ATP-γ-S,激酶底物

货号 (SKU)	包装规格	是否现货
A274887-1mg	1mg	现货
A274887-5mg	5mg	现货
A274887-25mg	25mg	现货

基本描述

别名	腺苷5′-[γ-硫代]三磷酸盐四锂盐 \| 腺苷5′-（3-硫代三磷酸盐）四锂盐
英文别名	Adenosine 5'-(γ-thio)-triphosphate (lithium salt) \| P'-anhydride with phosphorothioic acid adenosine 5'-(trihydrogen diphosphate), tetralithium salt \| Adenosine 5′-[γ-thio]triphosphate tetralithium salt \| ATP-γ-S \| Ado-5′-PPP[S]
规格或纯度	≥80%
英文名称	ATP-gamma-S
生化机理	腺苷5′-[γ-硫代]三磷酸(ATP-γ-S)是一种广泛使用的非水解ATP类似物，用于研究包括细胞外功能等多种过程中ATP结合ATP位点的影响。ATP- γ-S是一种P2嘌呤能激动剂，能够增强Ca2+-活化 K+通道活性。 ATP- γ-S能够在激酶反应中取代ATP，生成硫代磷酸化蛋白，耐受蛋白磷酸酶，调节泛素偶联物和26S蛋白酶体结合的ATP依赖性步骤。 ATP-γ -S可差分调节Toll样受体4介导的细胞存活和死亡。
储存温度	-20°C储存,干燥
运输条件	超低温冰袋运输
备注	本产品以一种（或多种）包装尺寸提供，并进行冷冻干燥。因此，内含物可能会覆盖小瓶的底部或壁，因此可能不容易看到。请参阅我们的常见问题解答和信息页面以获取有关处理的更多详细信息。不稳定重新制作解决方案并立即使用。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。
产品介绍	腺苷5′-[γ-硫代]三磷酸腺苷四锂盐已用于处理花粉粒，测定三磷酸腺苷（ATP）或其水解产物的抑制作用。它还用于筛选硫代磷酸酯靶蛋白。 Adenosine 5′-[γ-thio]triphosphate tetralithium salt has been used to treat the pollen grains to determine the inhibitory effect of adenosine triphosphate (ATP) or its hydrolysis product. It has also been used to select thiophosphorylate target protein.

名称和标识符

IUPAC Name	tetralithium;[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl] dioxidophosphinothioyl phosphate
INCHI	InChI=1S/C10H16N5O12P3S.4Li/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(25-10)1-24-28(18,19)26-29(20,21)27-30(22,23)31;;;;/h2-4,6-7,10,16-17H,1H2,(H,18,19)(H,20,21)(H2,11,12,13)(H2,22,23,31);;;;/q;4*+1/p-4/t4-,6-,7-,10-;;;;/m1..../s1
InChi Key	DWQFDOIBOYDYKH-KWIZKVQNSA-J
Canonical SMILES	[Li+].[Li+].[Li+].[Li+].C1=NC(=C2C(=N1)N(C=N2)C3C(C(C(O3)COP(=O)([O-])OP(=O)([O-])OP(=S)([O-])[O-])O)O)N
Isomeric SMILES	[Li+].[Li+].[Li+].[Li+].C1=NC(=C2C(=N1)N(C=N2)[C@H]3[C@@H]([C@@H]([C@H](O3)COP(=O)([O-])OP(=O)([O-])OP(=S)([O-])[O-])O)O)N
PubChem CID	5311341
分子量	546.98

化学和物理性质

溶解性	H2O: 25 mg/mL
敏感性	对湿度敏感

安全和危险性（GHS）

象形图	Harmful
信号词	Warning
危险声明	H315: Causes skin irritation H319: Causes serious eye irritation H335: May cause respiratory irritation
预防措施声明	P261,P305+P351+P338,P280,P302+P352,P321,P405,P501,P264,P271,P304+P340,P403+P233,P362+P364,P264+P265,P337+P317,P332+P317,P319

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参考文献

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ATP-γ-S,激酶底物

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基本描述

名称和标识符

化学和物理性质

安全和危险性（GHS）

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