Immobilized Human CD161, His Tag at 2 μg/mL (100 μL/Well) on the plate. Dose response curve for Anti-CD161 Antibody, hFc Tag with the EC50 of 5.3ng/mL determined by ELISA.
C-type lectin domain family 5 member B | HNKR-P1a | Natural killer cell surface protein P1A | NKR-P1A | CD161 antigen | CD161 | CLEC5B | C-type lectin domain family 5 member B | HNKR-P1a | killer cell lectin-like receptor subfamily B member 1 | killer cel
Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Also binds to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells.
Post-translational: N-glycosylated. Contains sialic acid residues.
生物活性
Immobilized Human CD161, His Tag at 2 μg/mL (100 μL/Well) on the plate. Dose response curve for Anti-CD161 Antibody, hFc Tag with the EC50 of 5.3ng/mL determined by ELISA.
Lyophilized from 10mM PBS, 5% Trehalose, 5% Mannitol, pH7.4.
复溶
Reconstitute in sterile water to a concentration of 0.1-0.5 mg/ml.
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
长期储存-20~-80℃(1年);复溶后建议分装,避免反复冻融。
图片
Recombinant Human CD161 Protein (rp143822) - Protein Bioactivity
Immobilized Human CD161 Protein at 1.0 μg/mL can bind CD161 Mouse mAb (Ab094006) with the EC50 of 352.3 ng/mL.
Recombinant Human CD161 Protein (rp143822) - SDS-PAGE
2 μg/lane of Recombinant Human CD161 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing the band at 38 kDa.