ActiBioPure™,His标签,无动物源,无叠氮钠,无载体,生物活性 级 提供 ≥95%(SDS-PAGE) 纯度，适用于对基线干扰要求严格的色谱和分析工作流程。
-20°C储存,避免反复冻融。超低温运输 。请查阅批次 COA 获取详细规格。
SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。
在色谱分析、有机合成和交叉偶联反应领域已被 0 篇同行评审文献引用。
Purity
≥95% (SDS-PAGE)
Endotoxin level
＜0.1 EU/μg
Function
Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth.
Recombinant Human ErbB2/Her2 Protein (rp145688) - SDS-PAGE
2 μg/lane of Recombinant Human ErbB2/Her2 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing the band at 88 -108 kDa under reducing condition and 79 - 101 kDa under non-reducing condition.
Recombinant Human ErbB2/Her2 Protein (rp145688) - Protein Bioactivity
Immobilized Recombinant Human ErbB2/Her2 Protein (rp145688) at 1 μg/mL can bind Trastuzumab (anti-HER2) (T411999), the ED₅₀ for this effect is 1.4 ng/mL.
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| 批号(Lot Number) | 证书类型 | 货号 |
|---|---|---|
 ZJ25F0724653 |
分析证书 | rp145688 |
| ZJ25F0724654 |
分析证书 | rp145688 |
| ZJ25F0724655 |
分析证书 | rp145688 |
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