Rabbit anti Human ANGPT2 Antibody, Polyclonal antibody, could be used for WB, IHC and so on.
Application
WB: 0.2-2µg/mL
IHC: 5-20µg/mL
IF/ICC: 5µg/mL
Protein Function
Can induce tyrosine phosphorylation of TIE2. Binds to TIE2 receptor and counteracts blood vessel maturation/stability mediated by angiopoietin-1. Its function may be context-dependent. In the absence of angiogenic inducers, such as VEGF, ANG2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.