Immobilized Recombinant Human CEACAM7 Protein (rp188227) at 2.0 μg/mL can bind Recombinant Human CEACAM-1/CD66a Protein (rp144247) with the EC50 of 12.6 ng/mL.
Carcinoembryonic antigen-related cell adhesion molecule 7 (CEACAM-7), also known as CGM2, is an approximately 40 kDa GPI-anchored glycoprotein in the CEACAM family of adhesion molecules. Mature human CEACAM-7 consists of two Ig-like domains followed by the GPI anchor (2). Alternative splicing generates a short isoform that lacks the second Ig-like domain. CEACAM-7 is preferentially expressed on the luminal surface of epithelial cells near the mouth of colonic crypts and on pancreatic ductal epithelial cells. It is down-regulated during colorectal adenoma progression but can be up-regulated during the development of gastric carcinoma. R&D Systems in-house testing indicates that CEACAM-7 binds to CEACAM-1, consistent with the heterophilic interaction of CEACAM-1 with other CEACAM family members.
生物活性
Immobilized Recombinant Human CEACAM7 Protein (rp188227) at 2.0 μg/mL can bind Recombinant Human CEACAM-1/CD66a Protein (rp144247) with the EC50 of 12.6 ng/mL.
36.2-48.4 kDa, under reducing conditions; 34.8-47.8 kDa, under non-reducing conditions.
分子类型
蛋白质
产品线
生物产品
储存与运输
物理形态
冻干(Lyophilized)
储存缓冲液
Lyophilized from PBS, pH 7.4.
浓度
见COA
复溶
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute at 1.0 mg/mL in sterile distilled water. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
储存条件
-20°C储存,避免反复冻融
运输条件
超低温运输
稳定性与储存
-20℃保存1年;复溶后建议分装,避免反复冻融。
图片
Recombinant Human CEACAM7 Protein (rp188227) - Binding Activity Immobilized Recombinant Human CEACAM7 Protein (rp188227) at 2.0 μg/mL can bind Recombinant Human CEACAM-1/CD66a Protein (rp144247) with the EC50 of 12.6 ng/mL.
Recombinant Human CEACAM7 Protein (rp188227) - SDS-PAGE 3 μg/lane of Recombinant Human CEACAM7 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 36.2-48.4 kDa under reducing conditions and 34.8-47.8 kDa under non-reducing conditions.