Recombinant Human CEACAM-3/CD66d Protein

功能和特点
  • 表达系统: E. coli
  • Accession #: P40198
  • 蛋白标签: C-His
  • 生物活性: When Recombinant Human CEACAM‑3/CD66d is immobilized at 2 µg/mL (100 µL/well), the concentration of Recombinant Human CEACAM-7 that produces 50% of the optimal binding response is 0.6-3.6 μg/mL.
  • 内毒素水平: <1.0 EU/μg
有货

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库存信息

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库存信息

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库存信息

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货号 (SKU) 包装规格 是否现货 价格 数量
rp144254-10μg
10μg 现货 Stock Image
rp144254-50μg
50μg 现货 Stock Image
rp144254-100μg
100μg 现货 Stock Image
rp144254-1mg
1mg 期货 Stock Image

基本描述

产品名称 Recombinant Human CEACAM-3/CD66d Protein
别名 癌胚抗原相关细胞粘附分子3(CEACAM3)重组蛋白 | 重组人 CEACAM-3/CD66d 蛋白
英文别名 Carcinoembryonic antigen CGM1 | carcinoembryonic | Carcinoembryonic antigen CGM1 | Carcinoembryonic antigen gene family member 1 | carcinoembryonic antigen related cell adhesion molecule 3 | Carcinoembryonic antigen-related cell adhesion molecule 3 | cd66
规格或纯度 ActiBioPure™, Bioactive, Animal Free, Carrier Free, Azide Free, ≥95%(SDS-PAGE)
产品介绍


Purity
≥95% (SDS-PAGE)
Endotoxin level
<1.0 EU/μg
Function
Major granulocyte receptor mediating recognition and efficient opsonin-independent phagocytosis of CEACAM-binding microorganisms, including Neissiria, Moxarella and Haemophilus species, thus playing an important role in the clearance of pathogens by the innate immune system. Responsible for RAC1 stimulation in the course of pathogen phagocytosis.

生物活性 When Recombinant Human CEACAM‑3/CD66d is immobilized at 2 µg/mL (100 µL/well), the concentration of Recombinant Human CEACAM-7 that produces 50% of the optimal binding response is 0.6-3.6 μg/mL.
内毒素水平 <1.0 EU/μg
表达系统 E. coli
种属 Human
氨基酸 35-155 aa
序列 MKLTIESMPLSVAEGKEVLLLVHNLPQHLFGYSWYKGERVDGNSLIVGYVIGTQQATPGAAYSGRETIYTNASLLIQNVTQNDIGFYTLQVIKSDLVNEEATGQFHVYQENAPGLPVGAVAGHHHHHH
纯度 ≥95% (SDS-PAGE)
蛋白标签 C-His
无载体 Yes
无动物源 Yes
Accession # P40198
来源 重组表达
预测分子量 14 kDa
SDS-PAGE 15 - 20 kDa, under reducing conditions; 15 - 20 kDa, under non-reducing conditions.

AI解读

图片

Recombinant Human CEACAM-3/CD66d Protein (rp144254) - Protein Bioactivity
Immobilized Recombinant Human CEACAM-3/CD66d Protein (rp144254) at 2.0 μg/mL, the concentration of Recombinant Human CEACAM-7 that produces 50% of the optimal binding response is 2.2 μg/mL.

Recombinant Human CEACAM-3/CD66d Protein (rp144254) - SDS-PAGE
3 μg/lane of Recombinant Human CEACAM-3/CD66d Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 15 - 20 kDa.

产品规格参数

物理形态 冻干(Lyophilized)
储存缓冲液 Lyophilized from 10mM PBS, 5% Trehalose, 5% Mannitol, pH 7.4
复溶 Reconstitute in sterile water to a concentration of 0.1-0.5 mg/ml.
储存温度 -20°C储存,避免反复冻融
运输条件 超低温冰袋运输
稳定性与储存 在 -20~-80℃ 下可保存 1 年以上。收货后建议分装。避免冷冻/解冻循环。
分子类型 蛋白质

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找到3个结果

批号(Lot Number) 证书类型 日期 货号
ZJ24F0709098 分析证书 24-08-08 rp144254
ZJ24F0709097 分析证书 24-08-08 rp144254
ZJ24F0709096 分析证书 24-08-08 rp144254

参考文献

1. Khan, W N WN and 5 more authors..  (1992)  Identification of three new genes and estimation of the size of the carcinoembryonic antigen family..  Genomics,  [PMID:1427854]
2. Kuroki, M M and 6 more authors..  (1991)  Molecular cloning of nonspecific cross-reacting antigens in human granulocytes..  The Journal of biological chemistry,  (25): [PMID:2050678]
3. Nagel, G G and 5 more authors..  (1993)  Genomic organization, splice variants and expression of CGM1, a CD66-related member of the carcinoembryonic antigen gene family..  European journal of biochemistry,  (15): [PMID:8508798]
4. Streichert, T T and 5 more authors..  (2001)  The microbial receptor CEACAM3 is linked to the calprotectin complex in granulocytes..  Biochemical and biophysical research communications,  (23): [PMID:11708798]
5. McCaw, Shannon E SE, Schneider, Jutta J, Liao, Edward H EH, Zimmermann, Wolfgang W and Gray-Owen, Scott D SD..  (2003)  Immunoreceptor tyrosine-based activation motif phosphorylation during engulfment of Neisseria gonorrhoeae by the neutrophil-restricted CEACAM3 (CD66d) receptor..  Molecular microbiology,  [PMID:12864848]
6. Schmitter, Tim T, Agerer, Franziska F, Peterson, Lisa L, Munzner, Petra P and Hauck, Christof R CR..  (2004)  Granulocyte CEACAM3 is a phagocytic receptor of the innate immune system that mediates recognition and elimination of human-specific pathogens..  The Journal of experimental medicine,  (5): [PMID:14707113]

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