Mouse anti Human p53 Antibody, Recombinant (MyM1-p53), could be used for IHC and so on. Application IHC: 1/100-1/200 Protein Function Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis.
Recombinant p53 Antibody (Ab119824) - IHC Immunohistochemistry analysis of paraffin-embedded human lung adenocarcinoma tissue labelling p53 with Recombinant p53 Antibody (Ab119824) at 1/200 dilution. The section was incubated with Ab119824 for 30 mins at room temperature. Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 was used for antigen retrieval.
ZJ24F0505290
危险品化学品经营许可证（带存储）