Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CCN2. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CCN2. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion.
宿主种属
兔(Rabbit)
特异性
MMP13
种属反应性
人(Human),小鼠(Mouse)
免疫原
A synthetic peptide derived from human MMP13 (AA 400-471).
Recombinant MMP13 Antibody (Ab115637) - Western Blot All lanes: Recombinant MMP13 Antibody (Ab115637) at 1/1000 dilution Samples: Lysates at 20 µg per lane Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/40000 dilution Predicted band size: 54 kDa Observed band size: 61 kDa Exposure time: 5.1 s
ZJ24F1215855
危险品化学品经营许可证（带存储）