Activator protein 1 | AP 1 | AP-1 | AP1 | cJun | Enhancer Binding Protein AP1 | JUN | Jun Activation Domain Binding Protein | Jun oncogene | JUN protein | Jun proto oncogene | JUN_HUMAN | JUNC | Oncogene JUN | p39 | Proto oncogene c jun | Proto oncogene c
规格或纯度
无载体,His标签,≥95%(SDS-PAGE),See COA
生化机理
Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells (PubMed:24623306). Binds to the USP28 promoter in colorectal cancer (CRC) cells (PubMed:24623306).
Post-translational: Ubiquitinated by the SCF(FBXW7), leading to its degradation (PubMed:14739463, PubMed:27458189).Ubiquitination takes place following phosphorylation, that promotes interaction with FBXW7 (PubMed:14739463). Phosphorylated by CaMK4 and PRKDC; phosphorylation enhances the transcriptional activity. Phosphorylated by HIPK3. Phosphorylated by DYRK2 at Ser-243; this primes the protein for subsequent phosphorylation by GSK3B at Thr-239. Phosphorylated at Thr-239, Ser-243 and Ser-249 by GSK3B; phosphorylation reduces its ability to bind DNA. Phosphorylated by PAK2 at Thr-2, Thr-8, Thr-89, Thr-93 and Thr-286 thereby promoting JUN-mediated cell proliferation and transformation. Phosphorylated by PLK3 following hypoxia or UV irradiation, leading to increase DNA-binding activity. Phosphorylated by VRK1 (PubMed:31527692). Acetylated at Lys-271 by EP300.
Store at -20°C for 1 year. Avoid freeze/thaw cycle.
图片
Recombinant Human c-Jun Protein (rp214406) - SDS-PAGE 3 μg/lane of Recombinant Human c-Jun Protein was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie® Blue staining, showing a band at 39.6 & 81.7 kDa under reducing conditions and 33.9-40.0 & 82.4 kDa under non-reducing conditions. c-Jun forms homodimers through leucine zippers. In addition, phosphorylation modification leads to conformational changes in it (PMID: 8383624).
ZJ25F0320008
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