Mouse anti Human CD11b Antibody, Monoclonal (ICRF44), could be used for Flow, WB, IHC, IP and so on.
Application
Flow: ≤ 1.0µg/100w cells
WB: Use at an assay dependent concentration.
IP: Use at an assay dependent concentration.
IHC: Use at an assay dependent concentration.
Protein Function
Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.