级别和纯度: 无载体?无载体（Carrier Free）—— 不含添加的载体蛋白/稳定剂。当载体（如 BSA）会干扰偶联或敏感检测时使用。His标签?组氨酸(His) 标签级 —— 带有 His 标签的重组蛋白，供亲和纯化/检测。用于纯化、固定或检测带标签蛋白。≥90%(SDS-PAGE)expressed in E. coli; 见COA
a disintegrin and metalloprotease domain 10 | a disintegrin and metalloproteinase domain 10 | AD10 | ADAM 10 | ADAM metallopeptidase domain 10 | ADAM10 | CD156c antigen | CD156c | CDw156 | disintegrin and metalloproteinase domain-containing prote
规格或纯度
无载体,His标签,≥90%(SDS-PAGE),expressed in E. coli; 见COA
生化机理
ADAM10 is part of the ADAM family which are cell surface proteins with a distinctive structure possessing both potential adhesion and protease domains. ADAM10 cleaves many proteins including TNF-alpha and E-cadherin. ADAM10 cleaves the membrane-bound precursor of tnf-alpha at 76- ala-|-val-77 to its mature soluble form. ADAM10 is in charge for the proteolytic release of several other cell-surface proteins, including ephrin-a2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein. ADAM10 is involved in the normal cleavage of the cellular prion protein. ADAM10 is involved in the cleavage of the adhesion molecule l1 at the cell surface and in the release of membrane vesicles, suggesting a vesicle-based protease activity. ADAM10 controls the proteolytic processing of notch and mediates lateral inhibition during neurogenesis.
Post-translational: The precursor is cleaved by furin and PCSK7.
Recombinant Human ADAM10 Protein (rp169543) - SDS-PAGE
3 μg/lane of Recombinant Human ADAM10 Protein was resolved with SDS-PAGE under reducing (R) and visualized by Coomassie® Blue staining, showing a band at 52.1 kDa.
ZJ26F0131777
危险品化学品经营许可证（带存储）