Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis.
宿主种属
兔(Rabbit)
特异性
p53
种属反应性
人(Human)
免疫原
A synthetic peptide derived from human p53 (AA 1-30).
阳性对照
WB: A431 and HEK293 cell lysates. IHC: Human colon cancer tissue. IF/ICC: HeLa cells.
Store at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.
图片
Recombinant p53 Antibody (Ab119828) - Western Blot All lanes: Recombinant p53 Antibody (Ab119828) at 1/2000 dilution Samples: Lysates at 20 µg per lane Secondary: Goat Anti-Rabbit IgG H&L (HRP) (Ab170144) at 1/10000 dilution
Predicted band size: 44 kDa Observed band size: 51 kDa Exposure time: 29.1 s
Recombinant p53 Antibody (Ab119828) - IF/ICC Immunofluorescent analysis of HeLa cells, using Recombinant p53 Antibody (Ab119828).
Recombinant p53 Antibody (Ab119828) - IHC Immunohistochemical analysis of paraffin-embedded human colon cancer, using Recombinant p53 Antibody (Ab119828).
ZJ25F0622239
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