Name: 链脲佐菌素, DNA 抑制剂
SKU: S408311
Availability: InStock

链脲佐菌素, DNA 抑制剂

CAS: 18883-66-4 货号: S408311 分子式: C₈H₁₅N₃O₇ 分子量: 265.22 Beilstein号: 2060675 EC号: 242-646-8

概述规格名称和识别符技术文档高级数据质检证书（CoA,COO,BSE/TSE 和分析图谱) 化学和物理性质安全和危险性（GHS）此产品的引用文献技术文档和文章溶液计算器

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为什么选择此级别

，适用于对基线干扰要求严格的色谱和分析工作流程。

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储存与运输

-80℃储存。特低温运输。请查阅批次 COA 获取详细规格。

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质量文档

SDS、COA、产品数据表及规格说明书均可下载。可通过批号查询获取批次 COA。

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文献证明

在色谱分析、有机合成和交叉偶联反应领域已被 208 篇同行评审文献引用。

概述

Information

Streptozotocin (STZ, NSC-85998, Streptozocin, U 9889) is a glucosamine-nitrosourea derivative, which is a DNA-methylating , carcinogenic, antibiotic and diabetes inducing agent. Streptozotocin induces autophagy and apoptosis . Solutions are best fresh-pre
In vitro

Streptozotocin directly methylates DNA and is highly genotoxic, producing DNA strand breaks, alkali-labile sites, unscheduled DNA synthesis, DNA adducts, chromosomal aberrations, micronuclei, sister chromatid exchanges, and cell death. Free radicals are involved in the production of DNA and chromosome damage by Streptozotocin. Streptozotocin is toxic to pancreatic beta cell. Exposed to 15 mM Streptozotocin for 1 hr followed by a 24 hrs recovery period induces apoptosis in murine pancreatic beta cell line, INS-1. Streptozotocin (30 mM) causes the cells to undergo necrosis (22%) as well as apoptosis (17%).

In vivo

Streptozotocin is often used to induce diabetes mellitus in experimental animals. Streptozotocin is selectively accumulated in pancreatic beta cells via the low-affinity GLUT 2 glucose transporter. Streptozotocin (60 mg/kg) injection for 4 month induces rapid degranulation of beta cells without necrosis, development of cataracts and accumulation of glycogen in the proximal convoluted tubules of the kidney. Streptozotocin (100 mg/kg) produces lesions in the exocrine cells of the pancreas, and persistence of small, possibly secretory, granules in the Golgi zone of beta cells in rats of ‘Streptozotocin diabetes’. Streptozotocin is found to be carcinogenic in rats, mice and hamster. A single administration of Streptozotocin is able to induce tumors in kidney, liver, lung, pancreas, uterine and liver tumors in hamster. Intraperitoneally injected with Streptozotocin (100-150 mg/kg) for normotensive Wistar Kyoto rats (WKY) for 12 months induces carcinogenesis with tumors incidence of 70% in liver, 20% in kidney and 10% in liver and kidney.
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

规格

英文别名

NSC-85998, Streptozocin, U 9889 | 1-methyl-1-nitroso-3-((2S,3R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)-tetrahydro-2H-pyran-3-yl)urea

规格或纯度

10mM in DMSO

英文名称

Streptozotocin (STZ)

生化机理

链脲佐菌素（STZ，NSC-85998，Streptozocin，U 9889）是一种氨基葡萄糖-亚硝脲衍生物，具有 DNA 甲基化、致癌、抗生素和糖尿病诱导作用。链脲佐菌素可诱导自噬和细胞凋亡。溶液最好新鲜配制。

储存条件

-80℃储存

运输条件

特低温运输

作用类型

抑制剂

作用机制

DNA 抑制剂

名称和识别符

EC号

242-646-8

分子类型

小分子

Isomeric SMILES

CN(C(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@@H]1O)CO)O)O)N=O

UN Number

3077

Packing Group

III

分子量

265.22

Beilstein号

2060675

技术文档

📋 安全数据表 (SDS)

全面的危险、操作、储存及法规合规文件。

下载 SDS →

✅ 分析证书 (COA)

批次质量数据。输入批号以获取对应 COA。

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📊 产品数据表

产品规格和应用的快速参考摘要。

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🔬 规格说明书

该级别的完整质量属性和验收标准。

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高级数据

化学和物理性质

熔点

115°C

安全和危险性（GHS）

WGK Germany

RTECS

LZ5775000

Class

个人防护装备

Eyeshields,full-face particle respirator type N100 (US),Gloves,respirator cartridge type N100 (US),type P1 (EN143) respirator filter,type P3 (EN 143) respirator cartridges

质检证书（CoA,COO,BSE/TSE 和分析图谱)

C of A & Other Certificates(BSE/TSE, COO):

输入批号以搜索分析图谱:

技术文档和文章

引领生物医学变革的技术——动物造模

目录：技术文章

探索主题:

疾病模型实验动物动物造模技术动物模型生物医学研究基因编辑药物研发精准医学

The Technology Driving Biomedical Revolution — Animal Modeling

目录：技术文章

探索主题:

Drug development Disease Models Animal Modeling Technology Animal Models Biomedical Research Experimental Animals Gene Editing Precision Medicine

代谢性疾病动物模型构建技术详解

目录：技术文章

探索主题:

动物造模链脲佐菌素(STZ) 糖尿病代谢性疾病 NAFLD模型动物模型构建遗传性模型诱导性模型学毒理学模型糖尿病模型

A Detailed Guide to the Construction of Animal Models for Metabolic Diseases

目录：技术文章

探索主题:

Animal Modeling Genetic Models Streptozotocin (STZ) diabetes mellitus metabolic diseases NAFLD model animal model construction induced models chemical toxicology models diabetes models

常见动物疾病模型的建立及其实验方法

目录：技术文章

探索主题:

高血压造模结直肠癌（CAC）造模肝肿瘤造模急性肾损伤（AKI）造模帕金森病造模阿尔兹海默症造模糖尿病造模高脂血症造模高尿酸血症造模免疫/炎症造模诱导性基因调控模型

Establishment of Common Animal Disease Models and Their Experimental Methods

目录：技术文章

探索主题:

Hypertension Modeling Colitis-Associated Colorectal Cancer (Cac) Modeling Liver Tumor Modeling Acute Kidney Injury (Aki) Modeling Parkinson’S Disease Modeling Alzheimer’S Disease Modeling Diabetes Modeling Hyperlipidemia Modeling Hyperuricemia Modeling Immune/Inflammation Modeling Inducible Gene Regulation Models

糖尿病动物模型建立与评价方法

目录：技术文章

探索主题:

糖尿病动物造模 STZ诱导模型四氧嘧啶模型高脂饮食模型 HFD+STZ模型 NOD小鼠 db/db小鼠 ZDF大鼠

Establishment and Evaluation Methods of Diabetic Animal Models

目录：技术文章

探索主题:

diabetic animal modeling STZ-induced model alloxan model high-fat diet model HFD+STZ model NOD mice db/db mice ZDF rats

Endocrinology/Hormones（内分泌与激素）在代谢调控、生殖功能与疾病研究中的应用

目录：技术文章

探索主题:

Hormones 胰岛素 HPA轴 GPCR 内分泌激素 Endocrinology 甲状腺激素类固醇激素性激素

Applications of Endocrinology/Hormones in Metabolic Regulation, Reproductive Function, and Disease Research

目录：技术文章

探索主题:

Hormones Insulin HPA axis GPCR Endocrinology thyroid hormone steroid hormone sex hormone

天然产物抗糖尿病作用机制、代表性活性成分与研究应用

目录：技术文章

探索主题:

天然产物糖尿病氧化应激胰岛素抵抗药物筛选胰岛β细胞肠道菌群肝糖异生葡萄糖摄取

Antidiabetic Mechanisms, Representative Bioactive Compounds, and Research Applications of Natural Products

目录：技术文章

探索主题:

Natural products diabetes mellitus Oxidative Stress Insulin Resistance gut microbiota drug screening Pancreatic β cells Hepatic Gluconeogenesis Glucose Uptake

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