Non-receptor tyrosine kinase involved in various processes such as cell cycle progression, apoptosis, mitotic recombination, genetic instability and histone modifications. In the cytoplasm, plays a pivotal role in signal transduction via its association with cytokine receptors, which constitutes an initiating step in signaling for many members of the cytokine receptor superfamily including the receptors for growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), granulocyte-macrophage colony-stimulating factor (CSF2), thrombopoietin (THPO) and multiple interleukins. Following stimulation with erythropoietin (EPO) during erythropoiesis, it is autophosphorylated and activated, leading to its association with erythropoietin receptor (EPOR) and tyrosine phosphorylation of residues in the EPOR cytoplasmic domain. Also involved in promoting the localization of EPOR to the plasma membrane. Also acts downstream of some G-protein coupled receptors. Plays a role in the control of body weight (By similarity). Mediates angiotensin-2-induced ARHGEF1 phosphorylation. In the nucleus, plays a key role in chromatin by specifically mediating phosphorylation of 'Tyr-41' of histone H3 (H3Y41ph), a specific tag that promotes exclusion of CBX5 (HP1 alpha) from chromatin.
宿主种属
兔(Rabbit)
特异性
JAK2
种属反应性
人(Human),大鼠(Rat),小鼠(Mouse)
预测反应种属
苏门答腊猩猩(Sumatran orangutan)
免疫原
A synthetic peptide derived from human JAK2 (AA 1100-1132)
阳性对照
WB: NIH/3T3 and C6 cell lysates. IF/ICC: HeLa, Jurkat cells.
Recombinant JAK2 Antibody (Ab111455) - Western Blot All lanes: Recombinant JAK2 Antibody (Ab111455) at 1/2000 dilution Samples: Lysates at 20 µg per lane Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/20000 dilution
Predicted band size: 131 kDa Observed band size: 122 kDa Exposure time: 33.4 s
Recombinant JAK2 Antibody (Ab111455) - IF/ICC Immunofluorescent analysis of JAK2 in HeLa cells, using the Recombinant JAK2 Antibody (Ab111455) at 1/50 dilution.
Recombinant JAK2 Antibody (Ab111455) - IF/ICC Immunofluorescent analysis of Jurkat cells, using Recombinant JAK2 Antibody (Ab111455).
ZJ25F1129941
危险品化学品经营许可证（带存储）