacks 2′-OH groups essential for the formation of cyclic intermediates. RNase can also hydrolyze RNA from protein samples. RNase A can be inhibited by alkylation of His12 and His119 and activated by potassium and sodium salts.

Cell localization: Secreted

Sequence similarity: Belongs to the pancreatic ribonucleotide family

规格

产品名称
核糖核酸酶A 来源于牛胰腺
别名
RNA酶,RNase A ,RNase I | RNA酶 | 胰腺核糖核酸酶 | 核糖核酸酶 I | 内切核糖核酸酶 I | 碱性核糖核酸酶 | 核糖核酸 3'- 嘧啶寡核苷酸水解酶 | 核糖核酸 3′-嘧啶寡核苷酸水解酶 | 胰核糖核酸酶
英文别名
DL-(3-aminopropanoyl)histidine | L-Histidine, N-.beta.-alanyl- | SCHEMBL33768 | NSC524045 | NSC-524045 | L-HISTIDINE, N-beta-ALANYL- | MFCD00005207 | 2-(3-amino-propanoylamino)-3-(1H-imidazol-4-yl)-propionic acid | DTXSID50861860 | 2-(3-aminopropanoylamin
规格或纯度
EnzymoPure™, ≥ 50 Kunitz units/mg
生化机理
Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single-stranded and double-stranded RNA. Catalytic activity: an [RNA] containing cytidine + H2O = an [RNA]-3'-cytidine-3'-phosphate + a 5'-hydroxy-ribonucleotide-3'-[RNA]. an [RNA] containing uridine + H2O = an [RNA]-3'-uridine-3'-phosphate + a 5'-hydroxy-ribonucleotide-3'-[RNA].
生物活性
≥ 50 Kunitz units/mg enzyme powder
种属
牛(Bovine)
来源
天然
CAS编号和信息
9001-99-4
酶学委员会编号
EC 3.1.27.5 Transferred entry: 4.6.1.18
分子类型
酶
储存与运输
物理形态
冻干(Lyophilized)
浓度
≥ 50 Kunitz units/mg
储存条件
避光,-20°C储存,干燥,避免反复冻融
运输条件
超低温运输
稳定性与储存
长期储存-20℃(24个月);复溶后建议分装,避免反复冻融;避光;密封。
单位定义
1 个 Kunitz 单位(Kunitz unit):在 25℃和 pH 5.0 条件下,使 RNA 以 k (速度常数) 等于单位1 的速率水解的酶的数量。

技术文档

📋 安全数据表 (SDS)

全面的危险、操作、储存及法规合规文件。

下载 SDS →

✅ 分析证书 (COA)

批次质量数据。输入批号以获取对应 COA。

查询 COA →

📊 产品数据表

产品规格和应用的快速参考摘要。

查看数据表 →

🔬 规格说明书

该级别的完整质量属性和验收标准。

查看规格说明 →

高级数据

关联靶点(人)
ACHN (49357 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CAKI-1 (44928 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
CCRF-CEM (65223 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
COLO 205 (50209 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
DU-145 (51482 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HL-60 (67320 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HT-29 (80576 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
K562 (73714 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
KM12 (47707 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
M14 (47487 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
MCF7 (126967 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
MOLT-4 (49676 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
OVCAR-3 (48710 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
OVCAR-4 (44535 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
OVCAR-5 (45555 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
OVCAR-8 (47708 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
PC-3 (62116 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
RPMI-8226 (44974 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SF-295 (48000 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SK-MEL-2 (46422 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SK-MEL-28 (48833 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SK-MEL-5 (47095 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SN12C (47755 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SNB-19 (46794 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
TK-10 (45540 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
U-251 (51189 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
UACC-257 (46019 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
UO-31 (46270 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
786-0 (47912 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
A549 (127892 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
NCI/ADR-RES (33767 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
T47D (39041 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
EKVX (44102 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
NCI-H322M (45589 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HCC 2998 (41480 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HCT-116 (91556 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HOP-92 (41141 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Hs-578T (29457 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
NCI-H460 (60772 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SF-268 (49410 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
IGROV-1 (47897 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
LOX IMVI (44321 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
HOP-62 (47048 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
MDA-MB-435 (38290 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
MDA-N (28205 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
Malme-3M (44254 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
MDA-MB-231 (73002 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
SNB-75 (44215 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
NCI-H226 (44470 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
NCI-H23 (49055 活性数据)
活性类型 Relation Activity value Units Action Type 期刊 PubMed Id doi Assay Aladdin ID
作用机制
作用机制 Action Type target ID Target Name Target Type Target Organism Binding Site Name 参考文献
质检证书(CoA,COO,BSE/TSE 和分析图谱)
C of A & Other Certificates(BSE/TSE, COO):
输入批号以搜索分析图谱:

通过匹配包装上的批号来查找并下载产品的 COA,每批产品都进行了严格的验证,您可放心使用!

找到23个结果

批号(Lot Number) 证书类型 货号
H2615630 分析证书 R104906
H2615627 分析证书 R104906
H2615625 分析证书 R104906
J2226747 分析证书 R104906
J2226749 分析证书 R104906
F2213080 分析证书 R104906
A2422294 分析证书 R104906
A2422160 分析证书 R104906
A2422159 分析证书 R104906
F2528045 分析证书 R104906
H2324351 分析证书 R104906
H2324352 分析证书 R104906
H2324354 分析证书 R104906
H2324353 分析证书 R104906
J2226748 分析证书 R104906
F2213081 分析证书 R104906
C2013135 分析证书 R104906
B2514027 分析证书 R104906
I2124359 分析证书 R104906
J2226750 分析证书 R104906
J2226751 分析证书 R104906
F2213420 分析证书 R104906
F2213083 分析证书 R104906
技术文档和文章
CRISPR-Cas9和靶向基因组编辑
CRISPR/Cas9 and targeted genome editing
CUT&RUN-seq实验方案
细胞凋亡DNA片段化分析实验方案
双交联ChIP方案
Dual Cross-linking ChIP Protocol
蛋白酶K与核糖核酸酶A
Proteinase K and Ribonuclease A
质粒的五个关键结构特征
Five Key Structural Features of Plasmids
Proteinase K常见问题
Proteinase K: Frequently Asked Questions
白介素29(IL-29/IFN-λ1):分子特征、信号网络与科研应用体系
Interleukin-29 (IL-29/IFN-λ1): Molecular Features, Signaling Networks, and a Systematic Framework for Research Applications
双链脱氧核糖核酸酶(dsDNase)介导的双链DNA水解:酶学特征、方法学策略与生物分析应用综述
dsDNase-Mediated Hydrolysis of Double-Stranded DNA: Enzymatic Characteristics, Methodological Strategies, and Bioanalytical Applications
二苯胺的理化特性、分析应用及其与DNA显色反应综述
Physicochemical Properties of Diphenylamine, Analytical Applications, and a Review of Its DNA Colorimetric Reaction
细胞核酸代谢与调控酶在基因表达、RNA稳态与免疫防御中的功能体系综述
A Functional Systems Review of Cellular Nucleic Acid Metabolism and Regulatory Enzymes in Gene Expression, RNA Homeostasis, and Immune Defense
葡聚糖凝胶的结构特征、操作方法及分离应用
Structural Characteristics, Operational Methods, and Separation Applications of Dextran Gels
CUT&RUN-seq protocol
Apoptosis DNA Fragmentation Analysis Protocol
RNA结构解析中核酸酶探针怎么选?RNase T1、RNase A、RNase V1与S1核酸酶比较
How to Select Nuclease Probes for RNA Structure Analysis? Comparison of RNase T1, RNase A, RNase V1, and S1 Nuclease
核糖核酸酶家族的催化机制、底物特异性与实验应用
Catalytic Mechanisms, Substrate Specificity, and Experimental Applications of the Ribonuclease Family
此产品的引用文献
溶液计算器