Measured by its binding ability in a functional ELISA. When Recombinant Human CD161 Fc Chimera is coated at 5 μg/mL (100 μL/well), the concentration of recombinant human CLEC-2A Fc Chimera that produces 50% optimal binding response is found to be approximately 2-10 μg/mL.
Purity ≥95% SDS-PAGE. Endotoxin level <0.1 EU/µg Function Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Binds also to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells.
规格
产品名称
Recombinant Human CD161 Protein
别名
重组人CD161蛋白
英文别名
CD161 antigen | CD161 | CLEC5B | C-type lectin domain family 5 member B | HNKR-P1a | killer cell lectin-like receptor subfamily B member 1 | killer cell lectin-like receptor subfamily B, member 1 | KLRB1 | Ly59 | Natural killer cell surface protein P1A |
Measured by its binding ability in a functional ELISA. When Recombinant Human CD161 Fc Chimera is coated at 5 μg/mL (100 μL/well), the concentration of recombinant human CLEC-2A Fc Chimera that produces 50% optimal binding response is found to be approximately 2-10 μg/mL.
Lyophilized from 10mM PBS, 5% Trehalose, 5% Mannitol, pH7.4.
复溶
Reconstitute in sterile water to a concentration of 0.1-0.5 mg/ml.
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
在 -20~-80℃ 下可保存 1 年以上。复溶后建议分装。避免冷冻/解冻循环。
图片
Recombinant Human CD161 Protein (rp167732) - SDS-PAGE 2 μg/lane of Recombinant Human CD161 Protein was resolved with SDS-PAGE under reducing (R) conditions and visualized by Coomassie® Blue staining, showing the band at 58 kDa under reducing conditions.
ZJ25F0926550
危险品化学品经营许可证（带存储）