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Mavrilimumab (anti-CD116)

功能和特点
  • 规格或纯度: Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG4SP; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
  • 应用: ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR)
  • 反应种属:
  • 亚型: Human IgG4SP
有货

库存信息

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库存信息

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库存信息

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库存信息

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货号 (SKU) 包装规格 是否现货 价格 数量
Ab170528-100μg
100μg 期货 Stock Image
Ab170528-1mg
1mg 现货 Stock Image
Ab170528-5mg
5mg 现货 Stock Image
Ab170528-10mg
10mg 期货 Stock Image

基本信息

产品名称 Mavrilimumab (anti-CD116)
别名 玛弗利木单抗
英文别名 CD116 antigen | CD116 | CDw116 | colony stimulating factor 2 receptor alpha subunit | colony stimulating factor 2 receptor, alpha, low-affinity(granulocyte-macrophage) | CSF2R | CSF2RA | CSF2RAX | CSF2RAY | CSF2RX | CSF2RY | GM-CSF R alpha | GM-CSF recept
规格或纯度 Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG4SP; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated
特异性 CD116
应用 ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR)
偶联标记 1

产品属性

抗体类型 Primary antibody
克隆 1
Format Whole IgG
亚型 Human IgG4SP
轻链亚型 LambdaC2
SDS-PAGE 28.7 kDa (Light Chain) & 52.9 kDa (Heavy Chain), under reducing conditions; 165.8 kDa, under non-reducing conditions.
纯化方法 Protein A purified
纯度 >95%
来源 CHO supernatant
物理外观 Liquid
储存缓冲液 Supplied as a 0.22 μm filtered solution in 100mM Pro-Ac, 20mM Arg, pH 5.0
防腐剂 No
浓度 Lot by Lot
储存温度 -80℃储存,避免反复冻融
运输条件 超低温冰袋运输
稳定性与储存 Store at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle.
CAS编号和信息 1085337-57-0

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图片

Mavrilimumab (anti-CD116) (Ab170528) - Flow Cytometry
Flow Cytometry analysis of U937 cells labelling CD116 (red) with Mavrilimumab (anti-CD116) (Ab170528). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG4SP. Black - Unlabelled control, cells without incubation with primary antibody.

Mavrilimumab (anti-CD116) (Ab170528) - SEC
The purity of Mavrilimumab (anti-CD116) (Ab170528) is more than 95% verified by HPLC.

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参考文献

1. Nair JR, Edwards SW, Moots RJ.  (2012)  Mavrilimumab, a human monoclonal GM-CSF receptor-α antibody for the management of rheumatoid arthritis: a novel approach to therapy..  Expert Opin Biol Ther,  12  (12):  (1661-8).  [PMID:23094973]
2. Burmester GR, McInnes IB, Kremer JM, Miranda P, Vencovský J, Godwood A, Albulescu M, Michaels MA, Guo X, Close D et al..  (2018)  Mavrilimumab, a Fully Human Granulocyte-Macrophage Colony-Stimulating Factor Receptor α Monoclonal Antibody: Long-Term Safety and Efficacy in Patients With Rheumatoid Arthritis..  Arthritis Rheumatol,  70  (5):  (679-689).  [PMID:29361199]
3. Rappold, G G, Willson, T A TA, Henke, A A and Gough, N M NM..  (1992)  Arrangement and localization of the human GM-CSF receptor alpha chain gene CSF2RA within the X-Y pseudoautosomal region..  Genomics,    ():  ().  [PMID:1358805]
4. Crosier, K E KE, Wong, G G GG, Mathey-Prevot, B B, Nathan, D G DG and Sieff, C A CA..  (1991)  A functional isoform of the human granulocyte/macrophage colony-stimulating factor receptor has an unusual cytoplasmic domain..  Proceedings of the National Academy of Sciences of the United States of America,    (1):  ().  [PMID:1715577]
5. Raines, M A MA and 5 more authors..  (1991)  Identification and molecular cloning of a soluble human granulocyte-macrophage colony-stimulating factor receptor..  Proceedings of the National Academy of Sciences of the United States of America,    (15):  ().  [PMID:1832774]
6. Ashworth, A A and Kraft, A A..  (1990)  Cloning of a potentially soluble receptor for human GM-CSF..  Nucleic acids research,    (11):  ().  [PMID:2148207]
7. Gearing, D P DP, King, J A JA, Gough, N M NM and Nicola, N A NA..  (1989)  Expression cloning of a receptor for human granulocyte-macrophage colony-stimulating factor..  The EMBO journal,    (1):  ().  [PMID:2555171]
8. Hu, X X, Emanuel, P D PD and Zuckerman, K S KS..  (1994)  Cloning and sequencing of the cDNAs encoding two alternative splicing-derived variants of the alpha subunit of the granulocyte-macrophage colony-stimulating factor receptor..  Biochimica et biophysica acta,    (8):  ().  [PMID:8086503]
9. Nakagawa, Y Y, Kosugi, H H, Miyajima, A A, Arai, K K and Yokota, T T..  (1994)  Structure of the gene encoding the alpha subunit of the human granulocyte-macrophage colony stimulating factor receptor. Implications for the evolution of the cytokine receptor superfamily..  The Journal of biological chemistry,    (8):  ().  [PMID:8144676]
10. Ross, Mark T MT and 281 more authors..  (2005)  The DNA sequence of the human X chromosome..  Nature,    (17):  ().  [PMID:15772651]
11. Xiao, Rong R and 5 more authors..  (2006)  [Expression of soluble GM-CSF-Ralpha in patients with acute myeloid leukemia]..  Zhongguo shi yan xue ye xue za zhi,    ():  ().  [PMID:16638185]
12. Chen, Jian J, Cárcamo, Juan M JM and Golde, David W DW..  (2006)  The alpha subunit of the granulocyte-macrophage colony-stimulating factor receptor interacts with c-Kit and inhibits c-Kit signaling..  The Journal of biological chemistry,    (4):  ().  [PMID:16760463]
13. Wang, Ying Y and 8 more authors..  (2007)  Adaptive secretion of granulocyte-macrophage colony-stimulating factor (GM-CSF) mediates imatinib and nilotinib resistance in BCR/ABL+ progenitors via JAK-2/STAT-5 pathway activation..  Blood,    (1):  ().  [PMID:17090651]
14. Lencz, T T and 7 more authors..  (2007)  Converging evidence for a pseudoautosomal cytokine receptor gene locus in schizophrenia..  Molecular psychiatry,    ():  ().  [PMID:17522711]
15. Pelley, Jennifer L JL, Nicholls, Chris D CD, Beattie, Tara L TL and Brown, Christopher B CB..  (2007)  Discovery and characterization of a novel splice variant of the GM-CSF receptor alpha subunit..  Experimental hematology,    ():  ().  [PMID:17681666]
16. Hansen, Guido G and 12 more authors..  (2008)  The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation..  Cell,    (8):  ().  [PMID:18692472]
17. Martinez-Moczygemba, Margarita M and 12 more authors..  (2008)  Pulmonary alveolar proteinosis caused by deletion of the GM-CSFRalpha gene in the X chromosome pseudoautosomal region 1..  The Journal of experimental medicine,    (24):  ().  [PMID:18955567]
18. Suzuki, Takuji T and 14 more authors..  (2008)  Familial pulmonary alveolar proteinosis caused by mutations in CSF2RA..  The Journal of experimental medicine,    (24):  ().  [PMID:18955570]
19. Han, Xuesheng X and Parker, Tory L TL..  (2017)  Anti-inflammatory activity of clove (Eugenia caryophyllata) essential oil in human dermal fibroblasts..  Pharmaceutical biology,    ():  ().  [PMID:28407719]
20. Chen, X X, Ji, Z L ZL and Chen, Y Z YZ..  (2002)  TTD: Therapeutic Target Database..  Nucleic acids research,    (1):  ().  [PMID:11752352]