Recombinant Human ErbB2/HER2 Protein

Name: Recombinant Human ErbB2/HER2 Protein
SKU: rp169607
Availability: InStock

货号: rp169607

COA

有货

级别和纯度: 无动物源 ? 无载体 ? 生物活性 ? ActiBioPure™ ? 无叠氮钠 ? His标签 ? PBS Only ? ≥90%(SDS-PAGE)

Accession #

P04626

蛋白标签

C-His

表达系统

HEK293

内毒素水平

<1.0 EU/μg

生物活性

Pertuzumab (anti-HER2) (P412000) at 1.0 ug/mL can bind biotinylated Human ErbB2/HER2 Protein (rp169607), The EC50 for this effect is 25.99 ng/mL.

规格

库存

价格

数量

10μg

rp169607-10μg

现货

¥699.90

50μg

rp169607-50μg

现货

¥1,999.90

100μg

rp169607-100μg

现货

¥3,299.90

1mg

rp169607-1mg

期货

¥21,999.90

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概述规格储存与运输图片技术文档高级数据质检证书（CoA,COO,BSE/TSE 和分析图谱) 技术文档和文章溶液计算器

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为什么选择此级别

ActiBioPure™,His标签,PBS Only,无动物源,无叠氮钠,无载体,生物活性级提供 ≥90%(SDS-PAGE) 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。

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储存与运输

-20°C储存,避免反复冻融。超低温运输。请查阅批次 COA 获取详细规格。

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质量文档

SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。

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文献证明

在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。

概述

Purity:>90%, by SDS-PAGE visualized with Coomassie® Blue Staining.

Description：

ErbB2, also called Neu and Her2 (human epidermal growth factor receptor 2), is a type I membrane glycoprotein that is a member of the ErbB family of tyrosine kinase receptors. ErbB family members serve as receptors for the epidermal growth factor (EGF) family of growth factors. ErbB2 is widely expressed in epithelial cells and has also been found to be over-expressed in a large number of breast carcinomas. Among ErbB family members, ErbB2 is unique in that it has no identified ligands. Rather, ErbB2 heterodimerizes with the other members of the ErbB family (ErbB1 (EGFR), ErbB3, ErbB4) to form higher affinity signaling complexes. Because ErbB3 contains a defective kinase domain, the kinase domain of ErbB2 is responsible for initiating the tyrosine phosphorylation signal through the heterodimeric receptor. It has been found that a discrete three amino acid signal in the ErbB3 cytoplasmic domain is critical for transactivation of ErbB2. Interestingly, this same three amino acid signal has also been found in ErbB1 and ErbB4. Phosphoinositide 3-kinase has been shown to play a role in ErbB2 signal transduction. The cytoplasmic domain of ErbB2 has been shown to associate with beta-catenin and plakoglobin. Human ErbB2 consists of 1255 amino acids (aa) with a 21 aa signal sequence, a 631 aa extracellular domain, a 23 aa transmembrane region, and a 580 aa cytoplasmic domain. ErbB2 can be shed from the cell surface by proteolytic cleavage by an unidentified protease. ErbB2 appears to play roles in development, cancer, communication at the neuromuscular junction and regulation of cell growth and differentiation.

规格

产品名称

Recombinant Human ErbB2/HER2 Protein

别名

重组人ErbB2/HER2蛋白 | 重组酪氨酸激酶受体2蛋白 | 重组表皮生长因子受体2(ErbB2)蛋白 | 重组人 ErbB2/HER2 蛋白

英文别名

规格或纯度

无动物源,无载体,生物活性,ActiBioPure™,无叠氮钠,His标签,PBS Only,≥90%(SDS-PAGE)

生物活性

Pertuzumab (anti-HER2) (P412000) at 1.0 ug/mL can bind biotinylated Human ErbB2/HER2 Protein (rp169607), The EC50 for this effect is 25.99 ng/mL.

表达系统

HEK293

种属

人(Human)

氨基酸

1-652 aa

序列

MELAALCRWGLLLALLPPGAASTQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAEQRASPLTHHHHHH

纯度

>90% (SDS-PAGE)

蛋白标签

C-His

无载体

Yes

无动物源

Yes

来源

重组表达

预测分子量

70.2 kDa

SDS-PAGE

81.0-109.6 kDa, under reducing conditions

分子类型

蛋白质

产品线

biological_products

储存与运输

物理形态

冻干(Lyophilized)

储存缓冲液

Lyophilized from PBS, pH7.4

复溶

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute at 0.5 mg/mL in sterile distilled water. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.

储存条件

-20°C储存,避免反复冻融

运输条件

超低温运输

稳定性与储存

在 -20°C 下可保存 1 年。避免冷冻/解冻循环。

图片

Protein Bioactivity: Recombinant Human ErbB2/HER2 Protein (rp169607)

Recombinant Human ErbB2/HER2 Protein (rp169607) - Protein Bioactivity
Pertuzumab (anti-HER2) (P412000) at 1.0 ug/ml can bind biotinylated Human ErbB2/HER2 Protein (rp169607), The EC₅₀ for this effect is 25.99 ng/mL.

SDS-PAGE: Recombinant Human ErbB2/HER2 Protein (rp169607)

Recombinant Human ErbB2/HER2 Protein (rp169607) - SDS-PAGE
3 μg/lane of Recombinant Human ErbB2/HER2 Protein was resolved with SDS-PAGE under reducing (R) conditions and visualized by Coomassie® Blue staining, showing a band at 81.0-109.6 kDa under reducing conditions.

技术文档

📋 安全数据表 (SDS)

全面的危险、操作、储存及法规合规文件。

下载 SDS →

✅ 分析证书 (COA)

批次质量数据。输入批号以获取对应 COA。

查询 COA →

📊 产品数据表

产品规格和应用的快速参考摘要。

查看数据表 →

🔬 规格说明书

该级别的完整质量属性和验收标准。

查看规格说明 →

高级数据

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

输入批号以搜索分析图谱:

通过匹配包装上的批号来查找并下载产品的 COA，每批产品都进行了严格的验证，您可放心使用！

找到6个结果

批号(Lot Number)	证书类型	货号
ZJ24F0303504	分析证书	rp169607
ZJ24F0303505	分析证书	rp169607
ZJ24F0303506	分析证书	rp169607
ZJ25F0724547	分析证书	rp169607
ZJ25F0724548	分析证书	rp169607
ZJ25F0724549	分析证书	rp169607

技术文档和文章

阿拉丁®靶点蛋白

目录：技术文章

探索主题:

药物开发信号通路细胞因子靶点蛋白药物靶点受体免疫检查点细胞表面标记物

ErbB家族通路的结构特征、激活逻辑与信号输出

目录：技术文章

探索主题:

EGFR PI3K-AKT ErbB HER2 HER3 HER4 受体酪氨酸激酶 RAS-ERK 二聚化

Structural Features, Activation Logic, and Signaling Output of the ErbB Family Pathway

目录：技术文章

探索主题:

EGFR PI3K-AKT ErbB HER2 HER3 HER4 RAS-ERK Receptor tyrosine kinase Dimerization

Aladdin® Target Proteins

目录：技术文章

探索主题:

Cytokines Drug development Target Proteins Drug Targets Receptors Immune Checkpoints Cell Surface Markers Signaling Pathways

HER3信号网络在肿瘤进展、治疗耐药与靶向干预中的作用

目录：技术文章

探索主题:

抗体偶联药物 EGFR PI3K/AKT HER2 HER3 ERBB3 NRG1 异源二聚化治疗耐药双特异性抗体

Role of the HER3 Signaling Network in Tumor Progression, Therapeutic Resistance, and Targeted Intervention

目录：技术文章

探索主题:

EGFR PI3K/AKT HER2 HER3 ERBB3 NRG1 heterodimerization therapeutic resistance bispecific antibody antibody-drug conjugate

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Recombinant Human ErbB2/HER2 Protein

储存与运输

质量文档

文献证明

概述

规格

技术文档

📋 安全数据表 (SDS)

✅ 分析证书 (COA)

📊 产品数据表

🔬 规格说明书

高级数据

摩尔浓度计算器

稀释计算器

复溶计算器

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