Otelixizumab (anti-CD3)

功能和特点

规格或纯度: Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
应用: ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR)
反应种属:
亚型: Human IgG1

有货

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货号 (SKU)	包装规格	是否现货
Ab170522-100μg	100μg	期货
Ab170522-1mg	1mg	现货
Ab170522-5mg	5mg	现货
Ab170522-10mg	10mg	期货

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基本信息

产品名称	Otelixizumab (anti-CD3)
别名	奥昔组单抗
英文别名	Anti-CD3 Reference Antibody (otelixizumab) \| Otelixizumab \| ChAglyCD3 \| TRX 4 \| 4930549J05Rik antibody \| A430104F18Rik antibody \| AW552088 antibody \| Cd247 antibody \| CD247 antigen antibody \| CD247 antigen, zeta subunit antibody \| CD247 molecule antibody
规格或纯度	Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
特异性	CD3D
应用	ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR)

产品属性

抗体类型	Primary antibody
克隆	1
Format	Whole IgG
亚型	Human IgG1
轻链亚型	LambdaC2
SDS-PAGE	27.0 kDa (Light Chain) & 51.5 kDa (Heavy Chain), under reducing conditions; 181.4 kDa, under non-reducing conditions.
纯化方法	Protein A purified
纯度	>95%
来源	CHO supernatant
物理外观	Liquid
储存缓冲液	Supplied as a 0.22 μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂	No
浓度	Lot by Lot
储存温度	-80℃储存,避免反复冻融
运输条件	超低温冰袋运输
稳定性与储存	Store at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle.
CAS编号和信息	881191-44-2

数据库链接

IMGT/mAb-DB	235
Wikipedia	Otelixizumab

图片

Flow Cytometry: Otelixizumab (anti-CD3) (Ab170522)

Otelixizumab (anti-CD3) (Ab170522) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling CD3 with Otelixizumab (anti-CD3) (Ab170522) conjugated with biotin (right panel) compared with Human IgG (Ab170213) conjugated with biotin - Isotype Control (left panel) and detected with SA-PE (rp156250).

Flow Cytometry: Otelixizumab (anti-CD3) (Ab170522)

Otelixizumab (anti-CD3) (Ab170522) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood lymphocytes labelling CD3 (red) with Otelixizumab (anti-CD3) (Ab170522) conjugated with biotin and detected with SA-PE (rp156250). Blue - Isotype control, human IgG (Ab170213) conjugated with biotin. Black - Unlabelled control, cells without incubation with primary antibody.

Flow Cytometry: Otelixizumab (anti-CD3) (Ab170522)

Otelixizumab (anti-CD3) (Ab170522) - Flow Cytometry
Flow Cytometry analysis of Jurkat cells labelling CD3 (red) with Otelixizumab (anti-CD3) (Ab170522). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

SEC: Otelixizumab (anti-CD3) (Ab170522)

Otelixizumab (anti-CD3) (Ab170522) - SEC
The purity of Otelixizumab (anti-CD3) (Ab170522) is more than 95% verified by HPLC.

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参考文献

1. Keymeulen B, Vandemeulebroucke E, Ziegler AG, Mathieu C, Kaufman L, Hale G, Gorus F, Goldman M, Walter M, Candon S et al.. (2005) Insulin needs after CD3-antibody therapy in new-onset type 1 diabetes.. N Engl J Med, 352 (25): (2598-608). [PMID:15972866]
2. Chatenoud L, Bluestone JA. (2007) CD3-specific antibodies: a portal to the treatment of autoimmunity.. Nat Rev Immunol, 7 (8): (622-32). [PMID:17641665]
3. Kaufman A, Herold KC. (2009) Anti-CD3 mAbs for treatment of type 1 diabetes.. Diabetes Metab Res Rev, 25 (4): (302-6). [PMID:19319985]
4. Sherry N, Hagopian W, Ludvigsson J, Jain SM, Wahlen J, Ferry Jr RJ, Bode B, Aronoff S, Holland C, Carlin D et al.. (2011) Teplizumab for treatment of type 1 diabetes (Protégé study): 1-year results from a randomised, placebo-controlled trial.. Lancet, 378 (9790): (487-97). [PMID:21719095]
5. Bolt S, Routledge E, Lloyd I, Chatenoud L, Pope H, Gorman SD, Clark M, Waldmann H. (1993) The generation of a humanized, non-mitogenic CD3 monoclonal antibody which retains in vitro immunosuppressive properties.. Eur J Immunol, 23 (2): (403-11). [PMID:8436176]
6. de Saint Basile G, Geissmann F, Flori E, Uring-Lambert B, Soudais C, Cavazzana-Calvo M, Durandy A, Jabado N, Fischer A, Le Deist F. (2004) Severe combined immunodeficiency caused by deficiency in either the delta or the epsilon subunit of CD3.. J Clin Invest, 114 (10): (1512-7). [PMID:15546002]
7. Phillips, J H JH and 5 more authors.. (1992) Ontogeny of human natural killer (NK) cells: fetal NK cells mediate cytolytic function and express cytoplasmic CD3 epsilon,delta proteins.. The Journal of experimental medicine, (1): (). [PMID:1372642]
8. Barber, E K EK, Dasgupta, J D JD, Schlossman, S F SF, Trevillyan, J M JM and Rudd, C E CE.. (1989) The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex.. Proceedings of the National Academy of Sciences of the United States of America, (): (). [PMID:2470098]
9. Alexander, D D and 5 more authors.. (1989) Dephosphorylation of the human T lymphocyte CD3 antigen.. European journal of biochemistry, (15): (). [PMID:2540970]
10. van den Elsen, P P, Georgopoulos, K K, Shepley, B A BA, Orkin, S S and Terhorst, C C.. (1986) Exon/intron organization of the genes coding for the delta chains of the human and murine T-cell receptor/T3 complex.. Proceedings of the National Academy of Sciences of the United States of America, (): (). [PMID:2939461]
11. Tunnacliffe, A A, Sims, J E JE and Rabbitts, T H TH.. (1986) T3 delta pre-mRNA is transcribed from a non-TATA promoter and is alternatively spliced in human T cells.. The EMBO journal, (): (). [PMID:3488209]
12. van den Elsen, P P and 6 more authors.. (1984) Isolation of cDNA clones encoding the 20K T3 glycoprotein of human T-cell receptor complex.. Nature, (): (). [PMID:6095101]
13. Wilde, M I MI and Goa, K L KL.. (1996) Muromonab CD3: a reappraisal of its pharmacology and use as prophylaxis of solid organ transplant rejection.. Drugs, (): (). [PMID:8861551]
14. Doucey, Marie-Agnès MA and 7 more authors.. (2003) CD3 delta establishes a functional link between the T cell receptor and CD8.. The Journal of biological chemistry, (31): (). [PMID:12215456]
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16. Dadi, Harjit K HK, Simon, Amos J AJ and Roifman, Chaim M CM.. (2003) Effect of CD3delta deficiency on maturation of alpha/beta and gamma/delta T-cell lineages in severe combined immunodeficiency.. The New England journal of medicine, (6): (). [PMID:14602880]
17. Jin, Pei P and 7 more authors.. (2004) PCR isolation and cloning of novel splice variant mRNAs from known drug target genes.. Genomics, (): (). [PMID:15028279]
18. Brill, Laurence M LM and 5 more authors.. (2004) Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.. Analytical chemistry, (15): (). [PMID:15144186]
19. Arnett, Kelly L KL, Harrison, Stephen C SC and Wiley, Don C DC.. (2004) Crystal structure of a human CD3-epsilon/delta dimer in complex with a UCHT1 single-chain antibody fragment.. Proceedings of the National Academy of Sciences of the United States of America, (16): (). [PMID:15534202]
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Otelixizumab (anti-CD3)

库存信息

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库存信息

基本信息

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数据库链接

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