Dipeptidyl aminopeptidase III | Dipeptidyl arylamidase III | dipeptidyl peptidase 3 | Dipeptidyl pep
规格或纯度
无载体,生物活性,ActiBioPure™,His标签,≥90%(SDS-PAGE),见COA
生化机理
Dipeptidyl peptidase 3 (DPP3) is a zinc-dependent peptidase distributed within the cytoplasm which cleaves dipeptides sequentially from the N-terminus of bioactive peptide substrates 4+ amino acid residues in length. DPP3 adopts a bi-lobed structure and features HEXXGH and EEXRAE/D motifs which coordinate the Zn2+ ion in its active site. DPP3’s gene is located on chromosome 11q12-13.113. DPP3 regulates the transformation of enkephalin, opioid peptide, terminal protein, and cell signaling. Deficiency results in ROS formation in the kidneys via elevated Angiotensin II (DPP3’s most prominent reported substrate), III, IV, and ANG (1-5). DPP3 is linked to the development of cardiovascular diseases through RAS, oxidative stress, and inflammation pathways. Depletion was associated with the upregulation of proapoptotic proteins SMAC and p53, making it a potential target in tumor therapy.
生物活性
Immobilized Recombinant Human DPP3 Protein (rp188309) at 1.0 μg/mL can bind Recombinant DPP3 Antibody (Ab100388) with the EC50 of 42.1 ng/mL.
Store at -20°C for 1 year. Avoid freeze/thaw cycle.
图片
Recombinant Human DPP3 Protein (rp188309) - ELISA Immobilized Recombinant Human DPP3 Protein (rp188309) at 1.0 μg/mL can bind Recombinant DPP3 Antibody (Ab100388) with the EC50 of 42.1 ng/mL.
Recombinant Human DPP3 Protein (rp188309) - SDS-PAGE 3 μg/lane of Recombinant Human DPP3 Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 74.7 kDa under reducing conditions and 74.7 kDa under non-reducing conditions.